Obez Tip 2 Diyabetik Hastalarda Eksenatid Tedavisinin Metabolik Parametreler, Ghrelin, GDF-15 ve FGF-21 Üzerine Etkileri

Amaç: Glukagon Benzeri Peptid-1(GLP-1) benzeri etkileri olan eksenatid ve benzeri ilaçlar son yıllarda diyabet ve obezite tedavisinde sıklıkla kullanılmaktadır. Bu çalışmada eksenatidin iştah ve metabolik bozukluklarla ilişkili olduğu bilinen hormonal özellikli peptidler olan ghrelin, FGF-21 ve GDF-15 üzerine etkilerini araştırmayı amaçladık.

Anahtar Kelimeler:

obezite, eksenatid, ghrelin, Fibroblast Büyüme Faktörü 21, Büyüme Farklılaşma Faktörü 15

THE EFFECTS OF EXENATIDE TREATMENT ON METABOLIC PARAMETERS, GHRELIN, GDF-15 AND FGF-21 IN OBESE TYPE 2 DIABETIC PATIENTS

Objective: Exenatide and similar drugs which have Glucagon Like Peptide-1(GLP-1) like effects have been used frequently in the treatment of diabetes and obesity in recent years. In this study we aimed to investigate the effects of exenatide on ghrelin, FGF-21 and GDF-15 which are known to be associated with appetite and metabolic disorders.

Keywords:

obesity, exenatide, ghrelin, Fibroblast Growth Factor 21, Growth Differentiation Factor 15,

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