AKUT KORONER SENDROMDA SERUM FİBRİNOJEN DÜZEYİ İLE STENT RESTENOZU ARASINDAKİ İLİŞKİ

Amaç: İn-stent restenoz, koroner arterlere stent implantasyonu sonrası stentli bölgenin aşamalı olarak yeniden daralmasıdır. İlaç salınımlı stentlerin kullanılmaya başlanmasıyla restenoz oranları azalmış olsa da hala majör problem olmaya devam etmektedir. Bu çalışmada akut koroner sendrom nedeniyle koroner anjiyografi yapılan hastalarda in-stent restenozu ile fibrinojen düzeyi arasındaki ilişkiyi araştırmayı amaçladık.

The Relationship Between Serum Fibrinogen Level and Stent Restenosis in Patients with Acute Coronary Syndrome

Objective: In-stent restenosis (ISR) is a gradual re-constriction of the stented area after stent implantation in the coronary arteries. Although the rate of re-stenosis was decreased after using drug-induced stents, it still remains as a major problem. In this study, we aimed to investigate the relationship between ISR and fibrinogen levels in patients undergoing coronary angiography for acute coronary syndrome.

___

  • 1. Mann DL, Zipes DP, Libby P, Braunwald E, Bonow RO. Braunwald's heart disease: a textbook of cardiovascular medicine. 10th ed. Philadelphia. Elsevier, Saunders, 2015.
  • 2. Rajagopal V, Rockson SG. Coronary restenosis: a review of mechanisms and management. Am J Med. 2003;115(7):547-53.
  • 3. Lowe HC, Oesterle SN, Khachigian LM. Coronary instent restenosis: current status and future strategies. J Am Coll Cardiol. 2002;39(2):183-93.
  • 4. Farb A, Sangiorgi G, Carter AJ, Walley VM, Edwards WD, Schwartz RS et al. Pathology of acute and chronic coronary stenting in humans. Circulation. 1999;99(1):44-52.
  • 5. Smith EB, Thompson WD, Crosbie L, Stirk CM. Fibrinogen/fibrin in atherogenesis. Eur J Epidemiol. 1992;8(Suppl 1):83-7.
  • 6. Ang L, Behnamfar O, Palakodeti S, Lin F, Pourdjabbar A, Patel MP et al. Elevated baseline serum fibrinogen: effect on 2-year major adverse cardiovascular events following percutaneous coronary intervention. J Am Heart Assoc. 2017;6(11):e006580.
  • 7. Mahmud E, Ramsis M, Behnamfar O, Enright K, Huynh A, Kaushal K et al. Effect of serum fibrinogen, total stent length, and type of acute coronary syndrome on 6-month major adverse cardiovascular events and bleeding after percutaneous coronary intervention. Am J Cardiol. 2016;117(10):1575-81.
  • 8. Wilhelmsen L, Svardsudd K, Korsan-Bengtsen K, Larsson B, Welin L, Tibblin G. Fibrinogen as risk factor for stroke and myocardial infarction. N Engl J Med. 1984;311(8):501-5.
  • 9. Toss H, Lindahl B, Siegbahn A, Wallentin L. Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease. Circulation. 1997;96(12):4204-10.
  • 10. Folsom AR, Wu KK, Rosamond WD, Sharrett AR, Chambless LE. Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 1997;96(4):1102-8.
  • 11. Otsuka M, Hayashi Y, Ueda H, Imazu M, Kohno N. Predictive value of preprocedural fibrinogen concerning coronary stenting. Atherosclerosis. 2002;164(2):371-8.
  • 12. Lupi A, Secco GG, Rognoni A, Rossi L, Lazzero M, Nardi F. Plasma fibrinogen levels and restenosis after primary percutaneous coronary intervention. J Thromb Thrombolysis. 2012;33(4):308-17.
  • 13. Jukema JW, Verschuren JJ, Ahmed TA, Quax PH. Restenosis after PCI. Part 1: pathophysiology and risk factors. Nat Rev Cardiol. 2011;9(1):53-62.
  • 14. Naito M, Stirk C, Smith E, Thompson W. Smooth muscle cell outgrowth stimulated by fibrin degradation products. The potential role of fibrin E in restenosis and atherogenesis. Thromb Res. 2000;98(2):165-74.
  • 15. Yarnell JWG, Baker IA, Sweetnam PM, Bainton D, O’Brien JR, Whitehead PJ et al. Fibrinogen, viscosity and White blood cell count are major risk factors for ischemic heart disease: the Caerphilly and Speedwell collaborative heart disease studies. Circulation. 1991;83(3):836-44.
