Kronik Lenfositik Lösemi Tanılı Hastalarda Vasküler Endotel Büyüme Faktör (VEGF) Düzeylerinin Prognozla İlişkisi

GİRİŞ ve AMAÇ: Rai ve Binet evreleme sistemleri, kronik lenfositik lösemi (KLL)'nin prognozunu değerlendirmek için standart bir yöntem olarak kullanılırlar. Bununla birlikte, KLL klinik özellikler ve prognoz açısından heterojen bir hastalıktır. Rai ve Binet evreleme sistemleri; sağkalım sonuçlarını ve tedaviye cevabı etkileyen KLL hücrelerinin farklı biyolojik özelliklerini yansıtmayabilir. Bu nedenle, son yıllarda yeni prognostik parametreler önemli hale gelmiştir. KLL'deki serum VEGF düzeylerinin, hastalığın ilerlemesini belirlemede önemli bir parametre olabileceği önerilmektedir. YÖNTEM ve GEREÇLER: 46 KLL hastasında ve 20 sağlıklı kontrolde; serum VEGF düzeylerini ELISA yöntemi ile tespit ettik. BULGULAR: KLL hasta grubunda; sağlıklı kontrol grubuna göre daha yüksek ortalama serum VEGF düzeyleri saptandı (sırasıyla; 267 pg / mL, 43,8 pg/mL, p: 267 pg / ml), Binet A ve B KLL hastalarında daha kısa hastalık progresyonu süresi ile ilişkiliydi (p: 0,004). Ayrıca yüksek serum VEGF düzeylerinin OS ile anlamlı korelasyon gösterdiğini saptadık (p: 0,019). TARTIŞMA ve SONUÇ: Sonuç olarak, KLL hastalarındaki serum VEGF düzeylerinin kontrol grubundan daha yüksek olduğunu ve hastalığın ilerlemesi ve sağkalımı ile ilişkili bir parametre olabileceğini bulduk. Bu nedenle; ELISA ile serum VEGF kolay tespit edilmesi, daha büyük ve çok değişkenli çalışmalarda önemi gösterildikten sonra, yararlı bir klinik parametre olabilir.

The Association Between Vascular Endothelial Growth Factor (VEGF) Levels And Prognosis In Patients Chronic Lymphocytic Leukemia

INTRODUCTION: The Rai and Binet staging systems areused as a standard method to evaluate the prognosis of chroniclympocytic leukemia (CLL). However, CLL is a heterogeneousdisease in terms of clinical features and prognosis. The Raiand Binet staging systems; may not reflect the differentbiological properties of CLL cells affecting survival outcomesand response to treatment. Because of this, new prognosticparameters has become important in the recent years. It issuggested that serum VEGF levels in CLL may be an importantparameter in determining the progression of the disease.METHODS: We detected the serum levels of VEGF in 46 CLLpatients and 20 healthy controls with the use of ELİSA method.RESULTS: The CLL patients group had higher median serumlevels of VEGF compared to the control group (267 pg / mL,43,8 pg/mL, p: 267 pg/ml) were associated with ashorter time of disease progression in Binet A and B CLLpatients (p: 0,004). We also found that high serum VEGFlevels showed a significant correlation with OS (p: 0,019).DISCUSSION and CONCLUSION: As a result, we found thatthe serum levels of VEGF in the CLL patients are higher thanthe control group and it can be a parameter associated withthe disease progression and survival. For this reason andbecause the simplicity of analyzing with ELISA, it can be auseful clinical parameter, after its importance have beenshown in larger and multi-variate studies.

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