Sibel Gökçay BEK, Necmi EREN, Betül Kalender GÖNÜLLÜ, Serkan BAKIRDÖĞEN, Berna ÜSTÜNER

HEPCİDİN VE VİTAMİN D: KRONİK BÖBREK HASTALIĞI ANEMİSİNDE KARŞILIKLI ETKİLEŞİM

Amaç: Hepsidin, kronik böbrek hastalığı (KBH) dahil olmak üzere kronik inflamatuar hastalarda serum seviyesi artan büyük oranda karaciğerde sentezlenen bir peptiddir. Amacımız, hepsidin ve KBH anemisinin düzenlenmesinde D vitamininin rolünü tartışmaktır. Yöntem: Çalışma grubuna 103 KBH'li hasta ve 59 sağlıklı birey dahil edildi. Hepsidinin serum konsantrasyonu ELISA kullanılarak ölçüldü ve aşağıdaki faktörlerle ilişki değerlendirildi: yaş, cinsiyet, vücut kitle indeksi, böbrek fonksiyonları (tahmini glomerüler filtrasyon hızı, eGFR), ilaç geçmişi, serum biyokimyası, tam kan sayımı, demir ve toplam demir bağlama kapasitesi, ferritin, D vitamini, yüksek duyarlı C-reaktif protein, Creaktif protein ve eritrosit sedimantasyon hızı (ESR). Bulgular: KBH grubunun ortalama yaşı 58,63 ± 11,8 yıldı ve sırasıyla 16, 26, 27, 19 ve 15 hasta; her bir kronik böbrek hastalığı evresinde, I'den V'ye ve dokuz hemodiyalizde, altı periton diyalizinde hasta tespit edildi. KBH’da ortalama hepsidin konsantrasyonu (30,3 ± 24.7 ng / ml), kontrol (17,8 ± 8,4 ng / ml) grubundan daha yüksek bulundu (p

HEPCIDIN AND VITAMIN D LEVELS: MUTUAL EFFECTS IN ANEMIA OF CHRONIC KIDNEY DISEASE

Objective: Hepcidin is a peptide with anti-microbial properties that is largely synthesized in the liver and has important roles in iron homeostasis,with serum levels elevated in chronic inflammatory conditions, including chronic kidney disease (CKD). Our aim was to discuss on the role ofvitamin D in regulation of hepcidin and anemia of CKD.Methods: The study group included 103 patients with CKD and 59 healthy individuals. The serum concentration of hepcidin was measured usingELISA, and the association to the following factors was evaluated: age, sex, body mass index, renal functions (estimated glomerular filtration rate,eGFR), drug history, serum biochemistry, complete blood count, iron and total iron binding capacity, ferritin, vitamin D, high sensitive C-reactiveprotein, C-reactive protein, and the erythrocyte sedimentation rate.Results: The mean age of the CKD group was 58.63 ± 11.8 years (with 16, 26, 27, 19, and 15 patients; respectively in each chronic kidney diseasestage, from I through V and nine on haemodialysis, six on peritoneal dialysis). The mean hepcidin concentration was higher in the chronic kidneydisease (30.3±24.7 ng/ml) than control (17.8 ± 8.4ng/ml) group (p

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