PROFLAKTİK SALPİNGO-OOFOREKTOMİ YAPILAN AİLEVİ MEME VE OVER KANSER SENDROMLU HASTALARDA KLİNİK BULGULAR FARKLI MIDIR ?

AMAÇ: Bu çalışmanın amacı; BRCA1/2 (breast cancer1/2) gen mutasyonu nedeniyle proflaktik cerrahi (bilateral salpingo-ooforektomi; BSO) yapılan kadınlarda demografik ve tıbbi özelliklerin BRCA1 ve BRCA2 gen mutasyonu taşıyıcıları arasında karşılaştırılmasıdır.GEREÇ VE YÖNTEM: Kliniğimizde son 5 yıl içerisinde BRCA1/2 gen mutasyonu saptanmış ve proflaktik cerrahi (BSO) yapılmış olan 24 kadın çalışmaya alındı. BRCA1 ve BRCA2 gen mutasyonu saptanan hastalar yaş, gebelik ve doğum sayısı, vücut kitle indeksi (VKİ), Ca125 değeri, infertilite ve meme kanseri öyküsü, cerrahi şekli ve postop patoloji sonuçları açısından karşılaştırıldı.BULGULAR: Çalışmaya alınan hastaların yaş ortalaması 45,5±5,8, VKİ 27,6±5,4kg/m2, Ca125 değeri 17,9±14,1İÜ/ml saptanmış olup hastaların %79,2’sinde meme kanseri öyküsü mevcuttu. Hastaların %62,5’inde BRCA1 ve %37,5’inde BRCA2 gen mutasyonu mevcuttu. BRCA1 ve BRCA2 grupları arasında yapılan karşılaştırmada yaş, gebelik ve doğum sayısı, VKİ, Ca125 değeri, infertilite ve meme kanseri öyküsü, cerrahi şekli ve postoperatif patoloji sonuçları açısından her iki grup arasında istatistiksel olarak anlamlı fark saptanmadı (p>0,05). Postoperatif patolojik değerlendirme neticesinde bir hastada over kanseri (BRCA1 grubunda) saptandı.SONUÇ: BRCA1 ve BRCA2 gen mutasyonu olan hastalarda demografik ve tıbbi özellikler açısından fark bulunmayıp, nihai patoloji sonucunda malignite çıkabileceği akılda tutulmalıdır.

Anahtar Kelimeler:

BRCA1, BRCA2, Over, Kanser, Proflaksi, Cancer, Prophylaxis

ARE THE CLINICAL FINDINGS DIFFERENT IN PATIENTS WITH FAMILIAL BREAST AND OVARIAN CANCER SYNDROME WHO UNDERWENT PROPHYLACTIC SALPINGO-OOPHORECTOMY ?

OBJECTIVE: The aim of this study was comparison of demographic and medical characteristics among BRCA1 and BRCA2 gene mutation carriers in women who underwent prophylactic surgery (bilateral salpingo-oophorectomy; BSO)due to BRCA1/2 (breast cancer1/2) gene mutation.MATERIAL AND METHODS: Twenty-four women who were found to have BRCA1/2 gene mutations in our clinic in the last 5 years and had undergone prophylactic surgery (BSO) were included in the study. Patients with BRCA1 and BRCA2 gene mutations were compared in terms of age, number of pregnancies and births, body mass index (BMI), Ca125 value, history of infertility and breast cancer, type of surgery and postoperative pathology results.RESULTS: The mean age of the patients included in the study was 45.5±5.8, BMI was 27.6±5.4kg/m2, Ca125 value was 17.9±14.1IU/ml, and 79.2% of the patients had a history of breast cancer. A total of 62.5% patients had BRCA1 and 37.5% had BRCA2 gene mutations. There was no statistically difference found between the two groups in terms of age, number of pregnancies and births, BMI, Ca125 value, history of infertility and breast cancer, type of surgery and postoperative pathology (p>0.05). As a result of the postoperative pathological evaluation, ovarian cancer was detected in one patient (in the BRCA1 group).CONCLUSIONS: There is no difference in terms of demographic and medical characteristics between patients with BRCA1 and BRCA2 gene mutations, and it should be kept in mind that malignancy may be found as a result of the final pathology.

Keywords:

Cancer, Prophylaxis,

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