Roozbeh MORIDPOUR, Hamidreza FATTAHIAN, Pejman MORTAZAVI

Using Cell-free Matrix Derived from Ostrich Plantar Ligament for Repair of Articular Cartilage Defect of Rabbit

Artikular kartilaj lezyonları dizin en sıklıkla gözlenen yaralanması olup birkaç onarım metodu tanımlanmıştır. Bu çalışmada devekuşunun dizinden ekstrakte edilen kollajen tip I doku iskelesinin in vivo potansiyeli tanımlanmıştır. Ağırlıkları 1800±100 g olan 7 adet Yeni Zelanda ergin erkek tavşanın her iki femurunda femoral kondulusların ağırlık taşıyan bölgelerinde bilateral olarak tüm kat hasarı oluşturuldu. Altı sol medial kondulus hücre içermeyen doku ile doldurulurken (Grup I) aynı tavşanların altı sağ medial kondulus hasarı hücre içeren doku ile tedavi edildi (Grup II) ve bir tavşanın sağ medial kondulus hasarı tedavi uygulanmayarak kontrol grubu olarak bırakıldı. Histopatoloji bulguları kartilaj onarım belirteçleri olarak hücre morfolojisi, renk matriks ve kartilaj kalınlığı bakımlarından her üç grup arasında anlamlı derecede fark olduğunu gösterdi (P

Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı

Articular cartilage lesions are most common injury of the knee for which several repair methods have been described. We described in-vivo potential of collagen type I scaffold extracted fromknee of ostrich. Full thickness defects were created bilaterally in the weight bearing area of femoral condyles of the both femurs of 7 white New zealand adult male rabbits weighting 1800±100 g. The six left medial condyles as experimental group I were filled by using cell-free tissue and six right medial condyles of the same rabbit were treated by cell-tissue as experimental group II and the right medial condyle defect of one rabbit as control group was left without treatment. Histopathology data demonstrated significant difference between three groups with respect to the cartilage repair indicators as the morphology of the cells, color matrix and cartilage thickness (P

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