Fibrothecoma in A trough bred mare with unilateral ovariectomy: A case report

İki yıldır kısırlık izlenen, 10 yaşında Ingiliz ırkı bir kısrağın sol ovaryumunda bütün ovaryumu kaplayan sıkı-solit yapıda tümöral kitle saptandı. Kitlenin kesit yüzü beyaz sarı renkte ve helazonik görüntüdeydi. Histolojik olarak keşisen demetler oluşturan, mekik şekilli bir örnek hücre kümeleri izlendi. Stromada Mallory’nin triple boyası ile maviye boyanan intersellüler kollagen içeren sıkı fibröz alanların yanısıra, gevşek alanlar da izlendi. Odaksal olarak mekik hücrelerinde tekal diff erensiyasyonun belirtisi olan, çok sayıda vakuolizasyon izlendi. Tümöral kitlede ne seks kord hücreleri adacıkları ne de granuloza hücreleri izlendi. Mitotic indeks ortalama 2 hücre ve daha azdı. İmmunohistokimyasal olarak mekik şekilli hücreler vimentin ile pozitif olarak işaretlenirken, bazı bölgerde desmin ve düz kas aktini ile tren rayı görüntüsünde zayıf immunreaksiyon izlendi. Morfolojik ve histolojik bulguların ışığında tümor fibrotekoma olarak adlandırıldı.

Anahtar Kelimeler:

at, immünohistokimya, kısrak, neoplazma, yumurtalıklar

Maretek taraflı ovariektomi yapılan bir İngiliz atında fibrotekoma: olgu sunumu

A solid and firm tumor, covering the whole left ovary was detected in 10 years old a troughbred mare, which had a 2-year history of infertility. The cut surface of the mass was whitish-yellow with whorled appearance. Histologically, tumor was composed of uniform spindle cells arranged intersecting fascicles. Intercellular kollagen, which was stained blue with Mallory’s triple was observed in stroma. Focally, the spindle cells showed abundant vacuolated cytoplasm, which was a feature for thecal diff erentiation. Neither sex cord islands nor granulosa cells were observed in that tumor. The mitotic amount averaged less than 2 cells. Immunohistochemically, the spindle-shaped neoplastic cells were positive for vimentin, whereas only weak tram-track immunoreactivity was demonstrable for desmin and smooth muscle actin. Based on the morphological and histological features, the tumor was classified as a fibrothecoma.

Keywords:

horses, immunohistochemistry, mares, neoplasms, ovaries,

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