KORONER ARTER BYPASS CERRAHİSİNDE LOSARTAN’ IN İNTERNAL TORASİK ARTER, RADİAL ARTER VE SAFEN VEN GREFTLERİNDEKİ NİTRİK OKSİT DÜZEYİNE ETKİSİ

Amaç: Koroner arter cerrahisinde greft açık kalma süresi endotel fonksiyonuna bağlıdır. Nitrik Oksitin (NO) endotel fonksiyonuna yararlı etkisibilinmektedir. Greftlerdeki Nitrik Oksit düzeyi ve Losartan’ın Nitrik Oksit üzerine etkisi invitro olarak araştırılmıştır.Yöntem: Çalışma 13 hasta da 78 örnek ile yapıldı. İnternaltorasik arter, radial arter ve safenvengreft örnekleri “Kontrol Grubu” ve “LosartanGrubu” olmak üzere ikiye ayrıldı. Losartan grubu örnekleri 1 x 10-5molar Losantanlı Troyde’s solüsyonu çözeltisi içinde inkübe edildi. NitrikOksit, Griess yöntemi kullanılarak ölçüldü. İstatistiksel değerlendirme. Kruskal Wallis Oneway ANOVA, İndependentsample T ile Tukey veBonferroni testleri kullanılarak yapıldı.Bulgular: Kontrol grubu bazal Nitrik Oksit değeri, internaltorasik arter greftinde anlamlı olarak yüksek bulunmuştur (p

THE EFFECT OF LOSARTAN ON THE LEVELS OF NITRIC OXIDE IN INTERNAL THORACIC ARTERY, RADIAL ARTERY AND SAPHENOUS VEN GRAFTS IN CORONARY ARTERY BYPASS SURGERY

Objective: Graft exposure time in coronary artery surgery depends on endothelial function. The beneficial effect of nitricoxide on endothelial function is known. Nitricoxide level in grafts and the effect of Losartan on nitricoxide were investigated as in vitro. Methods: The study was carried out with 78 samples in 13 patients. Internal thoracic artery, radial artery and saphenous vein graft samples were divided into "Control Group" and "Losartan Group". Statistical evaluation was performed using Kruskal Wallis Oneway ANOVA, Independent sample T, Tukey and Bonferroni tests. Results: The baseline Nitric Oxide value in the control group was significantly higher in the internal thoracic artery graft (p

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