  • 16. Collaborative metaanalysis of prospective studies of plasma fibrinogen and cardiovascular disease. Eur J Cardiovasc Prev Rehabil. 2004;11(1):9-17.
  • 17. Handa K, Kono S, Saku K, Sasaki J, Kawano T, Sasaki Y et al. Plasma fibrinogen levels as an independent indicator of severity of coronary atherosclerosis. Atherosclerosis. 1989;77(2-3):209-13.
  • 18. Broadhurst P, Kelleher C, Hughes L, Imeson JD, Raftery EB. Fibrinogen, factor VII clotting activity and coronary artery disease severity. Atherosclerosis.1990;85(2-3):169-73.
  • 19. Schumacher M, Eber B, Tiran A, Toplak H, Luha O, Gasser R et al. Fibrinogen values in patients with and without restenosis following percutaneous transluminal coronary angioplasty. Cardiology. 1992;80(5-6):345-8.
  • 20. Rahel M, Visseren FLJ, Suttorp MJ, Plokker THW, Kelder JC, de Jongh BM et al. Preprocedural serum levels of acute-phase reactants and prognosis after percutaneous coronary intervention. Cardiovasc Res. 2003;60(1):136-40.
  • 21. Assadpour Piranfar M. The Correlation between high-sensitivity c-reactive protein (HSCRP) serum levels and severity of coronary atherosclerosis. Int Cardiovasc Res J. 2014;8(1):6-8.
  • 22. Koenig W. High-sensitivity C-reactive protein and atherosclerotic disease: from improved risk prediction to risk-guided therapy. Int J Cardiol. 2013;168(6):5126-34.
  • 23. Baktashian M, Saffar Soflaei S, Kosari N, Salehi M, Khosravi A, Ahmadinejad M et al. Association of high level of hs-CRP with in-stent restenosis: A case-control study. Cardiovasc Revasc Med. 2019;20(7):583-7.
  • 24. Yeter E, Aygül N, Kayrak M, Tokaç M, Gök H. Revaskülarizasyon sonrası restenozun efor testi ile değerlendirilmesi ve restenoz için bir risk olarak fibrinojen ve C-reaktif proteinin değeri. Genel Tıp Derg. 2005;15(3):111-5.
  • 25. Hong SJ, Kim MH, Ahn TH, Ahn YK, Bae JH, Shim WJ et al. Multiple predictors of coronary restenosis after drug-eluting stent implantation in patients with diabetes. Heart. 2006;92(8):1119- 24.
  • 26. Hu RT, Liu J, Zhou Y, Hu BL. Association of smoking with restenosis and major adverse cardiac events after coronary stenting: A meta-analysis. Pak J Med Sci. 2015;31(4):1002-8.
  • 27. Tocci G, Barbato E, Coluccia R, Modestino A, Pagliaro B, Mastromarino V et al. Blood pressure levels at the time of percutaneous coronary revascularization and risk of coronary ın-stent restenosis. Am J Hypertens. 2016;29(4):509-18.
  • 28. Veinot JP, Edwards WD, Camrud AR, Jorgenson MA, Holmes DR Jr, Schwartz RS. The effects of lovastatin on neointimal hyperplasia following injury in a porcine coronary artery model. Can J Cardiol. 1996;12(1):65-70.
  • 29. Bertrand ME, McFadden EP, Fruchart JC, Van Belle E, Commeau P, Grollier G et al. Effect of pravastatin on angiographic restenosis after coronary balloon angioplasty. The PREDICT Trial Investigators. Prevention of restenosis by elisor after transluminal coronary angioplasty. J Am Coll Cardiol. 1997;30(4):863-9.
  • 30. Weintraub WS, Boccuzzi SJ, Klein JL, Kosinski AS, King SB 3rd, Ivanhoe R et al. Lack of effect of lovastatin on restenosis after coronary angioplasty. Lovastatin Restenosis Trial Study Group. N Engl J Med. 1994;331(20):1331-7.
  • 31. Violaris AG, Melkert R, Serruys PW. Influence of serum cholesterol and cholesterol subfractions on restenosis after successful coronary angioplasty. A quantitative angiographic analysis of 3336 lesions. Circulation. 1994;90(5):2267-79.
  • 32. Luca GD, Suryapranata H, Gregorio G, Lange H, Chiariello M. Homocysteine and its effects on in-stent restenosis. Circulation. 2005;112(19):307-11.
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 2148-9645
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1999
  • Yayıncı: KIRIKKALE ÜNİVERSİTESİ KÜTÜPHANE VE DOKÜMANTASYON BAŞKANLIĞI
Sayıdaki Diğer Makaleler

