Koroner arter baypas greftleme sonrası yeni başlangıçlı atrial fibrilasyonda trombosit-lenfosit oranının prediktif değeri

GİRİŞ ve AMAÇ: Yüksek trombosit-lenfosit oranının(TLO) sistemik inflamasyon ve kardiyak mortalite ile ilişkisi bilinmektedir. Koroner arter baypas greftleme (KABG) sonrası yeni başlangıçlı atrial fibrilasyon inflamatuvar süreçlerle ilişkilidir. Bu çalışmada bir inflamasyon belirteci olan TLO’ nun KABG sonrası yeni başlangıçlı atrial fibrilasyon ile ilişkisi araştırıldı. YÖNTEM ve GEREÇLER: Çalışmaya izole KABG uygulanan 245 hasta dahil edildi. Postoperatif atrial fibrilasyon (AF) gelişen 57(23.1%) hasta (AF grup) ve normal sinüs ritminde (NSR grup) takip edilen 188(76.7%) hasta olmak üzere iki gruba ayrıldı. Gruplar arası klinik ve labaratuvar bulgular karşılaştırıldı. Lojistik regresyon modeli oluşturularak postoperatif AF ile değişkenler arasındaki ilişki araştırıldı. BULGULAR: Yüksek yoğunluklu lipoprotein(HDL) ve lenfosit sayısının NSR grubunda anlamlı düzeyde yüksek olduğu(p

Predictive value of platelet-lymphocyte ratio in new-onset atrial fibrillation after coronary artery bypass grafting

INTRODUCTION: High platelet-lymphocyte ratio is an established marker of systemic inflammation and cardiac mortality, while new onset atrial fibrillation (AF) after coronary artery bypass grafting (CABG) is related with inflammatory processes. In this study, we investigated theassociation of platelet-lymphocyte ratio (PLR), a marker of inflammation, with new-onset atrial fibrillation after coronary artery bypass grafting.METHODS: Among a total of 245 participants who underwentisolated CABG, 57 (23.1%) had postoperative atrial fibrillation (AF group) and 188 (76.7%) had normal sinus rhythm (NSR group). Clinical and laboratory parameters were compared between the two groups. The relationship between the development of postoperative AF and the study parameters was investigated by logistic regression analysis.RESULTS: High density lipoprotein (HDL) and lymphocyte count were significantly higher in NSR group (p

