David FARRAY, Francisco RODRIGUEZ, Antonio RAVELO-GARC A, Alejandro SUAREZ-BONNET, Carla FRANCISCO-ARTEAGA, Jose Raduan JABER

Investigation of Correlations Between Clinical Signs and Pathological Findings in Cats and Dogs with Inflammatory Bowel Disease

This paper compares the correlation between the clinical signs and the histopathological observations of the entire intestine in cats and dogs with inflammatory bowel disease (IBD). To perform this study, hospital records of 53 dogs and 20 cats of different sex, ages, and breed diagnosed with IBD following the histopathological criteria of the World Small Animal Veterinary Association (WSAVA) were evaluated. The results obtained in this study did show correlations between some clinical signs and the histopathological assessment of dogs and cats with IBD. Therefore, a slight association between diarrhea and lacteal dilation in the small bowel, and diarrhea and desquamation in the large bowel of dogs with IBD was seen, but no other associations were found between the rest of the lesions and symptoms. In contrast, cats only showed a correlation between anorexia with villous stunting and villous epithelial injury, without correspondence among other clinical signs and lesions. The results of this study propose that the evaluation of IBD can be complicated, especially with the use of retrospective records of archived intestinal biopsies and subjective clinical and histopathologic decisions.

İnflamatuar Bağırsak Hastalığı Olan Kedi ve Köpeklerde Klinik Bulgular İle Patolojik Bulgular Arasındaki İlişkilerin Araştırılması

Bu makale, inflamatuar bağırsak hastalığı (IBD) olan kedi ve köpeklerde bütün bağırsakların klinik bulguları ile histopatolojik gözlemleri arasındaki korelasyonu karşılaştırmaktadır. Bu çalışmayı gerçekleştirmek için, World Small Animal Veterinary Association (WSAVA)’in histopatolojik kriterlerini izleyerek IBD tanısı konan farklı cinsiyet, yaş ve ırkta 53 köpek ve 20 kedinin hastane kayıtları değerlendirildi. Bu çalışmada elde edilen sonuçlar, IBD’li köpek ve kedilerde bazı klinik bulgular ile histopatolojik bulgular arasında korelasyon olduğunu gösterdi. Bu nedenle, IBD’li köpeklerde ince bağırsakta ishal ve lakteal dilatasyon ile kalın bağırsakta ishal ve deskuamasyon arasında hafif bir ilişki görülmüştür, ancak lezyonların geri kalanı ve semptomlar arasında başka bir ilişki bulunmamıştır. Buna karşın, kedilerde diğer klinik bulgular ve lezyonlar arasında ilişki saptanmezken, sadece anoreksi ile villöz gelişim eksikliği ve villöz epitel hasar arasında bir korelasyon vardı. Bu çalışmanın sonuçları, özellikle intestinal biyopsilerinin arşivlenmiş retrospektif kayıtlarının subjektif klinik ve histopatolojik kararlarının kullanılması ile IBD değerlendirmesinin karmaşık olabileceğini düşündürmektedir.

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