HİPERTANSİF SOL VENTRİKÜL HİPERTROFİSİNİN VENTRİKÜLER REPOLARİZASYON ÜZERİNE ETKİSİ

Amaç: T dalgasının tepe ve sonu aralığı (Tp-e), Tp-e/QT oranı ve Tp-e/QTc oranı ventriküler repolarizasyonun yeni indeksleridir ve ventriküler aritmiler ile ilişkilendirilmiştir. Hem hipertansiyon hem de sol ventriküler hipertrofi varlığının ventriküler aritmi gelişimi ve ani kardiyak ölüm için bir risk faktörü olduğu bilinmektedir. Bu çalışmada, hipertansiyon hastalarında sol ventriküler hipertrofi varlığının Tp-e aralığı, Tp-e/QT oranı ve Tp-e/QTc oranı üzerindeki etkisini belirlemeyi hedefledik.

The Effect of Hypertensive Left Ventricular Hypertrophy on Ventricular Repolarization

Objective: The peak and end interval of the T wave (Tp-e), the Tp-e/QT ratio and the Tp-e/QTc ratio are new indices of ventricular repolarization and have been associated with ventricular arrhythmias. It is known that the presence of both hypertension and left ventricular hypertrophy is a risk factor for the development of ventricular arrhythmia and sudden cardiac death. In this study, we aimed to determine the effect of the presence of left ventricular hypertrophy on Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with hypertension.

___

  • 1. Dahlöf B, Devereux R, de Faire U, Fyhrquist F, Hedner T, Ibsen H et al. The Losartan Intervention for Endpoint reduction (LIFE) in hypertension study: rationale, design, and methods. The LIFE Study Group. Am J Hypertens. 1997;10(7 Pt 1):705-13.
  • 2. Dahlöf B, Devereux RB, Julius S, Kjeldsen SE, Beevers G, de Faire U et al. Characteristics of 9194 patients with left ventricular hypertrophy: the LIFE study. Losartan intervention for endpoint reduction in hypertension. Hypertension. 1998;32(6):989-97.
  • 3. Passino C, Magagna A, Conforti F, Buralli S, Kozáková M, Palombo C et al. Ventricular repolarization is prolonged in nondipper hypertensive patients: role of left ventricular hypertrophy and autonomic dysfunction. J Hypertens. 2003;21(2):445-51.
  • 4. Antzelevitch C, Shimizu W, Yan GX, Sicouri S. Cellular basis for QT dispersion. J Electrocardiol. 1998;30 Suppl:168-75.
  • 5. de Bruyne MC, Hoes AW, Kors JA, Hofman A, van Bemmel JH, Grobbee DE. QTc dispersion predicts cardiac mortality in the elderly: the Rotterdam Study. Circulation. 1998;97(5):467-72.
  • 6. Kors JA, Ritsema van Eck HJ, van Herpen G. The meaning of the Tp-Te interval and its diagnostic value. J Electrocardiol. 2008;41(6):575-80.
  • 7. Antzelevitch C, Sicouri S, Di Diego JM, Burashnikov A, Viskin S, Shimizu W et al. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart Rhythm. 2007;4(8):1114-9.
  • 8. Gupta P, Patel C, Patel H, Narayanaswamy S, Malhotra B, Green JT et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol. 2008;41(6):567-74.
  • 9. Zhao X, Xie Z, Chu Y, Yang L, Xu W, Yang X et al. Association between Tp-e/QT ratio and prognosis in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Clin Cardiol. 2012;35(9):559-64.
  • 10. Luo X, Lin H, Pan Z, Xiao J, Zhang Y, Lu Y et al. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J Biol Chem. 2008;283(29):20045-52.
  • 11. Marionneau C, Brunet S, Flagg TP, Pilgram TK, Demolombe S, Nerbonne JM. Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy. Circ Res. 2008;102(11):1406-15.
  • 12. Wang JF, Shan QJ, Yang B, Chen ML, Zou JG, Xu DJ et al. Tpeak-Tend interval as a new risk factor for arrhythmic event in patient with Brugada syndrome. JNMU. 2007;21(4):213-7.
  • 13. Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation. 1998;98(18):1928-36.
  • 14. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560-72.
  • 15. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57(6):450-8.
  • 16. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28(1):1-39.e14.
  • 17. Bazett HC. An analysis of the time-relations of electrocardiograms. Heart.1920;(7):353-70.
  • 18. Guo D, Young L, Patel C, Jiao Z, Wu Y, Liu T et al. Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit. Am J Physiol Heart Circ Physiol. 2008;295(1):H97-H104.
  • 19. Salles GF, Cardoso CR, Leocadio SM, Muxfeldt ES. Recent ventricular repolarization markers in resistant hypertension: are they different from the traditional QT interval? Am J Hypertens. 2008;21(1):47-53.
  • 20. Hlaing T, Guo D, Zhao X, DiMino T, Greenspon L, Kowey PR et al. The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension. J Electrocardiol. 2005;38(4 Suppl):154-8.
  • 21. Watanabe N, Kobayashi Y, Tanno K, Miyoshi F, Asano T, Kawamura M et al. Transmural dispersion of repolarization and ventricular tachyarrhythmias. J Electrocardiol. 2004;37(3):191-200.
  • 22. Day CP, McComb JM, Campbell RW. QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br Heart J. 1990;63(6):342-4.
  • 23. Saenen JB, Vrints CJ. Molecular aspects of the congenital and acquired Long QT Syndrome: clinical implications. J Mol Cell Cardiol. 2008;44(4):633-46.
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 2148-9645
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1999
  • Yayıncı: KIRIKKALE ÜNİVERSİTESİ KÜTÜPHANE VE DOKÜMANTASYON BAŞKANLIĞI
Sayıdaki Diğer Makaleler

