Büşra SEĞMEN, Sadık YURTTUTAN, Nurten SERİNGEÇ AKKEÇECİ, Fatma İNANÇ TOLUN, Aydın BOZKAYA

Neonatal Sepsis Şüphesi Olan Yenidoğanlarda Akut Faz Reaktanı Olarak C Reaktif Protein, Prokalsitonin, İnterlökin-18 Düzeylerinin Değerlendirilmesi

Amaç: Neonatal sepsis yaşamın ilk ayında sistemik infeksiyon bulguları ve bakteriyemiyle nitelenen klinik bir sendromdur. Neonatal sepsis neonatal mortalite ve morbiditenin önemli bir nedenidir ve doğru teşhisi için klinik ve laboratuvar bulguların bir kombinasyonu gereklidir. Bu çalışma neonatal sepsisin erken tanı ve takibinde C reaktif protein (CRP), prokalsitonin (PCT) ve İnterlökin-18 (IL-18) düzeylerinin incelenmesi ve karşılaştırılması amacıyla planlanmıştır. Gereç ve Yöntemler: Çalışmaya toplam 103 olgu dahil edildi. Elli beş olgu klinik belirti ve bulgularıyla sepsis grubunu oluşturken, sepsis belirti ve bulgularını taşımayan 48 olgu kontrol grubu olarak çalışmaya dahil edildi. Hastaların demografik özellikleri, prenatal ve maternal özellikleri kaydedildi. Hematolojik bulguları, CRP, PCT ve IL-18 düzeyleri ölçüldü. Bulgular: C reaktif protein (CRP) (53.42±61.94 vs 3.2±0.53 mg/dl, p

Anahtar Kelimeler:

C reaktif protein, İnterlökin-18, Neonatal sepsis, Prokalsitonin

Evaluation of CRP, Procalcitonin, Interleukin-18 Levels as Acute Phase Reactants in Newborns with Suspected Neonatal Sepsis

Objective: Neonatal sepsis is a clinical syndrome characterized by signs of systemic infection and bacteremia in the first month of life. Neonatal sepsis is an important cause of neonatal mortality and morbidity, and a combination of clinical and laboratory findings is required for the correct diagnosis of neonatal sepsis. This study was planned to examine and compare C reactive protein (CRP), procalcitonin (PCT) and Interleukin-18 (IL-18) levels in the early diagnosis and follow-up of neonatal sepsis. Material and Methods: A total of 103 cases were included in the study. While 55 cases with the clinical signs and symptoms were in the sepsis group, 48 cases without the signs and symptoms of sepsis were included in the study as the control group. Demographic characteristics, prenatal and maternal characteristics of the patients were recorded. Hematological findings, CRP, PCT and IL-18 levels were measured. Results: C reactive protein (CRP) (53.42±61.94 vs 3.2±0.53 mg/dl, p

Keywords:

Neonatal sepsis, C reactive protein, Procalcitonin, Interleukin-18,

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