Kuru Kafalarda Processus Mastoideus Morfometrisi

Selma ÇALIŞKAN, Sinem AKKAŞOĞLU, Mustafa Fevzi SARGON, Deniz DEMİRYÜREK

Nöral Tüp Defektlerinde Duyarlılık Oluşturan Risk Faktörleri Olarak Faktör V ve MTHFR Genlerinin Analizi: Türkiye'den Bir Vaka-Kontrol Çalışması

İbrahim Halil YILDIRIM, Kağan KAMAŞAK, Zeynep YEĞİN

ÇOCUKLARDA KRONİK KARACİĞER HASTALIKLARINA YAKLAŞIM

Burcu GÜVEN

Akromegali: MRG Bulguları ile Birlikte Bir Olgu Sunumu

Şule ERDEM, Şuheda ERDEM, Kaan GÜNDÜZ

Nöral Tüp Defektlerinde Duyarlılık Oluşturan Risk Faktörleri Olarak Faktör V ve MTHFR Genlerinin Analizi: Türkiye'den Bir Vaka-Kontrol Çalışması

Kağan KAMAŞAK, Zeynep YEĞİN, İBRAHİM HALİL YILDIRIM

Kardiyopulmoner Resüsitasyon Sonrası Dolaşımın Sağlandığı Hastalarda Gelişen Toraks Yaralanmaların Toraks BT ile Değerlendirilmesi

Süleyman ERSOY, Yeliz DADALI, Burak ÇELİK, Hacı Mehmet ÇALIŞKAN

Drenden Ölçülen Amilaz Değerleri Acil Splenektomi Sonrası İyatrojenik Pankreas Yaralanmasına Sekonder Pankreatik Fistül Gelişimini Öngörmede Faydalı mıdır?

Alp YILDIZ, Aybala YILDIZ

Baş ve Boyun Radyoterapisinin Tiroid Volümü ve Fonksiyonu Üzerine Akut Etkileri Üzerine Kesitsel Bir Çalışma

Fevziye İlknur KAYALI, Uğur TOPRAK, Rahşan HABİBOĞLU

AMELOBLASTOMA VE ODONTOJENİK KERATOKİSTLERİN KLİNİK VE RADYOLOJİK DAVRANIŞI: VAKA SERİLERİYLE BİRLİKTE LİTERATÜR TARTIŞMASI

Melda MISIRLIOĞLU, Zahide MEŞHUR, Yağmur YILMAZ AKYIL

Preoperatif Stent Uygulamasının Retrograd İntrarenal Cerrahi Sonuçları Üzerine Etkisi

Mehmet CANİKLİOĞLU, Ünal ÖZTEKİN, Sercan SARI, Volkan SELMİ, Abdullah GÜREL, Levent IŞIKAY, Fatih ATAÇ