Latif Emrah YANMAZ, Sıtkıcan OKUR, Uğur ERSOZ, Mümin Gökhan ŞENOCAK, Elif DOĞAN, Zafer OKUMUŞ

The Eff ects of Diff erent Mydriatics on Intraocular Pressure and Central Corneal Thickness in New Zealand White Rabbits

This study was aimed to compare the eff ect of 1% atropine, 1% cyclopentolate, 0.5% tropicamide, and 10% phenylephrine eye drops onintraocular pressure (IOP) and central corneal thickness (CCT) in New Zealand White rabbits. Adult male, eight, New Zealand White rabbits wererandomly received each of four mydriatic eye drops separately on left eye at a one-week washout period. Each rabbit received all of five diff erenttreatments (sterile saline solution, four mydriatic drugs) on the left eye, whereas no measurements were performed on the right eyes during theexperiment. The IOP and CCT recordings of rabbits were performed until the pupil returned to normal diameter. The mean CCT values of sterilesaline, 1% atropine, 0.5% tropicamide, 1% cyclopentolate, and 10% phenylephrine were 370±15, 368±17, 372±15, 364±18, and 360±17 µm,respectively, and no statistically significant diff erences (P>0.05) were observed among groups. The mean IOP values of control (sterile saline), 1%atropine, 0.5% tropicamide, 1% cyclopentolate, and 10% phenylephrine as, 9.7±2.1, 10.4±1.8, 10.3±2.1, 11.0±2.1, and 10±1.8 mmHg, respectively,and these were not statistically significant among groups (P>0.05). In conclusion, topical 1% atropine, 0.5% tropicamide 1% cyclopentolate, and10% phenylephrine do not have significantly eff ect on IOP and CCT in New Zealand white rabbits.

Beyaz Yeni Zelanda Tavşanlarında Farklı Midriyatiklerin Göz İçi Basıncı ve Merkezi Kornea Kalınlığı Üzerine Etkileri

Bu çalışma, Beyaz Yeni Zelanda tavşanlarında %1 atropin, %1 siklopentolat, %0.5 tropikamid ve %10 fenilefrin göz damlasının göz içi basıncı (GİB) ve merkezi kornea kalınlığı (MKK) üzerindeki etkilerini karşılaştırmayı amaçladı. Sekiz, yetişkin erkek Beyaz Yeni Zelanda tavşanının sol gözüne dört ayrı midriyatik göz damlası bir haftalık arınma periyoduyla rastgele uygulandı. Her tavşanın sol gözüne beş farklı tedavinin (steril serum fizyolojik, dört midriyatik ilaç) tamamı uygulanırken, sağ gözlerde ise deney boyunca ölçüm yapılmadı. Tavşanların GİB ve MKK verileri pupil normal çapa dönene kadar alındı. Steril salin, %1 atropin, %0.5 tropikamid, %1 siklopentolat ve %10 fenilefrinin ortalama MKK değerleri sırasıyla 370±15, 368±17, 372±15, 364±18 ve 360±17 µm idi ve gruplar arasında istatistiksel olarak anlamlı farklılık (P>0.05) gözlenmedi. Kontrol (steril salin), %1 atropin, %0.5 tropikamid, %1 siklopentolat ve %10 fenilefrinin ortalama GİB değerleri sırasıyla 9.7±2.1, 10.4±1.8, 10.3±2.1, 11.0±2.1 ve 10±1.8 mmHg’idi ve gruplar arasında istatistiksel olarak önem yoktu (P>0.05). Sonuç olarak, Beyaz Yeni Zelanda tavşanlarında topikal %1 atropin, %0.5 tropikamid, %1 siklopentolat ve %10 fenilefrinin GİB ve MKK üzerinde anlamlı bir etkisi yoktur.

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1. Kovalcuka L, Ilgazs A, Bandere D, Williams DL: Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye. Open Vet J, 7, 16-22, 2017. DOI: 10.4314/ovj.v7i1.3

2. Shih CY, Zivin JSG, Trokel SL, Tsai JC: Clinical significance of central corneal thickness in the managementof glaucoma. Arch Ophthalmol, 122, 1270-1275, 2004. DOI: 10.1001/archopht.122.9.1270

3. Ribeiro AP, Crivelaro RM, Teixeira PPM, Trujillo DY, Guimarães PJ, Vicente WRR, Martins BdC, Laus JL: Effects of different mydriatics on intraocular pressure, pupil diameter, and ruminal and intestinal motility in healthy sheep. Vet Ophthalmol, 17, 397-402, 2014. DOI: 10.1111/ vop.12121

