Prohepcidin levels in Familial Mediterranean Fever: Possible effect of iron metabolism?

INTRODUCTION: Familial Mediterranean Fever (FMF) is a systemic autoinflammatory disorder. Hepcidin is an acid peptide mainly involved in iron regulation that increases by inflammation and infection. In this study; we aimed to evaluate the relationship between the hepcidin levels and FMF attacks, and to determine the likely role of hepcidin in the diagnosis of the disease. METHODS: 42 male patients and 28 healthy male controls were included in the study. Prohepcidin, interleukin-6 (IL-6), serum iron, serum iron binding capacity, ferritin, fibrinogen and erythrocyte sedimentation rate were analyzed. RESULTS: Prohepcidin levels was significantly lower in patient group than control group, wheras IL-6 levels was significantly higher (p

Ailesel Akdeniz Ateşinde prohepsidin seviyeleri: Demir metabolizmasının rolü var mı?

GİRİŞ ve AMAÇ: Ailesel Akdeniz Ateşi sistemik otoinflamatuar bir hastalıktır. Hepsidin ise demir metabolizamasında rol oynayan inflamasyon ve enfeksiyonda yükselen bir peptiddir. Biz çalışmamızda Ailesel Akdeniz Ateşi ataklarında hepsidin düzeylerini ve hastalık patogenezinde hepsidinin olası rolünü araştırmayı hedefledik. YÖNTEM ve GEREÇLER: Çalışmamıza 42 erkek hasta ve 28 erkek kontrol dahil edildi. Hastaların ataklı ve ataksız dönemlerinden ve kontrol hastalarından prohepsidin, interlökin-6, serum demiri, serum demir bağlama kapasitesi, ferritin, fibrinojen ve eritrosit sedimantasyon oranı değerleri analiz edildi. BULGULAR: Hasta grubunun serum prohepsidin seviyeleri kontrol grubuna göre düşük iken, IL-6 seviyeleri hasta grubunda anlamlı yüksek saptandı (p

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1. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 1997;40:1879–85.

2. Ozel AM, Demirturk L, Yazgan Y, Avsar K, Gunay A, Gurbuz AK, et al. Familial Mediterranean Fever, A review of the disease and clinical and laboratory findings in 105 patients. Digest Liver Dis 2000;32:504-9.

3. Centola M, Wood G, Frucht DM, Galon J, Aringer M, Farrell J, et al. The gene for Familial Mediterranean Fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. Blood 2000;95:3223–31.

4.The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997;90:797–807.

5. Direskeneli H, Ozdogan H, Korkmaz C, Akoglu T, Yazici H. Serum soluble intracellular adhesion molecule 1 and interleukin 8 levels in familial Mediterranean fever. J Rheumatol 1999;26:1983–6.

6. Mege JL, Dilsen N, Sanguedolce V, Gul A, Bongrand P, Roux H, et al. Overproduction of monocyte derived tumor necrosis factor, interleukin (IL)-6, IL-8 and increased neutrophil superoxide generation in Behcet’s disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol 1993;20:1544–9.

7. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003;102(3):783-8.

8. Shike H, Lauth X, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, et al. Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge. Eur J Biochem 2002;269:2232-7.

9. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T, et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute phase protein. Blood 2003;101:2461-3.

10. Roe MA, Spinks C, Heath AL, Harvey LJ, Foxall R, Wimperis J, et al. Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, in hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women. Br J Nutr 2007;97:544-9.

11. Nagashima M, Kudo M, Chung H, Ishikawa E, Hagiwara S, Nakatani T, et al. Regulatory failure of serum prohepcidin levels in patients with hepatitis C. Hepatol Res 2006;36:288-93.

12. Galon J, Aksentijevich I, McDermott MF, O’Shea JJ, Kastner DL. TNFRSF1A mutations and autoinflammatory syndromes. Current Opinion in Immunology 2000;12:479-86.

13. Ben-Chetrit A, Levy M. Familial Mediterranean fever. Lancet 1998;351:659-664.

14. Chae JJ, Aksentijevich I, Kastner DL. Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy. Br J Haematol 2009;146(5):467-78.

15. Haghigat M, Derakhshan A, Karamifar H. Familial Mediterranean Fever. Shiraz E-medical Journal 2006;7(2):1-16.

16. Ozen S. Famililal Mediterranean fever: revisiting an ancient disease. Eur J Pediatr 2003;162(7/8):449-54.

17. Manukyan GP, Ghazaryan KA, Ktsoyan ZhA, Tatyan MV, Khachatryan ZA, Hakobyan GS, et al. Cytokine profile of Armenian patients with Familial Mediterranean fever. Clin Biochem 2008;41(10- 11):920-2.

18. Baykal Y, Saglam K, Yilmaz MI, Taslipinar A, Akinci SB, Inal A. Serum sIL-2r, IL-6, IL-10 and TNF-alpha level in familial Mediterranean fever patients. Clin Rheumatol 2003;22(2):99-101.

19. Notarnicola C, Didelot MN, Seguret F, Demaille J, Touitou I. Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever. Genes Immun 2002;3(1):43-5.

20. Gang N, Drenth J, Langevitz P, Zemer D, Brezniak N, Pras M, et al. Activation of the cytokine network in familial Mediterranean fever. J Rheumatol 1999;26:890–7.

21. Celkan T, Celik M, Kasapçopur O, Ozkan A, Apak H, Ocak S, et al. The anemia of familial Mediterranean fever disease. Pediatr Hematol Oncol 2005;22(8):657-65.

22. Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, et al. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci U S A 2006 Jun 27;103(26):9982-7.

23. Lachmann HJ, Sengul B, Yavuzsen TU, Booth DR, Booth SE, Bybee A, et al. Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Oxford) 2006 Jun;45(6):746-50.

24. Park CH, Valore EV, Waring AJ, Gant T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-10.

25. Krause A, Neltz S, Magert H, Schulz A, Forssmann WG, Schulz-Knappe P, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antibimcrobial activity. FEBS lett 2000;480(2-3):147-50.

26. Pigeon C, Ylyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-9.

27. Fleming RE, Sly WS. Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. Proc Nati Acad Sci USA 2001;98:8160-2.

28. Ahmad KA, Ahmann JR, Migas MC, Waheed A, Britton RS, Bacon BR, et al. Decreased liver hepcidin expression in the Hfe knockout mice. Blood Cells Mol Dis 2002;29:361-6.
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  • ISSN: 2147-0758
  • Başlangıç: 2012
  • Yayıncı: -
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