Renal Hücreli Karsinomda Prognostik Belirteçler Olarak CD44 ve Ki-67 Birlikteliği

Amaç: Renal hücreli karsinomun (RHK) önemli bir özelliği değişen prognozudur. Son yıllarda, birkaç potansiyel biyobelirteç araştırılmış olup ve bu umut verici biyobelirteçlere ait doğrulayıcı çalışmalar klinik uygulamayı geliştirmek için gereklidir. Bu çalışmada, berrak hücreli RHK'de CD44 ekspresyonunun prognostik öneminin, Ki-67 ve p53 ile karşılaştırarak araştırılması amaçlandı.

Anahtar Kelimeler:

Renal hücreli karsinom, berrak hücreli, CD44, Ki-67, p53, p53

COEXISTENCE OF CD44 AND KI-67 AS THE PROGNOSTIC MARKERS IN RENAL CELL CARCINOMA

Objective: An important feature of renal cell carcinoma (RCC) is its changeable prognosis. In recent years, several potential biomarkers have been investigated and confirmatory studies of these promising biomarkers are necessary to improve the clinical practice. In the present study, it was aimed to investigate the prognostic significance of CD44 expression by comparing it with Ki-67 and p53 in clear cell RCC.

Keywords:

Renal cell carcinoma, clear cell, CD44, Ki-67, p53,

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