INTRODUCTION: Optical coherence tomography (OCT) is a non-invasive ocular imaging technique widely used nowadays. There are limited studies focusing on the OCT findings in PD patients. Our aim is to compare retinal changes of peritoneal dialysis (PD) patients with healthy control group by using OCT and investigate the effects of age, gender and duration of PD on these parameters. METHODS: In this cross-sectional study right and left eyes of 32 patients and twenty right and left eyes of ten healthy controls were included. Detailed ophthalmological examinations with central macular thickness (CMT), peripapillary retinal nerve fiber layer (RNFL) thickness, and choroidal thickness (using EDI-OCT) were measured. Macular thickness was measured at five different areas: central,superior, temporal, inferior and nasal. The peripapillary RNFL thickness was analysed in six different areas: temporal, inferotemporal, inferonasal, nasal, superonasal and superotemporal. RESULTS: Sixty-four eyes of 32 patients (18 males, 14 females; aged 20 to 60 years, mean 48.67±12.25 years) with a mean duration of PD of 46.80 months were included. There was a significant difference of macular thickness in the central, temporal, nasal, inferior and superior quadrants between controls and PD patients (p < 0.05). Vitamin D3 supplementation was linked to decreased macular thickness in central, temporal, superior, nasal and inferior quadrants (p
GİRİŞ ve AMAÇ: OCT(Optik koherens tomografi), günümüzde yaygın olarak kullanılan non-invaziv bir oküler görüntüleme tekniğidir. PD hastalarinda OCT bulgularinin değerlendirildiği sınırlı sayıda çalışma vardır. Bu calismada amacımız optik koherens tomografi (OKT) ile periton diyalizi (PD) hastalarının retina değişikliklerini sağlıklı kontrol grubu ile karşılaştırmak ve PD'nin yaş, cinsiyet ve süresinin bu parametrelere etkisinin araştırılmasıdir YÖNTEM ve GEREÇLER: Bu kesitsel çalışmaya 32 hastanın sağ ve sol gözü ve 10 sağlıklı kontrolün yirmi sağ ve sol gözü değerlendirildi. Santral maküla kalınlığı (CMT), peripapiller retina sinir lifi tabakası (RSLT) kalınlığı ve koroid kalınlığı (EDI-OCT kullanılarak) ile detaylı oftalmolojik muayeneler ölçüldü. Makula kalınlığı beş farklı alanda ölçüldü: merkezi, üst, temporal, alt ve nazal. Peripapiller RSLT kalınlığı altı farklı alanda (temporal, inferotemporal, inferonasal, nazal, superiornasal ve superiortemporal) analiz edildi. BULGULAR: Ortalama PD süresi 46,80 ay olan 32 hastanın (18 erkek, 14 kadın; 20-60 yaş, ortalama 48,67 ± 12,25 yıl) 64 gözü çalışmaya alındı. Kontroller ve PD hastaları arasında santral, temporal, nazal, inferior ve superior kadranlarda maküla kalınlığı açısından anlamlı farklılık vardı (p
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1- Varma R, Bazzaz S, Lai M. Optical tomographymeasured retinal nerve fiber layer thickness in normal Latinos. Invest Ophthalmol Vis Sci. 2003; 44: 3369-3373.
2- Chen TC, Zeng A, Sun W, Mujat M, de Boer JF. Spectral domain optical coherence tomography and glaucoma. Int Ophthalmol Clin. 2008; 48: 29-45.
3- Soltan-Sanjari M, Parvaresh MM, Maleki A, Ghasemi-FalavarjaniK, Bakhtiari P. Correlation between retinal nerve fiber layer thickness by optical coherence tomography and perimetric parameters in optic atrophy. J Ophthalmic Vis Res. 2008;3:91-94.
4- Balmforth C, Van Bragt J, Ruijs T, Cameron J et al. Chorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction. JCI Insight. 2016; 1(20): e89173.
5- Sun Z, Tang F, Wong R, et al. OCT Angiography Metrics Predict Progression of Diabetic Retinopathy and Development of Diabetic Macular Edema: A Prospective Study. Ophthalmology. 2019; 126(12): 1675-1684.
6- Rougier MB, Korobelnik JF, Malet F, et al. Retinal nerve fibre layer thickness measured with SDOCT in a population-based study of French elderly subjects: the A lienor study. Acta Ophthalmol. 2015; 13: 539-545.
7- Chung SE, Kang SW, Lee JH, Kim YT. Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration. Ophthalmology. 2011; 118: 840–845.
8- Esmaeelpour M, Povazay B, Hermann B, Hofer B, Kajic V, Hale SL, North RV et al. Mapping choroidal and retinal thickness variation in type 2 diabetes using three-dimensional 1060-nm optical coherence tomography. Invest Ophthalmol Vis Sci. 2011; 52: 5311-5316.
