Yak Sığırında SIRT1 ve H-FABP Genlerinde Belirlenen Tek Nükleotid Polimorfizmleri ve Büyüme Özellikleri İle İlişkisi

Bu çalışmanın amacı Yak sığırı yetiştiriciliğinde Sirtuin 1 (SIRT1) ve Kalp tipi yağ asidi bağlayıcı protein (H-FABP) genlerinin kullanılabilirliğinin araştırılmasıdır. Yerel 409 Çin yak sığırında SIRT1 geninin (g.1906A>G) 5’UTR’sinde ve H-FABP geninin (g.6643C>T) ekzon 1’inde olmak üzere iki adet tek nükleotid polimorfizmi (SNP) DNA sekanslama teknolojisi ile tespit edildi. Ki kare testi tüm varyasyonların Hardy-Weinberg denklemi içerisinde olduğunu gösterdi (P>0.05). İlişki analizi, SIRT1 geninin g.1906A>G ve H-FABP geninin g.6643C>T’sinin vücut ağırlığı ve uzunluğu ile anlamlı derecede ilişkili olduğunu gösterdi (P

SNPs Detected in the SIRT1 and H-FABP Genes and Their Association with Growth Traits in Yak

The aims of this study were to investigate whether the Sirtuin 1 (SIRT1) and Hear fatty acid binding protein (H-FABP) genes could be usedas candidate genes in the breeding of yak. In 409 indigenous Chinese yaks, two single nucleotide polymorphisms (SNPs) were identifiedthrough DNA sequencing technology, including a SNP within the 5’UTR of SIRT1 (g.1906A>G), and a SNP in the exon 1 of H-FABP (g.6643C>T).The chi-square test suggested that all the variations were in Hardy-Weinberg equilibrium (P>0.05). An association analysis suggested thatg.1906A>G of SIRT1 gene and g.6643C>T of H-FABP gene exhibited significant correlation with body weight and body length (P

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