Didar GÜRSOY, İclal GÜRSES, Vedia Bennu GİLAN, Bahar TAŞDELEN, Ali ARICAN, Celalettin TOK

Over Karsinomlarında Östrojen, Progesteron Reseptörleri, C-Erb B-2, P53 ve BRCA1’in İmmünhistokimyasal Ekspresyonu ve Prognostik Önemleri

Çalışmamız ER, PR, C-erbB-2, p53 ve BRCA1 genlerinin immünohistokimyasal ekspresyonunu ve bunların klinikopatolojik özellikler ve prognostik önemi ile ilişkisini belirlemeyi amaçlamaktadır. Çalışmamıza Mersin Üniversitesi Tıp Fakültesi'nde 2002-2012 yılları arasında epitelyal OK tanısı konulan ve takip edilen 85 hasta dahil edildi. ER, PR, C-erbB-2, p53 ve BRCA1'in immünohistokimyasal ekspresyonu ve bunların klinikopatolojik parametrelerle ilişkisi değerlendirildi. Seröz karsinomlarda, ER ekspresyonu fallop tüpüne metastaz ile, PR ekspresyonu hastanın yaşı ile anlamlı şekilde ilişkiliydi, p53 ekspresyonu progresyonsuz sağkalım (PFS) ile anlamlı şekilde ilişkilendirildi, BRCA1'in sitoplazmik ekspresyonu genel sağkalım (OS) ve PFS ile anlamlı şekilde ilişkiliydi. Patogenez gruplarında 55 tümör tip 1 ve 30 tümör tip 2 idi. İki grup arasında ER, PR ve p53 ekspresyonları ile anlamlı korelasyonlar vardı. Çalışmamızda PR ve p53 seröz karsinomda prognostik faktörlerdi. Bu beş immünohistokimyasal belirtecin prognostik değerini belirlemek için her histolojik grupta daha fazla vaka içeren kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

ovarian cancer, hormone receptors, C-erb-B2, P53, BRCA1

Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value

Our study aimed to determine immunohistochemical expression of ER, PR, C-erbB-2, p53 and BRCA1 genes and their relationship with clinicopathological features and prognostic significance. The present study included 85 patients that were diagnosed with epithelial OC, treated and followed-up between 2002 and 2012 at Mersin University, Faculty of Medicine. Immunohistochemical expression of ER, PR, C-erbB-2, p53 and BRCA1 and their relation-ship with clinicopathological parameters were evaluated. In serous carcinomas, expression of ER was significantly associated with metastasis to the fallopian tube, expression of PR was significantly associated with patient’s age, expression of p53 was significantly associated with the progression-free survival (PFS), cytoplasmic expression of BRCA1 was significantly associated with the overall survival (OS) and PFS. In pathogenesis groups, 55 tumors were type 1, and 30 tumors were type 2. There were significant correlations with ER, PR and p53 expressions between the two groups. In our study, PR and p53 were prognostic factors in serous carcinoma. Extensive studies that contain more cases in each histological group are needed to determine the prognostic value of these five immunohistochemical markers.

Keywords:

ovarian cancer, hormone receptors, C-erb-B2, P53, BRCA1,

Tam Metin

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Bibtex	@araştırma makalesi { ksutfd873338, journal = {Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi}, issn = {1303-6610}, eissn = {2547-9598}, address = {}, publisher = {Kahramanmaraş Sütçü İmam Üniversitesi}, year = {2022}, volume = {17}, number = {1}, pages = {121 - 129}, doi = {10.17517/ksutfd.873338}, title = {Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value}, key = {cite}, author = {Gürsoy, Didar and Gürses, İclal and Gilan, Vedia Bennu and Taşdelen, Bahar and Arıcan, Ali and Tok, Celalettin} }
APA	Gürsoy, D. , Gürses, İ. , Gilan, V. B. , Taşdelen, B. , Arıcan, A. & Tok, C. (2022). Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value . Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi , 17 (1) , 121-129 . DOI: 10.17517/ksutfd.873338
MLA	Gürsoy, D. , Gürses, İ. , Gilan, V. B. , Taşdelen, B. , Arıcan, A. , Tok, C. "Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value" . Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 17 (2022 ): 121-129 <
Chicago	Gürsoy, D. , Gürses, İ. , Gilan, V. B. , Taşdelen, B. , Arıcan, A. , Tok, C. "Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value". Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 17 (2022 ): 121-129
RIS	TY - JOUR T1 - Over Karsinomlarında Östrojen, Progesteron Reseptörleri, C-Erb B-2, P53 ve BRCA1’in İmmünhistokimyasal Ekspresyonu ve Prognostik Önemleri AU - DidarGürsoy, İclalGürses, Vedia BennuGilan, BaharTaşdelen, AliArıcan, CelalettinTok Y1 - 2022 PY - 2022 N1 - doi: 10.17517/ksutfd.873338 DO - 10.17517/ksutfd.873338 T2 - Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi JF - Journal JO - JOR SP - 121 EP - 129 VL - 17 IS - 1 SN - 1303-6610-2547-9598 M3 - doi: 10.17517/ksutfd.873338 UR - Y2 - 2021 ER -
EndNote	%0 Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value %A Didar Gürsoy , İclal Gürses , Vedia Bennu Gilan , Bahar Taşdelen , Ali Arıcan , Celalettin Tok %T Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value %D 2022 %J Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi %P 1303-6610-2547-9598 %V 17 %N 1 %R doi: 10.17517/ksutfd.873338 %U 10.17517/ksutfd.873338
ISNAD	Gürsoy, Didar , Gürses, İclal , Gilan, Vedia Bennu , Taşdelen, Bahar , Arıcan, Ali , Tok, Celalettin . "Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value". Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 17 / 1 (Mart 2022): 121-129 .
AMA	Gürsoy D. , Gürses İ. , Gilan V. B. , Taşdelen B. , Arıcan A. , Tok C. Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value. KSÜ Tıp Fak Der. 2022; 17(1): 121-129.
Vancouver	Gürsoy D. , Gürses İ. , Gilan V. B. , Taşdelen B. , Arıcan A. , Tok C. Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi. 2022; 17(1): 121-129.
IEEE	D. Gürsoy , İ. Gürses , V. B. Gilan , B. Taşdelen , A. Arıcan ve C. Tok , "Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value", , c. 17, sayı. 1, ss. 121-129, Mar. 2022, doi:10.17517/ksutfd.873338