Non-Alkolik Yağlı Karaciğer Hastalığı Olan ve Olmayan Obez Çocuklarda Hepatik Vasküler Akım Değişikliklerinin Değerlendirilmesi

Amaç: Non-alkolik yağlı karaciğer hastalığı olan ve olmayan obez çocuklarda hepatik vasküler akım değişikliklerini Doppler ultrason ile değerlendirmektir.

EVALUATION OF HEPATIC VASCULAR FLOW ALTERATIONS IN OBESE CHILDREN WITH AND WITHOUT NON-ALCOHOLIC FATTY LIVER DISEASE

Objective: To evaluate hepatic vascular flow alterations using Doppler ultrasound in obese children with and without non-alcoholic fatty liver disease.

___

  • 1. Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ. Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 2018;24(7):908-22.
  • 2. Akcam M, Boyaci A, Pirgon O, Koroglu M, Dundar BN. Importance of the liver ultrasound scores in pubertal obese children with nonalcoholic fatty liver disease. Clin Imaging. 2013;37(3):504-8.
  • 3. Mosca A, Panera N, Crudele A, Alisi A. Noninvasive diagnostic tools for pediatric NAFLD: where are we now? Expert Rev Gastroenterol Hepatol. 2020:14(11):1035-46.
  • 4. Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism. 2016;65(8):1038-48.
  • 5. Francque S, Laleman W, Verbeke L, Van Steenkiste C, Casteleyn C, Kwanten W et al. Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture. Lab Investig. 2012;92(10):1428-39.
  • 6. Francque S, Verrijken A, Mertens I, Hubens G, Van Marck E, Pelckmans P et al. Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis. Eur J Gastroenterol Hepatol. 2010;22(12):1449-57.
  • 7. van der Graaff D, Kwanten WJ, Francque SM. The potential role of vascular alterations and subsequent impaired liver blood flow and hepatic hypoxia in the pathophysiology of non-alcoholic steatohepatitis. Med Hypotheses. 2019;122:188-97.
  • 8. Lautt WW. Regulatory processes interacting to maintain hepatic blood flow constancy: vascular compliance, hepatic arterial buffer response, hepatorenal reflex, liver regeneration, escape from vasoconstriction. Hepatol Res. 2007;37(11):891-903.
  • 9. Balasubramanian P, Boopathy V, Govindasamy E, Venkatesh BP. Assessment of portal venous and hepatic artery haemodynamic variation in non-alcoholic fatty liver disease (NAFLD) patients. J Clin Diagnostic Res. 2016;10(8):TC07.
  • 10. Soresi M, Giannitrapani L, Noto D, Terranova A, Campagna ME, Cefalù AB et al. Effects of steatosis on hepatic hemodynamics in patients with metabolic syndrome. Ultrasound Med Biol. 2015;41(6):1545-52.
  • 11. Hizli S, Koçyigit A, Arslan N, Tuncel SA, Demircioglu F, Cakmakçi H et al. Hepatic artery resistance in children with obesity and fatty liver. Indian J Pediatr. 2010;77(4):407-11.
  • 12. Mohammadi A, Ghasemi-Rad M, Zahedi H, Toldi G, Alinia T. Effect of severity of steatosis as assessed ultrasonographically on hepatic vascular indices in non-alcoholic fatty liver disease. Med Ultrason. 2011;13(3):200-6.
  • 13. Tarzamni MK, Khoshbaten M, Sadrarhami S, Daneshpajouhnejad P, Jalili J, Gholamian M et al. Hepatic artery and portal vein doppler indexes in non-alcoholic fatty liver disease before and after treatment to prevent unnecessary health care costs. Int J Prev Med. 2014;5(4):472-7.
  • 14. Ezaizi Y, Kabbany MN, Selvakumar PKC, Sarmini MT, Singh A, Lopez R et al. Comparison between non-alcoholic fatty liver disease screening guidelines in children and adolescents. JHEP Reports. 2019;1(4):259-64.
  • 15. Suri A, Song E, van Nispen J, Voigt M, Armstrong A, Murali V et al. Advances in the epidemiology, diagnosis, and management of pediatric fatty liver disease. Clin Ther. 2021;43(3):438-54.
  • 16. Tominaga K, Kurata JH, Chen YK, Fujimoto E, Miyagawa S, Abe I et al. Prevalence of fatty liver in Japanese children and relationship to obesity. Dig Dis Sci. 1995;40(9):2002-9.
  • 17. Schwimmer JB, Dunn W, Norman GJ, Pardee PE, Middleton MS, Kerkar N et al. SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease. Gastroenterology. 2010;138(4):1357-64,1364.e1-2.
  • 18. Fraser A, Longnecker MP, Lawlor DA. Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999–2004. Gastroenterology. 2007;133(6):1814-20.
  • 19. Ferraioli G, Wong VW-S, Castera L, Berzigotti A, Sporea I, Dietrich CF et al. Liver ultrasound elastography: an update to the world federation for ultrasound in medicine and biology guidelines and recommendations. Ultrasound Med Biol. 2018;44(12):2419-40.
  • 20. Choi SH, Kwon JH, Kim KW, Jang HY, Kim JH, Kwon H et al. Measurement of liver volumes by portal vein flow by Doppler ultrasound in living donor liver transplantation. Clin Transplant. 2017;31(9):e13050.
  • 21. Kim SH, Choi MS, Kim MJ, Kim YH, Cho SH. Role of semi–quantitative dynamic contrast–enhanced MR imaging in characterization and grading of prostate cancer. Eur J Radiol. 2017;94:154-9.
  • 22. Zhang L, Duan YY, Li JM, Yin JK. Hemodynamic features of Doppler ultrasonography in patients with portal hypertension: intraoperative direct measurement of portal pressure in the portal venous system. J Ultrasound Med. 2007;26(12):1689-96.
  • 23. Rocha HLOG, Diniz ALD, Borges VF de A e, Salomão FC. Assessment of portal venous index as a non-invasive method for diagnosing liver fibrosis in patients with chronic hepatitis C. Arq Gastroenterol. 2012;49(1):14-8.
  • 24. Belotta AF, Teixeira CR, Padovani CR, Rahal SC, Mayer MN, Mamprim MJ. Sonographic evaluation of liver hemodynamic indices in overweight and obese dogs. J Vet Intern Med. 2018;32(1):181-7.
  • 25. ML GDRM, Ferreira De Almeida EB V, Machado De Alcântara T, Borges De Araújo L, De Fátima Pinheiro C. Liver hemodynamic patterns in nonalcoholic steatosis: Doppler ultrasonography and histological evaluation. Minerva Gastroenterol Dietol. 2016;62(1):19-29.
  • 26. Singh SP, Barik RK. Noninvasive biomarkers in nonalcoholic fatty liver disease: Are we there yet? J Clin Exp Hepatol. 2020;10(1):88-98.
  • 27. Draijer LG, Feddouli S, Bohte AE, Rijcken THP, Benninga MA, Stoker J, et al. Comparison of diagnostic accuracy of screening tests ALT and ultrasound for pediatric non-alcoholic fatty liver disease. Eur J Pediatr. 2019;178(6):863-70.
  • 28. Tana C, Tana M, Rossi S, Silingardi M, Schiavone C. Hepatic artery resistive index (HARI) and non-alcoholic fatty liver disease (NAFLD) fibrosis score in NAFLD patients: cut-off suggestive of non-alcoholic steatohepatitis (NASH) evolution. J Ultrasound. 2016;9(3):183-9.
  • 29. Lim YS, Kim WR. The global impact of hepatic fibrosis and end-stage liver disease. Clin Liver Dis. 2008;12(4):733-46.
  • 30. Vos MB, Abrams SH, Barlow SE, Caprio S, Daniels SR, Kohli R et al. NASPGHAN clinical practice guideline for the diagnosis and treatment of nonalcoholic fatty liver disease in children: recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). J Pediatr Gastroenterol Nutr. 2017;64(2):319-34.
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 2148-9645
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1999
  • Yayıncı: KIRIKKALE ÜNİVERSİTESİ KÜTÜPHANE VE DOKÜMANTASYON BAŞKANLIĞI
Sayıdaki Diğer Makaleler

