AĞIR HİPOTİROİDİZMLİ HASTALARDA KARDİYOVASKÜLER HASTALIK RİSKİNİN DEĞERLENDİRİLMESİNDEPLAZMA ATEROJENİK İNDEKS, CASTELLİ RİSK İNDEKSİ VE ATEROJENİK KATSAYI

Amaç: Aşikâr hipotiroidide lipid metabolizması değişimine bağlı dislipidemi oluşmaktadır. Lipid metabolizmasındaki değişikliklerin aterojenik değişiklikleri arttırabileceğini düşünmekteyiz. Literatürde ağır hipotiroidi ile ilgili aterojenite çalışmalarının çok nadir olması nedeniyle çalışmamızda ağır hipotiroidili hastalarda aterojenite ile ilişkili indeksleri değerlendirdik.Gereç ve Yöntemler: Retrospektif kesitsel çalışmamıza, 50 ağır hipotiroidili ve 50 sağlıklı kontrol olmak üzere yüz hasta dahil edildi. Trigliserid glukoz indeksi, Trigliserid glukoz- vücut kitle indeksi, plazma aterojenik indeksi, Castelli risk indeksi ve aterojenik katsayı gibi aterojenik indeksler, lipid profili verileri kullanılarak hesaplandı.Bulgular: Ağır hipotiroidi grubunun yaş ortalaması 47.1±16.6 yıl ve kontrol grubunun yaş ortalaması 49.4±6.4 yıl olarak saptandı. Geleneksel lipid parametrelerinden total kolesterol, trigliserid, düşük yoğunluklu lipoprotein, yüksek yoğunluklu lipoprotein dışı kolesterol düzeyleri ağır hipotiroidi grubunda anlamlı olarak yüksekti (p

Atherogenic Index of Plasma, Castelli Risk Index and Atherogenic Coefficient in the Assessment of Cardiovascular Disease Risk in Patients with Severe Hypothyroidism

Objective: In overt hypothyroidism, dyslipidemia occurs due to lipid metabolism changes. We think that changes in lipid metabolism may increase atherogenic changes. Since atherogenicity studies related to severe hypothyroidism are very rare in the literature, we evaluated atherogenicity-related indices in patients with severe hypothyroidism in our study.Material and Methods: Our retrospective cross-sectional study included 100 subjects, 50 with severe hypothyroidism and 50 healthy controls. Triglyceride glucose index, triglyceride-glucose-body mass index and atherogenic indices such as the Castelli’s Risk Index (CRI), atherogenic index of plasma and atherogenic coefficient were calculated using lipid profile data. Statistical analysis was performed by comparing the lipid profile and atherogenic indexes.Results: The mean age of the severe hypothyroidism group was 47.1±16.6 and the mean age of the control group was 49.4±6.4 years. In traditional lipid parameters, total cholesterol, triglyceride, low-density lipoprotein, non-high density lipoprotein cholesterol levels were significantly higher in the severe hypothyroidism group (p

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