The Effectiveness of Neutrophil/Lymphocyte Ratio in Hospitalization of Childhood Viral Gastroenteritis

INTRODUCTION: Acute gastroenteritis is an inflammatory disease. Neutrophil/lymphocyte ratio (NLR), one of the inflammation biomarkers, may be compatible with the severity of the disease in patients with acute gastroenteritis. In this study, we aimed to determine whether NLR in the blood has an effect on hospitalization in children with acute gastroenteritis with rota and / or adenovirus antigen positivity in the stool. METHODS: Between January 2018 and January 2019, 438 children admitted to the emergency department due to acute gastroenteritis and who were found to have rota and / or adenovirus antigen positivity were examined retrospectively. RESULTS: 438 children with rota and / or adenovirus antigen positive in their stool were included in the study. There was a statistically significant difference between NLO and hospitalization of patients as well as between groups (p

Çocukluk Çağı Viral Gastroenteritlerin Hastane Yatışlarında Nötrofil/Lenfosit Ora nının Etkinliği

GİRİŞ ve AMAÇ: Akut gastroenterit inflamatuar bir hastalıktır. İnflamasyon biyobelirteçlerinden biri olan nötrofil/lenfosit oranı (NLO) akut gastroenteritli hastalarda hastalığın ciddiyeti ile uyumlu olabilir. Bu çalışmada dışkıda rota ve/veya adeno virüs antijen pozitifliği olan akut gastroenteritli çocuklarda kanda NLO’nun servis yatışına etkisinin olup olmadığının belirlenmesi amaçlanmıştır. YÖNTEM ve GEREÇLER: Bu çalışmada Ocak 2018 ile Ocak 2019 tarihleri arasında akut gastroenterit nedeniyle acil servise başvuran ve dışkıda rota ve/veya adeno virüs antijeni pozitifliği saptanan 438 çocuk hasta retrospektif olarak incelendi. BULGULAR: Çalışmaya dışkıda rota ve/veya adeno virüs antijeni pozitif olan 438 çocuk dahil edildi. NLO ile hastaların hospitalizasyonu arasında da gruplar arasında istatiksel olarak anlamlı bir fark bulunmaktadır (p

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1. Cheryl S.Y. Li, Paul K.S. Chan, Julian W. Tang. Prevalance of diarrhea viruses in hospitalized children in Hong Kong in 2008. J Med Virol 2009; 81:1903-11.

2. King CK, Glass R, Bresee JS, Duggan C; Centers for Disease Control and Prevention. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. MMWR Recomm Rep. 2003;52(RR-16):1-16.

3. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani BG, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 2010; 375: 1969-87.

4. Rosenfeldt V, Vesikari T, Pang XL, Zeng SQ, Tvede M, Paerregaard A. Viral etiology and incidence of acute gastroenteritis in young children attending day-care centers. Pediatr Infect Dis J 2005; 24:962-5.

5. Bresee JS, Parashar UD, Widdowson MA, Gentsch JR, Steele AD, Glass RI. Update on rotavirus vaccines. Pediatr Infect Dis J 2005; 24: 947-52.

6. Ehlken B, Laubereau B, Karmaus W, Petersen G, Rohwedder A, Forster J and the RoMoD Study Group. Prospective population-based study on rotavirüs disease in Germany. Acta Paediatrica 2002;91:769-775.

7. Pickering LK. Summaries of infectious Diseases, Adenovirüs infections. In: Pickering LK Ed. American Academy of Pediatrics Red Book, New York: Elk Grove Co, 2003;90-192.

8. Kapci M, Turkdogan KA, Duman A, Avcil M, Gülen B, Kuçukdagli OT, et.al. Biomarkers in the diagnosis of acute appendicitis. JCEI 2014;5:250-255.

9. Zahorec R. Ratio of neutrophil to lymphocyte countsRapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001; 102: 5-14.

10. Chen Q, Yang LX, Li XD, Yin D, Shi SM, Chen EB, et al. The elevated preoperative neutrophil-to-lymphocyte ratio predicts poor prognosis in intrahepatic cholangiocarcinoma patients undergoing hepatectomy Tumor Biol. 2015;36(7):5283–9.

11. TürkDagi H, Fındık D. Akut gastroenteritli hastalarda rotavirüs ve adenovirüs antijenlerinin araştırılması. J Clin Exp Invest 2014;5:256-260.

12. Sánchez-Fauquier A, Montero V, Moreno S, Sole M, Colomina J, Gomara MI, et al. Human rotavirus G9 and G3 as major cause of diarrhea in hospitalized children, Spain. Emerg Infect Dis 2006;12:1536-1541.