9- Chhablani PP, Ambiya V, Nair AG, Bondalapati S, Chhablani J. Retinal findings on OCT in systemic conditions. Seminars in Ophthalmology. Jun 21, 2017, 1-22.
10- Mullaem G, Rosner MH. Ocular problems in the patient with end-stage renal failure. Semin Dial. 2012; 25: 403-407.
11- Haider S, Astbury NJ, Hamilton DV. Optic neuropathy in uraemic patients on dialysis. Eye (Lond). 1993; 7: 148-151.
12- Saini JS, Jain IS, Dhar S, Mohan K. Uremic optic neuropathy. J Clin Neuroophthalmol. 1989; 9: 131-135.
13- Niutta A, Spicci D, Barcaroli I. Flouroangiographic findings in hemodialyzed patients. Ann Ophthalmol. 1993; 25: 375-380.
14- Tokuyama T, Ikeda T, Sato K. Effects of haemodialysis on diabetic macular leakage. Br J Ophthalmol. 2000; 84: 1397-1400.
15- Demir MN, Eksioğlu U, Altay M, Tok O, Yilmaz FG, Acar MA. Retinal nerve fiber layer thickness in chronic renal failure without diabetes mellitus. Eur J Ophthalmol. 2009; 19: 1034-1038.
16- Pahor D. Retinal light sensitivity in haemodialysis patients. Eye (Lond). 2003; 17: 177- 182.
17- Chong KL, Samsudin A, Keng TC, Kamalden TA, Ramli N. Effect of Nocturnal Intermittent Peritoneal Dialysis on Intraocular Pressure and Anterior Segment Optical Coherence Tomography Parameters J Glaucoma. 2017;26:e37–e40
18- Sahin SB, Sahin OZ, Ayaz T, et al. The relationship between retinal nerve fiber layer thickness and carotid intima media thickness in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2014;106:583–589.
19- Lim MC, Tanimoto SA, Furlani BA, et al. Effect of diabetic retinopathy and panretinal photocoagulation on retinal nerve fiber layer and optic nerve appearance. Arch Ophthalmol. 2009;127:857- 862.
20- Demir M, Oba E, Sensoz H, Ozdal E. Retinal nerve fiber layer and ganglion cell complex thickness in patients with type 2 diabetes mellitus. Indian J Ophthalmol. 2014;62:719–720.
21- Annweiler C, Beauchet O, Bartha R, Graffe A, Milea D, Montero-Odasso M. Association between serum 25-hydroxyvitamin D concentration and optic chiasm volume. J Am Geriatr Soc. 2013; 61: 1026- 1028.
22- Beauchet O, Milea D, Graffe A, Fantino B, Annweiler C. Association between serum 25- hydroxyvitamin D concentrations and vision: a crosssectional population-based study of older adults. J Am Geriatr Soc. 2011; 59: 568-570.
23- Van Dijk HW, Kok PHB, Garvin M, et al. Selective loss of iner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy. Invest Ophthalmol Vis Sci. 2009; 50: 3404–3409.
24- Ajtony C, Balla Z, Somoskeoy S, Kovacs B. Relationship between visual field sensitivity and retinal nerve fiber layer thickness as measured by optical coherence tomography. Invest Ophthalmol Vis Sci. 2007; 48: 258-263.
25- Patrick PA, Visintainer PF, Shi Q, Weiss IA, Brand DA. Vitamin D and retinopathy in adults with diabetes mellitus. Arch Ophthalmol. 2012; 130: 756- 760.
26- Krefting EA, Jorde R, Christoffersen T, Grimnes G. Vitamin D and intra ocular pressureresults from a case-control and an intervention study. Acta Ophthalmol. 2014; 92: 345–349.
27- Singh A, Falk MK, Subhi Y, Sørensen TL. The association between plasma 25 hydroxyvitamin D and subgroups in agerelated macular degeneration: a cross-sectional study. PloS One. 2013; 8: 70948. doi: 10.1371/journal.pone.0070948. Print 2013
28- Wang Y, Chiang YH, Su TP, et al. Vitamin D3 attenuates cortical infarction induced by middle cerebral arterial ligation in rats. Neuropharmacology. 2000; 39: 873-880.
29- Annweiler C, Schott AM, Berrut G, et al. Vitamin D and ageing: neurological issues. Neuropsychobiology. 2010; 62: 139-150.
30- Golan S, Shalev V, Treister G, Chodick G, Loewenstein A. Reconsidering the connection between vitamin D levels and age-related macular degeneration. Eye. 2011; 25: 1122-1129.
31- Uro M, Beauchet O, Cherif M, Graffe A, Milea D, Annweiler C. Age-Related Vitamin D Deficiency Is Associated with Reduced Macular Ganglion Cell Complex: A Cross-Sectional HighDefinition Optical Coherence Tomography Study. PLoS One. 2015 Jun 19; 10(6): e0130879