4. Kim JM, Park KH, Han SY, Kim KS, Kim DM, Kim TW, Caprioli J: Changes in intraocular pressure after pharmacologic pupil dilation. BMC Ophthalmol, 12:53, 2012. DOI: 10.1186/1471-2415-12-53

5. Merrill NL, Burge R: Effects of three mydriatic drug regimens on pupil size in rhesus (Macaca mulatta) and African green monkeys (Chlorocebus aethiops). J Med Primatol, 36, 33-38, 2007. DOI: 10.1111/j.1600-0684. 2006.00176.x

6. Herring IP, Pickett JP, Champagne ES, Troy GC, Marini M: Effect of topical 1% atropine sulfate on intraocular pressure in normal horses. Vet Ophthalmol, 3, 139-143, 2000. DOI: 10.1046/j.1463-5224.2000.3230139.x

7. Whelan NC, Castillo-Alcala F, Lizarraga I: Efficacy of tropicamide, homatropine, cyclopentolate, atropine and hyoscine as mydriatics in Angora goats. N Z Vet J, 59, 328-331, 2011. DOI: 10.1080/00480169. 2011.609476

8. Costa D, Leiva M, Coyo N, Laguna F, Ríos J, Peña Gimenez MT: Effect of topical 1% cyclopentolate hydrochloride on tear production, pupil size, and intraocular pressure in healthy Beagles. Vet Ophthalmol, 19, 449-453, 2016. DOI: 10.1111/vop.12323

9. Stadtbäumer K, Frommlet F, Nell B: Effects of mydriatics on intraocular pressure and pupil size in the normal feline eye. Vet Ophthalmol, 9, 233- 237, 2006. DOI: 10.1111/j.1463-5224.2006.00474.x

10. Kovalcuka L, Nikolajenko M: Changes in intraocular pressure, horizontal pupil diameter, and tear production during the use of topical 1% cyclopentolate in cats and rabbits. Open Vet J, 10, 59-67, 2020. DOI: 10.4314/ovj.v10i1.10

11. Mimouni M, Flores V, Shapira Y, Graffi S, Levartovsky S, Sela T, Kaiserman I: Correlation between central corneal thickness and myopia. Int Ophthalmol, 38, 2547-2551, 2018. DOI: 10.1007/s10792-017-0766-1

12. Gao L, Fan H, Cheng AC, Wang Z, Lam DSC: The effects of eye drops on corneal thickness in adult myopia. Cornea, 25, 404-407, 2006. DOI: 10.1097/01.ico.0000214205.29823.f6

13. Wang C, Li AL, Pang Y, Lei YQ, Yu L: Changes in intraocular pressure and central corneal thickness during pregnancy: A systematic review and Meta-analysis. Int J Ophthalmol, 10, 1573-1579, 2017. DOI: 10.18240/ ijo.2017.10.15

14. Bonnemaijer PWM, Cook C, Nag A, Hammond CJ, van Duijn CM, Lemij HG, Klaver CCW, Thiadens AAHJ: Genetic African ancestry is associated with central corneal thickness and intraocular pressure in primary open-angle glaucoma. Investig Ophthalmol Vis Sci, 58, 3172-3180, 2017. DOI: 10.1167/iovs.17-21716

15. Telle MR, Chen N, Shinsako D, Kiland JA, Oikawa K, Møller Trane R, McLellan GJ: Relationship between corneal sensitivity, corneal thickness, corneal diameter, and intraocular pressure in normal cats and cats with congenital glaucoma. Vet Ophthalmol, 22, 4-12, 2019. DOI: 10.1111/ vop.12558

16. Garzón-Ariza A, Guisado A, Galán A, Martín-Suárez E: Diurnal variations in intraocular pressure and central corneal thickness and the correlation between these factors in dogs. Vet Ophthalmol, 21, 464-470, 2018. DOI: 10.1111/vop.12533

17. Haider KM, Mickler C, Oliver D, Moya FJ, Cruz OA, Davitt BV: Age and racial variation in central corneal thickness of preschool and schoolaged children. J Pediatr Ophthalmol Strabismus, 45, 227-233, 2008. DOI: 10.3928/01913913-20080701-07

18. Pauli AM, Bentley E, Diehl KA, Miller PE: Effects of the application of neck pressure by a collar or harness on intraocular pressure in dogs. J Am Anim Hosp Assoc, 42, 207-211, 2006. DOI: 10.5326/0420207

