Ayşe ÖZDEMİR, Utku Dönem DİLLİ, Dalyan ÖZDEMİR, Salim NEŞELİOĞLU, Özcan EREL

MEME KANSERLİ HASTALARDA DİNAMİK TİYOL, DİSÜLFİT DENGESİ İLE CA-15-3 SEVİYELERİ ARASINDAKİ İLİŞKİ

AMAÇ: Tiyol/disülfit dengesi birçok hastalıkta önemli bir oksidatif belirteçtir. Kanserli olgularda biyo-belirteç olması yönünde çalışmalar yapılmaktadır. Bu çalışmanın amacı meme kanserli hastalarda tiyol-disülfid homeosta-zisi (Dinamik tiyol [-SH], disülfit [-S-S] ve total tiyol [TT] ) ile CA 15-3 (kanser antijeni 15-3) ve CEA [karsinoembri-yojenik antijen], IMA[iskemik modifiye albümin], albümin arasındaki ilişkiyi araştırmak ve literatürde ilk kez yapılan sağlıklı kontrollerle karşılaştırmaktır. GEREÇ VE YÖNTEM:Hastalar kemoterapi altında çalış-maya katıldılar. Çalışma prospektif bir çalışmadır. Çalış-maya 39 kanserli hasta ve 41 sağlıklı toplamda 80 hasta dahil edildi. Çalışmamızda, tiyol-disülfid homeostazisin-deki değişiklikler ve IMA, Albumin, CA 15-3 seviyelerine bakıldı. BULGULAR:Kontrol ile meme CA grupları arasında IMA, albumin ve CA-15-3 açısından istatiksel olarak anlamlı fark olduğu belirlendi (p

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