Seda ÇELİK, Duygu Mine YAVUZ, Ergin TAŞKIN, Fatih BOY, Fatih KARA

HEMATOKRİTE GÖRE DÜZELTİLMİŞ ERİTROSİT SEDİMENTASYON HIZI, C-REAKTİF PROTEİN İLE DAHA İYİ BİR KORELASYONA SAHİPTİR

AMAÇ: Eritrosit sedimentasyon hızı (ESR) klinik uygulamada yaygın olarak kullanılan bir laboratuvar belirtecidir. ESR, temel olarak iki faktörden etkilenir: fibrinojen gibi plazma proteinleri ve hematokrit gibi eritrositler ile ilişkili bazı durumlar. Hematokritin ESR üzerindeki etkisini ortadan kaldırarak ESR'yi yorumlayabilmek için bazı formüller geliştirilmiştir. Bu çalışmanın amacı, hematokrite göre düzeltilmiş ESR formüllerinin C-reaktif protein (CRP) ile daha iyi bir korelasyonunun olup olmadığını belirlemekti.GEREÇ VE YÖNTEM: Hastanemiz veri tabanından Şubat 2018'e ait veriler alındı. Aynı anda elde edilen kan örneklerinde ölçülen ESR, CRP ve hematokrit değerlerine ait toplam 1206 hastanın sonuçları, bu parametreler arasında bir korelasyon olup olmadığı açısından analiz edildi. Hematokrite göre düzeltilmiş ESR değerleri, aşağıdaki formüllerle hesaplandı: (a) Hematokrite göre düzeltilmiş sedimentasyon-1 (HA-ESR-1) = [(15)/(55-hematokrit)]X sedimentasyon, (b) Hematokrite göre düzeltilmiş sedimentasyon- 2 (HA-ESR-2) = (hematokrit/45)X sedimentasyon.BULGULAR: HA-ESR-2 standart ESR ölçümlerine kıyasla CRP ile daha iyi bir korelasyona sahipti, ancak HA-ESR-1, CRP ve ESR arasındaki ilişkiyi iyileştiremedi.SONUÇ: HA-ESR-2'nin CRP ile standart ESR'den anlamlı olarak daha iyi bir korelasyon gösterdiğini bulduk. Bu nedenle, söz konusu formül klinik uygulamada yararlı olabilir.

Anahtar Kelimeler:

Eritrosit Sedimentasyon Hızı, Hematokrit, C-Reaktif Protein

HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN

OBJECTIVE: Erythrocyte sedimentation rate (ESR) is a laboratory marker widely used in clinical practice. It is affected primarily by two factors following: plasma proteins such as fibrinogen and some conditions associated with the erythrocytes such as hematocrit. Some formulas have been developed so as to interpret the ESR by eliminating the effect on the ESR of the hematocrit. The purpose of our research was to determine whether the formulas for ESR adjusted with hematocrit levels have a better correlation with C-reactive protein (CRP).MATERIAL AND METHODS: The data belong to February 2018 were obtained from database of our hospital. A total of 1206 patients’ results including ESR, CRP, and hematocrit, which had been measured in blood samples simultaneously obtained, were analyzed in terms of whether there is a correlation between these parameters. Hematocrit-adjusted ESR values were calculated by formulas following: (a) Hematocrit-adjusted sedimentation-1 (HA-ESR-1) = [(15)/(55-hematocrit)]X sedimentation, (b) Hematocrit-adjusted sedimentation-2 (HA-ESR-2) = (hematocrit/45)X sedimentation.RESULTS: While HA-ESR-2 had a better correlation with CRP compared to standard ESR measurements, HA-ESR-1 didn't make good the association between CRP and ESR.CONCLUSIONS: We found that HA-ESR-2 has significantly a better correlation with CRP than that of standard ESR. Therefore, this formula may be useful in clinical practice.

Keywords:

Erythrocyte Sedimentation Rate, Hematocrit, C-Reactive Protein,

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