Özel Hastaneye Başvuran Hastalarda Vajinit Etkenlerinin Üç Yıllık Retrospektif Analizi

Özge ÜNLÜ, Tülay ÇAĞLAR, Mustafa Genco ERDEM, Seda EKİCİ, Mehmet DEMİRCİ

Sağ Ventriküler Deformasyon Analizi İçin Transözofageal ve Transtorasik Ekokardiyografinin Karşılaştırmalı Değerlendirmesi

Pınar DEMİR GÜNDOĞMUŞ, Kamuran KALKAN, Uğur AKSU, Emrah AKSAKAL, Oğuzhan BİRDAL

Odontojenik Keratokistlerin Klinikopatolojik Analizi: Tek Merkezden 10 Yıllık Deneyim

Fatih YILMAZ, Ömür DERECİ, Nesrin SARUHAN, Fuat AÇIKALIN

Derin Boyun Enfeksiyonunda Prognostik Faktörler

Ela CÖMERT, Buğra ŞİMŞEK

ULNAR SİNİR YARALANMALARINDA STİMÜLASYON: OLGU SUNUMU

Nazife KAPAN, Merve KAPAN, Busenur KARMIŞ, Müyesser ARAS, Bedriye BAŞKAN

ÇOCUKLARDA AKUT APANDİSİT TANISINDA ALVARADO SKORU İLE ULTRASONOGRAFİ BULGULARI, LABORATUVAR PARAMETRELERİ, CRP / ALBÜMİN ORANI VE TROMBOSİT KİTLE İNDEKSİNİN KORELASYONUNUN DEĞERLENDİRİLMESİ

Ramazan DULKADİR, Ülgen ÇELTİK, Zeliha GUZELKUCUK

İNHALER İLAÇ KULLANIMINA BAĞLI ORAL YAN ETKİLER: DOĞRU BİLİNEN BİR YANLIŞ MI?

Duygu ZORLU, Mehmet SAYLAM

Adölesan Serebral Palsili Bireylerde Fiziksel Aktivite ve Fiziksel Uygunluk Seviyelerinin Değerlendirilmesi

Hanifi EROL, Meral SERTEL, Ayşegül ALPCAN, Mutluay ARSLAN

SPORCULARDA KULLANILAN MANUEL TERAPİ TEKNİKLERİNİN PERFORMANS VE TOPARLANMA ÜZERİNE ETKİLERİNİN İNCELENMESİ: SİSTEMATİK DERLEME

Erkan ÖZYILMAZ, Ömer ŞENEL, Rabia Tuğba KILIÇ, Emre UYSAL, Abdullah Yener İNCE

Obez Tip 2 Diyabetik Hastalarda Eksenatid Tedavisinin Metabolik Parametreler, Ghrelin, GDF-15 ve FGF-21 Üzerine Etkileri

Müge ÖZSAN YILMAZ, Oğuzhan ÖZCAN