İNHALER İLAÇ KULLANIMINA BAĞLI ORAL YAN ETKİLER: DOĞRU BİLİNEN BİR YANLIŞ MI?

Amaç: Kronik solunum yolu hastalıklarında, oral ve dental sorunlar önemli bir komorbidite nedeni olarak görülmektedir. Oral ve dental sorunların en önemli nedeni olarak yaygın görüş ise inhaler ilaçlardır. Bu görüş hastaların ilaçları uygun süre, dozda almamalarına ve tedavinin tam sağlanamamasına neden olmaktadır. Bu nedenle, çalışmamızın amacı, kronik solunumsal hastalığı nedeniyle inhaler ilaçlar kullanan hastalarda, oral-orofarengeal, dental bulguları değerlendirmek ve ilaç kullanım uyumunu artırmayı sağlayabilmektir.

Anahtar Kelimeler:

İnhaler tedavi, inhaler ilaçlar, oral hijyen, oro-dental bulgular

Oral Side Effects Related to Inhaler Medication Use: Is It a Well-known Mistake?

Objective: Oral and dental problems are considered as an important cause of comorbidity in chronic respiratory diseases. The common opinion regards inhalers as the most important cause of oral and dental problems. This opinion causes patients not to take the drugs in the appropriate time and dose thus the treatment is not fully provided. The aim of our study is to evaluate oral-oropharyngeal and dental findings and to increase drug use compliance in patients using inhaler drugs due to chronic respiratory disease.

Keywords:

Choronıc respiratory diseases, inhaler therapy, oral hygine, oro-dental findings,

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1. Yaghobee S, Paknejad M, Khorsand A. Association between asthma and periodontal disease. Frontiers in Dentistry. 2008;5(2):47-51.
2. Janson C, Chinn S, Jarvis D, Burney P. Physician-diagnosed asthma and drug utilization in the European Community Respiratory Health Survey. Eur Respir J. 1997;10(8):1795-802.
3. GINA 2019: a fundamental change in asthma management. Updated 2019: https://ginasthma.org/gina-2019-a-fundamental-change-in-asthma-management/
4. Hobbins S, Chapple IL, Sapey E, Stockley RA. Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors? Int J Chron Obstruct Pulmon Dis. 2017;12(5):1339-49.
5. Lopez-de-Andrés A, Vazquez-Vazquez L, Martinez-Huedo MA, Hernández-Barrera V, Jimenez-Trujillo I, Tapias-Ledesma MA et al. Is COPD associated with periodontal disease? A population-based study in Spain. Int J Chron Obstruct Pulmon Dis. 2018;13(1):3435-45.
6. Baldomero AK, Siddiqui M, Lo CY, Petersen A, Pragman AA, Connett JE et al. The relationship between oral health and COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2019;14(4):881-92.
7. Global Strategy for the Diagnosis, Management and Prevention of Choronic Obstructive Pulmonary Diseases, 2020 Report. Accessed: www.goldcopd.com.
8. Astım Tanı ve Tedavi Rehberi 2020 Güncellemesi. Türkiye Ulusal Allerji ve Klinik İmmünoloji Derneği ve Türk Toraks Derneği. Erişim: https://www.toraks.org.tr/site/news/10122, https://www.aid.org.tr/wp-content/uploads/2020/12/astim-rehberi-2020.pdf
9. Gaeckle NT, Heyman B, Criner AJ, Criner GJ. Markers of dental health correlate with daily respiratory symptoms in COPD. Chronic Obstr Pulm Dis. 2018;5(2):97-105.
10. Bergström J, Cederlund K, Dahlén B, Lantz AS, Skedinger M, Palmberg L et al. Dental health in smokers with and without COPD. PLoS One. 2013;8(3):e59492.
11. Dwibedi N, Wiener RC, Findley PA, Shen C, Sambamoorthi U. Asthma, chronic obstructive pulmonary disease, tooth loss, and edentulism among adults in the United States: 2016 Behavioral Risk Factor Surveillance System Survey. J Am Dent Assoc. 2020;151(10):735-744.e1.
12. Devlin J. Patients with chronic obstructive pulmonary disease: management considerations for the dental team. Br Dent J. 2014;217(5):235-7.
13. Vucicevic Boras V, Savage N, Mohamad Zaini Z. Oral aphthous-like ulceration due to tiotropium bromide. Med Oral Patol Oral Cir Bucal. 2007;12(3):E209-10.
14. Aral K, Aral CA, Kalkan RE. Astım ve ağız sağlığı. EÜ Dişhek Fak Derg. 2016;37(2):42-6.
15. Thomas MS, Parolia A, Kundabala M, Vikram M. Asthma and oral health: a review. Aust Dent J. 2010;55(2):128-33.
16. Wu FY, Liu JF. Asthma medication increases dental caries among children in Taiwan: An analysis using the National Health Insurance Research Database. J Dent Sci. 2019;14(4):413-8.
17. Chumpitaz-Cerrate V, Bellido-Meza JA, Chávez-Rimache L, Rodríguez-Vargas C. Impact of inhaler use on dental caries in asthma pediatrics patients: A case-control study. Arch Argent Pediatr. 2020;118(1):38-46.
18. Erdoğan T, Karakaya G, Kalyoncu AF. The frequency and risk factors for oropharyngeal candidiasis in adult asthma patients using ınhaled corticosteroids. Turk Thorac J. 2019;20(2):136-9.
19. Ho SW, Lue KH, Ku MS. Allergic rhinitis, rather than asthma, might be associated with dental caries, periodontitis, and other oral diseases in adults. PeerJ. 2019;7:e7643.