Oğuz EROĞLU, Ertan CÖMERTPAY, Turgut DENİZ

METANOL ZEHİRLENMESİ NEDENİYLE ACİL SERVİSE BAŞVURAN HASTALARIN RETROSPEKTİF ANALİZİ

Amaç: Metanol zehirlenmesi ülkemizde son zamanlarda sıkça karşılaşılan bir zehirlenme türüdür. Zehirlenme durumunda vakaların hızla tanınıp tedavi altına alınması sayesinde mortalite ve morbidite oranları azaltılabilir. Bu çalışmanın amacı, acil servise başvuran metanol zehirlenmesi hastalarının demografik özellikleri, fizik muayene bulguları ve laboratuvar sonuçları ile sağ kalım arasındaki ilişkiyi araştırmaktır.

Anahtar Kelimeler:

Formik asit, Asit-Baz dengesi, Sağ kalım, Asidoz, Metanol

Retrospectıie Analysis of Patients Admıited to the Emergency Department Due to Methanol Poisoning

Objective: Methanol poisoning has become a frequently encountered type of poisoning in our country recently. In case of poisoning, mortality and morbidity rates can be reduced by rapidly recognizing and treating the cases. The aim of this study is to investigate the relationship between survival and the demographic characteristics, physical examination findings and laboratory results of methanol poisoning patients admitted to the emergency department.

Keywords:

Formic acid, Acid-Base balance, Survival, Acidosis, Methanol,

PDF

___

1. Satar S, Güneysel Ö, Türedi S, Yürümez Y, Akıcı A. Klinik Toksikoloji Tanı ve Tedavi. Alkoller ve Glikoller. Antalya. Çukurova Nobel Tıp Kitabevi, 2020.
2. Gulen M, Satar S, Avci A, Acehan S, Orhan U, Nazik H. Methanol poisoning in Turkey: Two outbreaks, a single center experience. Alcohol. 2020;88:83-90.
3. Rostrup M, Edwards JK, Abukalish M, Ezzabi M, Some D, Ritter H et al. The methanol poisoning outbreaks in Libya 2013 and Kenya 2014. PLoS One. 2016;11(3):e0152676.
4. Ashurst JV, Nappe TM. Methanol Toxicity. [Internet]. Treasure Island (FL). StatPearls Publishing, 2021.
5. Vural S. Transdermal methanol ıntoxication via folk medicine. J Emerg Med Case Rep. 2019;10(2):50-2.
6. Holt NR, Nickson CP. Severe methanol poisoning with neurological sequelae: implications for diagnosis and management. Intern Med J. 2018;48(3):335-9.
7. Beauchamp GA, Valento M, Kim J. Toxic alcohol ingestion: prompt recognition and management in the emergency department [digest]. Emerg Med Pract. 2016;18(9):S1-S2.
8. Roberts DM, Yates C, Megarbane B, Winchester JF, Maclaren R, Gosselin S et al. Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: A systematic review and consensus statement. Crit Care Med. 2015;43(2):461-72.
9. Sivilotti M, Sivilotti MLA, Burns MJ, Aaron CK, McMartin KE, Brent J. Reversal of severe methanol-induced visual impairment: No evidence of retinal toxicity due to fomepizole. J Toxicol - Clin Toxicol. 2001;39(6):627-31.
10. McMartin K, Jacobsen D, Hovda KE. Antidotes for poisoning by alcohols that form toxic metabolites. Br J Clin Pharmacol. 2016;81(3):505-15.
11. Barceloux DG, Krenzelok EP, Olson K, Watson W. American Academy of Clinical Toxicology Practice Guidelines on the treatment of ethylene glycol poisoning. Ad Hoc Committee. J Toxicol Clin Toxicol. 1999;37(5):537-60.
12. Hassanian-Moghaddam H, Nikfarjam A, Mirafzal A, Saberinia A, Nasehi AA, Masoumi Asl H et al. Methanol mass poisoning in Iran: Role of case finding in outbreak management. J Public Heal (U. Kingdom). 2015;37(2):354-9.
13. Schep LJ, Slaughter RJ, Vale JA, Beasley DMG. A seaman with blindness and confusion. BMJ. 2009;339:B3929.
14. Sözcü Gazetesi. Erişim tarihi: 20 Nisan 2021: https://www.sozcu.com.tr/2020/gundem/son-dakika-kirikkalede-sahte-ickiden-7-kisi-hayatini-kaybetti-6073679/
15. Evrensel Haber. Erişim tarihi: 20 Nisan 2021: https://www.evrensel.net/haber/416305/metil-alkol-zehirlenmesi-suphesiyle-15-gunde-73-kisi-yasamini-yitirdi
16. Anadolu Ajansı. Erişim tarihi: 20 Nisan 2021: https://www.aa.com.tr/tr/turkiye/metil-alkol-zehirlenmesi-nedeniyle-15-gunde-71-kisi-oldu/2016389
17. Paasma R, Hovda KE, Hassanian-Moghaddam H, Brahmi N, Afshari R, Sandvik L et al. Risk factors related to poor outcome after methanol poisoning and the relation between outcome and antidotes a multicenter study. Clin Toxicol. 2012;50(9):823-31.
18. Resmî Gazete. Erişim tarihi: 20 Nisan 2021: https://www.resmigazete.gov.tr/eskiler/2019/01/20190109.pdf
19. Hovda KE, Hunderi OH, Tafjord AB, Dunlop O, Rudberg N, Jacobsen D. Methanol outbreak in Norway 2002-2004: Epidemiology, clinical features and prognostic signs. J Internal Med. 2005;258(2):181-90.
20. Zakharov S, Pelclova D, Urban P, Navratil T, Diblik P, Kuthan P et al. Czech mass methanol outbreak 2012: Epidemiology, challenges and clinical features Clinical Toxicology. 2014;52(10):1013-24.
21. Massoumi G, Saberi K, Eizadi-Mood N, Shamsi M, Alavi M, Morteza A. Methanol poisoning in Iran, from 2000 to 2009. Drug Chem Toxicol. 2012;35(3):330-3.
22. Ahmed F, Khan NU, Ali N, Feroze A. Methanol poisoning: 27 years experience at a tertiary care hospital. J Pak Med Assoc. 2017;67(11):1751-2.
23. Callaghan M. A drink to die for: Arak and methanol poisoning in Indonesia. Travel Med Infect Dis. 2015;13(6):507-8.
24. Zyoud SH, Al-Jabi SW, Sweileh WM, Awang R, Waring WS. Bibliometric profile of the global scientific research on methanol poisoning (1902-2012). J Occup Med Toxicol. 2015;10:17.
25. Yayci N, Ağritmiş H, Turla A, Koç S. Fatalities due to methyl alcohol intoxication in Turkey: an 8-year study. Forensic Sci Int. 2003;131(1):36-41.
26. Celik S, Karapirli M, Kandemir E, Ucar F, Kantarci MN, Gurler M et al. Fatal ethyl and methyl alcohol-related poisoning in Ankara: A retrospective analysis of 10,720 cases between 2001 and 2011. J Forensic Leg Med. 2013;20(3):151-4.
27. Paasma R, Hovda KE, Tikkerberi A, Jacobsen D. Methanol mass poisoning in Estonia: outbreak in 154 patients. Clin Toxicol (Phila). 2007;45(2):152-7.
28. Liu JJ, Daya MR, Carrasquillo O, Kales SN. Prognostic factors in patients with methanol poisoning. J Toxicol Clin Toxicol. 1998;36(3):175-8.