Kadri Murat GURSES, Zafer BÜYÜKTERZİ, Mehmet Akif BOR, Ahmet Lütfi SERTDEMİR, Pelin ALBAYRAK, Mehmet Sertaç APAYDIN, Sami ERDEM

Akut Koroner Sendromlu Hastalarda Ortalama Nötrofil Hacmi Artar

GİRİŞ ve AMAÇ: Nötrofiller akut koroner sendromların (AKS) erken döneminde anahtar rol oynayan inflamatuvar hücrelerdir. Geçmiş çalışmalar, AKS’de dolaşımdaki nötrofil miktarı ile ilişkili değişkenlerde artış olduğunu ortaya koymuştur. Ortalama nötrofil hacmi (ONH) nötrofil aktivasyonunun yeni bir belirteci olarak kabul edilmektedir. Bu çalışmada, AKS hastalarında ONH değerlerinin incelenmesi hedeflenmiştir. YÖNTEM ve GEREÇLER: Mayıs-Ağustos 2016 tarihleri arasında iskemi değerlendirmesini takiben stabil koroner arter hastalığı (SKAH) ön tanısı alan ve elektif koroner anjiyografi uygulanan hastalar (n=82) ile; bu hastalarla yaş ve cinsiyet açısından eşlenik, AKS nedeniyle acil koroner anjiyografi yapılan hastalar (n=39) çalışmaya dahil edilmiştir. Elektif koroner anjiyografi uygulanan hastalardan 40’ında epikardiyal koroner arterler normal olarak bulunmuş ve bu hastalar kontrol grubu olarak kabul edilmiştir. Kalan 42 hasta ise SKAH grubunu oluşturmuştur. BULGULAR: Çalışmaya toplam 121 hasta (ortalama yaş 61.18 yıl, %49.59 erkek) dahil edilmiştir. Beyaz küre sayıları (p=0.485) gruplar arasında farklılık göstermemiştir. ONH değerleri, AKS grubunda hem kontrol grubuna, hem de SKAH grubuna kıyasla anlamlı şekilde artmış olarak bulundu (her ikisi için p

Mean neutrophil volume is elevated in patients suffering from acute coronary syndrome

INTRODUCTION: Neutrophils are the key inflammatory cellsin the acute phase of myocardial infarction(MI). Parametersrelated to absolute or relative number of circulating neutrophils have been reported to be increased in previous studies. Mean neutrophil volume(MNV) has emerged as a new marker of activated neutrophils. In this study, we aimed to evaluate MNV in subjects suffering from myocardial infarction.METHODS: For this purpose, we included age and gendermatched consecutive patients undergoing either elective coronary angiography following ischemia- guided assessment of patients with stable coronary artery disease (SCAD) (n= 82) or percutaneous coronary angiography due to MI(Group 3, n= 39) between May- August 2016. Among those undergoing elective coronary angiography, 40 patients were found to have normal epicardial coronary arteries(Group 1) and remaining 42 patients were classified as SCAD group(Group 2).RESULTS: A total of 121 subjects(mean age 61.18 years, 49.59% male) were recruited in this study. White blood cell count (p= 0.485) did not differ among three groups. MNV was found to be significantly elevated in Group 3 (174.80 [9.30]), compared to both Group 1 (147.40 [14.80]) (p< 0.001) and 2 (162.30 [14.72]) (p< 0.001). MNV was also significantly higher in Group 2 when compared to Group 1(p< 0.001).DISCUSSION AND CONCLUSION: Our findings suggest that neutrophil composition shows alterations in MI in the lack of quantitative changes. The spectrum of morphological changes in neutrophils, expressed in terms of MNV, merits further evaluation for its predictive value for early diagnosis of ACS and the extent of post- MI ischemic damage.

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