Nevzat KONAR, Ender Sinan POYRAZOĞLU, Köksal DEMİR, Iraz HASPOLAT, Nevzat ARTIK

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Fitoöstrojenler: Bitkisel Kaynaklı Östrojenik Bileşikler

Östrojen, yumurtalık ve testislerde üretilen ancak üreme sisteminin yanı sıra pek çok biyolojik etkiye sahip olan bir hormondur. Fitoöstrojenler ise çeşitli yenilebilir bitkinin yapısında, farklı düzey ve kompozisyonlarda yer alan, östrojenlere benzer yapı ve aktivitelere sahip bileşiklerdir. 20. Yüzyılın ilk çeyreği sonrasında yonca ile beslenen hayvanların bazılarında görülen infertilite ile ilişkilendirilerek dikkat çeken bu bileşiklerin son 30 yıl içerisinde insan kaynaklı biyolojik örneklerde tanımlanmasına ve sağlık üzerinde çeşitli etkilerinin incelenmesine başlanmıştır. Bitkilerde özellikle antioksidan rolü üstlenmiş olan bu maddeler, hayvanlarda ve insanlarda ise östrojen agonist ve antagonistleri olarak aktivite sahibidirler. Kimyasal yapıları esas alındıklarında özellikle isoflavon ve lignan grupları altında toplanabilmekte olup, komestan ve stilben grubu üyelerinin bazıları da fitoöstrojenik madde olarak tanımlanmaktadırlar
Anahtar Kelimeler:

Fitoöstrojen, Fenolik bileşikler, Östrojen, Isoflavon, Lignan

Phytoestrogens: Plant-derived Estrogenic Compounds

Estrogen is a hormone, which is produced in ovary and testis; however, it has many biological effects besides the reproductive system. Phytoestrogens are the compounds, which have estrogen-like structure and activities, taking place in structure of various edible plants at different levels and in different compositions. These compounds attracted notice after the first quarter of 20th century upon they had been associated with infertility seen in some of animals fed with alfalfa, and these compounds have been identified in human-derived biological samples and its effects on health have been taken under study in the recent 30 years. These materials have especially antioxidant role in plants while they have activities in animals and humans as estrogen agonist and antagonists. Based on their chemical structure, they may be gathered under especially isoflavon and lignan groups while some of members of coumestan and stilbene groups are also identified as phytoestrogenic compound.
Keywords:

Phytoestrogen, Phenolic Compounds, Estrogen, Isoflavone, Lignan,

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Karaelmas Fen ve Mühendislik Dergisi-Cover
  • ISSN: 2146-4987
  • Yayın Aralığı: Yılda 2 Sayı
  • Başlangıç: 2011
  • Yayıncı: ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ
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