13. Tayeb HT, Balkhy HH, Aljuhani SM, Elbanyan E. Increased prevalence of rotavirus among children associated gastroenteritis in Riyadh Saudi Arabia. Virology Journal 2011;8:548.

14. Cruz JR, Cáceres P, Cano F, Flores J, Bartlett A, Torun B, et al. Adenovirus types 40 and 41 and rotaviruses associated with diarrhea in children from Guatemala. J Clin Microbiol 1990;28:1780-1784.

15. Ceyhan M, Alhan E, Salman N, Kurugol Z, Yildirim I, Celik U, et al. Multicenter prospective study on the burden of rotavirus gastroenteritis in Turkey, 2005-2006: a hospital-based study. J Infect Dis. 2009; 200 Suppl 1: 234-8 .

16. Yousefi Rad A, Gözalan A. Detection of rotavirus and enteric adenovirus antigens in outpatients with gastroenteritis. Türkiye Klinikleri J Med Sci 2010;30:174- 179.

17. Crawford SE, Ramani S, Tate JE, Parashar UD, Svensson L, Hagbom M, et al. Rotavirus infection. Nat Rev Dis 2018;9:3.

18. Junaid SA, Umeh C, Olabode AO, Banda JM. Incidence of rotavirus infection in children with gastroenteritis attending Jos university teaching hospital. Nigeria. Virol J 2011;8:233.

19. Parashar UD, Nelson EAS, Kang G. Diagnosis, management, and prevention of rotavirus gastroenteritis in children. BMJ 2013;30;347:f7204.

20. Jaha VI, Shala M, Azemi M, Hoxa-Kanberi T, Avdiu M, Spahiu S, et al. Characteristics of Rotavirus Diarrhea in Hospitalized Children in Kosovo Materia Socio Medica 2014;26:335-8.

21. Nitsch-Osuch A, Kuchar E, Kosmala A, Życinska K, Wardyn K. Nosocomial rotavirus gastroenterocolitis in a large tertiary pediatric hospital in Warsaw, 2006-2010. Arch Med Sci 2013;9:493-8.

22. Damme PV, Giaquinto C, Huet F, Gothefors L, Maxwell M, Wielen MV, et al. Multicenter Prospective Study of the Burden of Rotavirus Acute Gastroenteritis in Europe 2004 – 2005: The Reveal Study. J Infect Dis 2007;195:S4–S16.

23. Nakanishia K, Tsugawab T, Honmaa S, Nakata S,Tatsumi M,Yoto Y, et al. Detection of enteric viruses in rectal swabs from children with acute gastroenteritis attending the pediatric outpatient clinics in Sapporo. Japan J Clin Virology 2009;46:94-7.

24. Constenla D, Velazquez FR, Rheingans RD, Antil L, Cervantes Y. Economic Impact of a Rotavirus Vaccination Program in Mexico. Rev Panam Salud Publica 2009; 25: 481-90.

25. Pichler M, Hutterer GC, Stoeckigt C, Chromecki TF, Stojakovic T, Golbeck S, et al. Validation of the pre-treatment neutrophil-lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients. Br J Cancer 2013;108:901-907.

26. Templeton AJ, Ace O, McNamara MG, Mubarak MA, Badillo FV, Hermanns T, et al. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2014;23:1204-1212.

27. Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutro- phils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011;11:519-531.

28. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and out- comes in patients with acute coronary syndrome. Am J Car- diol 2008;102:653-657.

29. Celikbilek M, Dogan S, Ozbakir O, Zararsiz G, Kücük H, Gürsoy S, et al. Neutrophil-lym- phocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal 2013;27:72-76.

30. Ozturk ZA, Kuyumcu ME, Yesil Y, Savas E, Yildiz H, Kepekci Y, et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients? J Endocrinol Invest 2013;36:593-599.

31. Gunbatar H, Ekin S, Sunnetcioglu A, Arisoy A, Cilingir BM, Asker S, et.al. The relation- ship between neutrophil-to-lymphocyte ratio and platelet- to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. Dicle Med J 2015;42:289-293.

32. Hu ZD, Sun Y, Guo J, Huang YL, Quin BD, Gao Q, et al. Red blood cell distribution width and neutrophil/lymphocyte ratio are positively corre- lated with disease activity in primary Sjogren’s syndrome. CLB 2014;47:287-290.

33. Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H, et al. Neutrophil to lymphocyte ra- tio (NLR), platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and dis- ease activity in SLE patients. Mod Rheumatol 2015:1; 5-8.
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  • ISSN: 2147-0758
  • Başlangıç: 2012
  • Yayıncı: -
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