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1. Kaireviciute D, Aidietis A, Lip GY. Atrial fibrillation following cardiac surgery: clinical features and preventative strategies. Eur Heart J. 2009 Feb;30(4):410-25.
2. Mitchell L B ; C CS Atrial Fibrillation Guidelines Committee . Canadian Cardiovascular Society atrial fibrillation guidelines 2010: prevention and treatment of atrial fibrillation following cardiac surgery. Can J Cardiol. 2011 ; 27 : 91–7
3. Kaw R , Hernandez AV , Masood I , Gillinov AM , Saliba W, Blackstone EH . Short and long-term mortality associated with new-onset atrial fibrillation after coronary artery bypass grafting: a systematic review and meta-analysis. J Thorac Cardiovasc Surg. 2011;141:1305–12.
4. Çiçek G, Açıkgoz SK, Bozbay M, Altay S, Uğur M, Uluganyan M, et al. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio combination can predict prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Angiology. 2015 May;66(5):441-7.
5. El-Chami MF, Kilgo P, Thourani V, Lattouf OM, Delurgio DB, Guyton RA, et al. New-onset atrial fibrillation predicts long-term mortality after coronary artery bypass graft. J Am Coll Cardiol. 2010;55:1370–6.
6. Creswell LL, Schuessler RB, Rosenbloom M, Cox JL. Hazards of postoperative atrial arrhythmias. Ann Thorac Surg. 1993;56:539–49.
7. Özdin S, Böke Ö. Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in different stages of schizophrenia. Psychiatry Res. 2018 Nov 19;271:131-5.
8. Anatoĺevna RO, Veniaminovich FO, Mikhaylovich KS. Predictors of new-onset atrial fibrillation in elderly patients with coronary artery disease after coronary artery bypass graft. J Geriatr Cardiol. 2016 Jul;13(5):444-9.
9. Ferreira AF, A Saraiva F, Moreira R, J Cerqueira R, J Amorim M, Pinho P, et al. Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting Surgery. Rev Port Cir Cardiotorac Vasc. 2017 Jul-Dec;24(3-4):129.
10. Hidayet Ş, Yağmur J, Bayramoğlu A, Taşolar MH, Kurtoğlu E, Özyalın F. Prediction of postoperative atrial fibrillation with left atrial mechanical functions and NT-pro ANP levels after coronary artery bypass surgery: A three-dimensional echocardiography study. Echocardiography. 2018 May;35(5):661-666.
11. Emren SV, Aldemir M, Ada F. Does Deficiency of Vitamin D Increase New Onset Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery? Heart Surg Forum. 2016 Aug 22;19(4):E180-4.
12. Memetoglu ME, Kehlibar T, Yılmaz M, Günay R, Arslan Y, Tuygun A, et al. Serum uric acid level predicts new-onset atrial fibrillation after coronary artery bypass graft operation. Eur Rev Med Pharmacol Sci. 2015;19(5):784-9.
13. Ramlawi B, Otu H, Mieno S, Boodhwani M, Sodha NR, Clements RT, et al. Oxidative stress and atrial fibrillation after cardiac surgery: a case-control study. Ann Thorac Surg. 2007;84:1166–72.
14. Lo B, Fijnheer R, Nierich AP, Bruins P, Kalkman CJ. C-reactive protein is a risk indicator for atrial fibrillation after myocardial revascularization. Ann Thorac Surg. 2005;79:1530-5.
15. Gibson PH, Cuthbertson BH, Croal BL, Rae D, El-Shafei H, Gibson G, et al. Usefulness of neutrophil/lymphocyte ratio as predictor of newonset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol. 2010;15:186–91.
16. Schenone M, Furie BC, Furie B. The blood coagulation cascade. Curr Opin Hematol. 2004;11:272-7.
17. Kurtul A, Yarlioglues M, Murat SN, Ergun G, Duran M, Kasapkara HA, et al. Usefulness of the platelet tolymphocyte ratio in predicting angiographic reflow after primary percutaneous coronary intervention in patients with acute ST segment elevation myocardial infarction. Am J Cardiol. 2014;114: 342–7.
18. Nikolsky E, Grines CL, Cox DA, Garcia E, Tcheng JE, Sadeghi M, et al. Impact of baseline platelet count in patients undergoing primary percutaneous coronary intervention in acute myocardial infarction (from the CADILLAC trial). Am J Cardiol. 2007;99:1055–61.
19. Azab B, Shah N, Akerman M, McGinn JT. Value of platelet/ lymphocyte ratio as a predictor of all-cause mortality after non-STelevation myocardial infarction. J Thromb Thrombolys. 2012;34: 326–34.
20. Yildiz A, Yuksel M, Oylumlu M, Polat N, Akyuz A, Acet H, et al. The utility of the plateletlymphocyte ratio for predicting no reflow in patients with ST-segment elevation myocardial infarction. Clin Appl Thromb Hemost. 2015 Apr;21(3):223-8.
21. Ayça B, Akin F, Çelik Ö, Yüksel Y, Öztürk D, Tekiner F, et al. Platelet to lymphocyte ratio as a prognostic marker in primary percutaneous coronary intervention. Platelets. 2015;26(7):638-44.
22. Erdem K, Ayhan S, Ozturk S, Bugra O, Bozoglan O, Dursin H, et al. Usefulness of the mean platelet volume for predicting new-onset atrial fibrillation after isolated coronary artery bypass grafting. Platelets. 2014;25(1):23-6.
23. El-Chami MF, Kilgo P, Thourani V, Lattouf OM, Delurgio DB, Guyton RA, et al. New-onset atrial fibrillation predicts long-term mortality after coronary artery bypass graft. J Am Coll Cardiol. 2010 Mar 30;55(13):1370-6.