Koyunda Midazolam ile Reversali Flumazenilin Sedatif veKardiyopulmoner Değişkenlere Etkisi

Bu çalışmada koyunlarda midazolam uygulamasının ardından flumazenil antagonizmasıyla sedatif ve kardiyopulmoner değişkenlerdeki etkilerin değerlendirilmesi amaçlanmıştır. Çalışmada en az 14 gün aralıkla İvesi ırkı 6 erkek koyun kullanıldı. Koyunlar midazolam/izotonik serum (MDS) ve midazolam/flumazenil (MDF) olarak rastgele 2 gruba ayrıldı. Her iki grupta midazolam (0.6 mg/kg, IV) uygulamasından önce (baseline) ve uygulamanın 5. (T5) ve 25. dk’sında (T25) hemodinamik değerler ile kan gazı, metabolik ve elektrolit değişken değerleri belirlendi ve refleks değerleri ölçüldü. T25’de MDS’ye izotonik serum solüsyonu, MDF’ye flumazenil (0.02 mg/kg, IV) enjekte edildi. İzotonik serum ve flumazenil uygulamalarının 5. dk (T30), 35. dk (T60) ve 65. dk (T90)’larında aynı ölçümler tekrarlandı. Belirlenen zamanlarda midazolam her iki grupta derin sedasyon ve refleks değerlerde önemli yükselme sağladı (P

The Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep

The aim of this study was to investigate the effects of flumazenil antagonism after midazolam administration on sedative and cardiopulmonary variables in ewes. Six Awassi ewes were studied at least 14 days apart. The ewes were randomly divided into two groups as midazolam/ saline (MDS) and midazolam/flumazenil (MDF). Hemodynamic values, blood gas, metabolic and electrolyte variables and reflex values were determined in both groups before midazolam (0.6 mg/kg, IV) administration (baseline) and after the 5th (T5) and 25th min (T25) of administration. At T25, saline was injected into the MDS and flumazenil (0.02 mg/kg, IV) into the MDF. The same measurements were repeated at the 5th min (T30), 35th min (T60), and 65th min (T90) of saline and flumazenil applications. Midazolam produced deep sedation and a significant increase in reflex scores in both groups at the indicated times (P

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