Acil Serviste Çocuklarda Düşme Olgularının Yönetimi: 261 Çocuk Olgunun Analizi

Mustafa ENES DEMİREL, Gulseren AKPİNAR

Semptomatik Safra Kesesi Taşı Hastalığında COVİD-19 Pandemisinin Etkisi

Serkan ŞENGÜL, Hasan ÇALIŞ, Yılmaz GÜLER, Zülfikar KARABULUT

İKİ FARKLI YOĞUN BAKIMDA KANDİDEMİ RİSK FAKTÖRLERİNİN DEĞERLENDİRİLMESİ

Dilek KOCABAŞ, Nurten Nur AYDIN, Firdevs AKSOY, Esra ÖZKAYA, Gürdal YILMAZ, İftihar KÖKSAL

Makrozomik Fetuslar 38. Gebelik Haftasında Doğurtulabilir Mi?

Mehmet AK, Emine AYDIN, Ayça Nazlı BULUT, Venhar CEYHAN, Mustafa Bertan DEMİR, Mehmet DOLANBAY

Asemptomatik Hipertansif Hastalarda Parçalanmış QRS Kompleksi ile Arteryel Komplians Arasındaki İlişki

Sinan ŞAHİN, Levent KORKMAZ, Ali Rıza AKYÜZ, Ömer Faruk ÇIRAKOĞLU, Ahmet ÖZDERYA, Selim KUL, Muhammet Raşit SAYIN

Travmatik Akut Subdural Hematom ve İnmelerde Dekompresif Kraniektomi Sonrası Kısa Dönem Prognoz ve Mortalite Riskinin Olası Belirteçleri

Bülent BAKAR, Mustafa ÖĞDEN, Süleyman AKKAYA, Bahar SAY, Alemiddin ÖZDEMİR, Ulaş YÜKSEL

METANOL ZEHİRLENMESİ NEDENİYLE ACİL SERVİSE BAŞVURAN HASTALARIN RETROSPEKTİF ANALİZİ

Oğuz EROĞLU, Ertan CÖMERTPAY, Turgut DENİZ

YÜZEYEL VARİSLERDE N-BUTİL SİYANOAKRİLAT İLE SKLEROTERAPİ SONUÇLARIMIZ

Ali BOLAT, Yıldırım GÜLTEKİN, Hüseyin GEMALMAZ

Non-Alkolik Yağlı Karaciğer Hastalığı Olan ve Olmayan Obez Çocuklarda Hepatik Vasküler Akım Değişikliklerinin Değerlendirilmesi

Hüseyin AYDIN, Ayşe AYDINOĞLU, Müge ATAR, Mustafa AKÇAM, Özgür PİRGON

TİROİD NODÜLÜ BULUNAN HASTALARDA SİSTEMİK İNFLAMASYON BELİRTEÇLERİNİN ROLÜ

Burak Mustafa TAŞ