RAMAZAN DURGUT, Doğan DALKILINÇ, MURAT GÜZEL

Evaluation of the serum lipid profiles in dogs with symptomatic visceral leishmaniasis

Bu çalışmanın amacı doğal enfekte visseral leishmaniasisli semptom gösteren köpeklerde lipit profilindeki değişiklikleri araştırmaktır. 10 sağlıklı ve 10 L. infantum ile enfekte toplam 20 sahipli köpek bu çalışmaya dahil edildi. Bütün köpeklerin anamnez bilgileri alındı ve fiziksel muayeneleri yapıldı. Enfekte köpeklerde visseral leishmaniasisin (VL) deri lezyonları, ağırlık kaybı, konjiktivitis, alopesi, kepeklenme, tırnaklarda uzama, lenfadenopati, güçsüzlük, iştahsızlık, epistaksis semptomlarından bir veya birkaçı tespit edildi. Canin visseral leishmaniasisin (CVL) teşhisi immunofluoresens antikor testi (IFAT) ve antikor titresinin 1:128’e eşit veya üzerinde belirlenmesi ile doğrulandı. Sağlıklı köpeklerin hiç birinde klinik semptom yoktu ve leishmania antikoru tespit edilmedi. Bu çalışmada semptomatik köpeklerde serum kolesterol, çok düşük dansiteli lipopretein (VLDL) ve düşük dansiteli lipopretein (LDL) seviyelerinin kontrol grubu verileriyle karşılaştırıldığında yüksek bulundu (P

Anahtar Kelimeler:

düşük yoğunluklu lipoprotein, Leishmania donovani, hayvan patolojisi, kan kimyası, viseral layşmanyaz, kan lipitleri, kolesterol, klinik görünüm, köpek, yüksek yoğunluklu lipoprotein, lipoprotein, triyosilgliserol

Semptomatik Leishmaniasisli köpeklerde serum lipit profilinin değerlendirilmesi

The aim of this study was to investigate the serum lipid profile in naturally infected symptomatic dogs with visceral leishmaniasis (VL). A total of 20 owned dogs, comprising 10 healthy controls and 10 infected dogs with L. infantum were enrolled in this study. The clinical history and physical examination were performed in all dogs. Infected dogs showed one or more signs of canine leishmaniasis such as skin lesions, loss of weight, conjunctivitis, alopecia, scaling, onychogryphosis, lymphadenopathy, weakness, anorexia, and epistaxis. The diagnosis of canine visceral leishmaniasis (CVL) was confirmed by the immunofluorescence antibody test (IFAT) with an antibody titer over or equal to 1:128. None of the healthy dogs had clinical signs consistent with any of the disease and were all seronegative for leishmaniasis. In this study, serum cholesterol, very low density lipoprotein (VLDL) and low density lipoprotein (LDL) levels were significantly higher (P<0.01) in symptomatic dogs when compared to control animals. However, triglyceride and high density lipoprotein (HDL) levels were lower (P<0.01) than those of the controls. In conclusion, it was determined that CVL induce significant changes in serum lipid profile.

Keywords:

low density lipoprotein, Leishmania donovani, animal pathology, blood chemistry, visceral leishmaniasis, blood lipids, cholesterol, clinical aspects, dogs, high density lipoprotein, lipoproteins, triacylglycerols,

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