19. Taylor NR, Zele AJ, Vingrys AJ, Stanley RG: Variation in intraocular pressure following application of tropicamide in three different dog breeds. Vet Ophthalmol, 10, 8-11, 2007. DOI: 10.1111/j.1463-5224.2007.00485.x

20. Aksoy O, Gungor E, Kirmizibayrak T, Saroglu M, Ozaydin I, Yayla S: Identification of normal retina’s variations in Kars Shepherd Dogs via fundoscopic examination. Kafkas Univ Vet Fak Derg, 17, 167-170, 2011. DOI: 10.9775/kvfd.2010.2116

21. Slatter DH: Slatter’s fundamentals of veterinary ophthalmology. In, Maggs DJ (Ed): Ocular Pharmacology and Therapeutics. 4th ed., 33-68, St. Louis, Missouri, 2008.

22. Kremer LJ, Reith DM, Medlicott N, Broadbent R: Systematic review of mydriatics used for screening of retinopathy in premature infants. BMJ Paediatr Open, 3:e000448, 2019. DOI: 10.1136/bmjpo-2019-000448

23. Mughannam AJ, Buyukmihci NC, Kass PH: Effect of topical atropine on intraocular pressure and pupil diameter in the normal horse eye. Vet Ophthalmol, 2, 213-215, 1999. DOI: 10.1046/j.1463-5224.1999.00081.x

24. Jugant S, Grillot AE, Lyarzhri F, Régnier A, Douet JY: Changes in pupil size and intraocular pressure after topical application of 0.5% tropicamide to the eyes of dogs sedated with butorphanol. Am J Vet Res, 80, 95-101, 2019. DOI: 10.2460/ajvr.80.1.95

25. Takayama J, Mishima A, Ishii K: Effects of topical phenylephrine on blood flow in the posterior segments of monkey and aged human eyes. Jpn J Ophthalmol, 48, 243-248, 2004. DOI: 10.1007/s10384-004-0051-5

26. Marchini G, Babighian S, Tosi R, Perfetti S, Bonomi L: Comparative study of the effects of 2% ibopamine, 10% phenylephrine, and 1% tropicamide on the anterior segment. Invest Ophthalmol Vis Sci, 44, 281- 289, 2003. DOI: 10.1167/iovs.02-0221

27. Baudouin C, Gastaud P: Influence of topical anesthesia on tonometric values of intraocular pressure. Ophthalmologica, 208, 309- 313, 1994. DOI: 10.1159/000310527

28. Emre S, Akkin C, Afrashi F, Yagci A: Effect of corneal wetting solutions on corneal thickness during ophthalmic surgery. J Cataract Refract Surg, 28, 149-151, 2002. DOI: 10.1016/s0886-3350(01)01029-x

29.Asensio I, Rahhal SM, Alonso L, Palanca-Sanfrancisco JM, SanchisGimeno JA: Corneal thickness values before and after oxybuprocaine 0.4% eye drops. Cornea, 22, 527-532, 2003. DOI: 10.1097/00003226- 200308000-00008

30. Kulualp K, Yurdakul I, Erol H, Atalan G, Kilic S: Measurement of intraocular pressure in clinically normal Turkish shepherd dogs with the rebound tonometer (TonoVet®) and the applanation tonometer (TonoPen Vet®). Med Weter, 74, 568-573, 2018. DOI: 10.21521/mw.6024

31. Dogan E, Yanmaz LE, Senocak MG, Okumus Z: Comparison of propofol, ketamine and ketofol on intraocular pressure in New Zealand white rabbits. Rev Med Vet, 167, 18-21, 2016.

32. Pereira FQ, Bercht BS, Soares MG, da Mota MGB, Pigatto JAT: Comparison of a rebound and an applanation tonometer for measuring intraocular pressure in normal rabbits. Vet Ophthalmol, 14, 321-326, 2011. DOI: 10.1111/j.1463-5224.2011.00879.x

33. Martín-Suárez E, Molleda C, Tardón R, Galán A, Gallardo J, Molleda J: Diurnal variations of central corneal thickness and intraocular pressure in dogs from 8: 00 am to 8: 00 pm. Can Vet J, 55, 361-364, 2014.

34. Chan T, Payor S, Holden BA: Corneal thickness profiles in rabbits using an ultrasonic pachometer. Invest Ophthalmol Vis Sci, 24, 1408-1410, 1983.

35. Wang X, Wu Q: Normal corneal thickness measurements in pigmented rabbits using spectral‐domain anterior segment optical coherence tomography. Vet Ophthalmol, 16, 130-134, 2013. DOI: 10.1111/j.1463- 5224.2012.01041.x