Etlik Piliçlerde Pulmoner Hipertansiyon ve Kalp Yetmezliğini Engellemede Etkili Bir Tıbbi Bitki Türü Olarak Alıç (Crataegus oxyacantha) Flavanoid Ekstraktı

Bu çalışmanın amacı, yüksek irtifada yetiştirilen broiler tavuklarında pulmoner hipertansiyon sendromunun (PHS) önlenmesinde alıç flvonoid ekstraktının etkisini araştırmaktır. 42 gün süreli çalışmada, 225 adet 1 günlük broiler tavuk (Ross-308) farklı içme suyu seviyelerindeki alıç flvanoid ekstraktlarına göre (0, 0.1 ve 0.2 mL/L içme suyu) rastgele üç uygulama grubuna ayrıldı. Başlangıç ve büyüme evrelerinde tüm çalışma süresince 0.1 ve 0.2 mL/L içme suyu oranında alıç flvanoid ekstraktı tüketen broiler tavuklarda anlamlı derecelerde vücut ağırlık kazanımı artarken yem konversiyon oranı azaldı (P

Hawthorn (Crataegus oxyacantha) Flavonoid Extract as an Effctive Medicinal Plant Derivative to Prevent Pulmonary Hypertension and Heart Failure in Broiler Chickens

The aim of this study was to investigate the effct of crateagus flvonoid extract in preventing pulmonary hypertension syndrome (PHS) in broiler chickens reared at high altitude, encountered ascites was evaluated. A 225 day-old broiler chickens (Ross-308) were randomly assigned to three treatments including diffrent drinking levels of crateagus flvonoid extract (0, 0.1, and 0.2 mL per liter of drinking water) in a 42-day trial. Body weight gain were increased and feed conversion ratio were decreased significantly (P

___

  • Ahmadipour B, Hassanpour H, Asadi E, Khajali F, Rafiei F, Khajali F: Kelussia odoratissima Mozzaf - A promising medicinal herb to prevent pulmonary hypertension in broiler chickens reared at high altitude. J Ethnopharmacol, 159, 49-54, 2015. DOI: 10.1016/j.jep.2014.10.043
  • Khajali F, Fahimi S: Inflence of dietary fat source and supplementary alpha-tocopheryl acetate on pulmonary hypertension and lipid peroxidation in broilers. J Anim Physiol Anim Nutr, 94 (6): 767-772, 2010. DOI: 10.1111/j.1439-0396.2009.00959.x
  • Behrooj N, Khajali F, Hassanpour H: Feeding reduced-protein diets to broilers subjected to hypobaric hypoxia is associated with the development of pulmonary hypertension syndrome. Br Poult Sci, 53 (5): 658-664, 2012. DOI: 10.1080/00071668.2012.727082
  • Khajali F, Saedi M: The effct of low chloride and high bicarbonate diets on growth, blood parameters, and pulmonary hypertensive response in broiler chickens reared at high altitude. Archiv für Geflgelkunde, 75, 235- 238, 2011.
  • Wideman RF, Rhoads DD, Erf GF, Anthony NB: Pulmonary arterial hypertension (ascites syndrome) in broilers: A review. Poult Sci, 92 (1): 64- 83, 2013. DOI: 10.3382/ps.2012-02745
  • Izadinia M, Nobakht M, Khajali F, Faraji M, Zamani F, Qujeq D, Karimi I: Pulmonary hypertension and ascites as affected by dietary protein source in broiler chickens reared in cool temperature at high altitudes. Anim Feed Sci Technol, 155 (2-4): 194-200, 2010. DOI: 10.1016/j. anifeedsci.2009.12.009
  • Khajali F, Liyanage R, Wideman RF: Methylglyoxal and pulmonary hypertension in broiler chickens. Poult Sci, 90 (6): 1287-1294, 2011. DOI: 10.3382/ps.2010-01120
  • Saki A, Haghighat M, Khajali F: Supplemental arginine administered in ovo or in the feed reduces the susceptibility of broilers to pulmonary hypertension syndrome. Br Poult Sci, 54 (5): 575-580, 2013. 10.1080/00071668.2013.811716
  • Chang Q, Zuo Z, Harrison F, Chow MSS: Hawthorn. J Clin Pharmacol, 42 (6): 605-612, 2002. DOI: 10.1177/00970002042006003
  • Kirakosyan A, Seymour E, Kaufman PB, Warber S, Bolling S, Chang SC: Antioxidant capacity of polyphenolic extracts from leaves of Crataegus laevigata and Crataegus monogyna (Hawthorn) subjected to drought and cold stress. J Agric Food Chem, 51 (14): 3973-3976, 2003. DOI: 10.1021/jf030096r
  • Salehi S, Long SR, Proteau PJ, Filtz TM: Hawthorn (Crataegus monogyna Jacq.) extract exhibits atropine-sensitive activity in a cultured cardiomyocyte assay. J Nat Med, 63 (1): 1-8, 2009. DOI: 10.1007/s11418-008-0278-4
  • Bottje WG, Wideman RF: Potential role of free radicals in the pathogenesis of pulmonary hypertension syndrome. Poult Avian Biol Rev, 6, 211-231, 1995.
  • Yu BP: Cellular defenses against damage from reactive oxygen species. Physiol Rev, 74 (1): 139-162, 1994. DOI: 10.1152/physrev.1994.74.1.139
  • Cawthon D, Beers K, Bottje WG: Electron transport chain defect and inefficient respiration may underlie pulmonary hypertension syndrome (ascites)-associated mitochondrial dysfunction in broilers. Poult Sci, 80 (4): 474-484, 2001. DOI: 10.1093/ps/80.4.474
  • Nain S, Wojnarowicz C, Laarveld B, Olkowski AA: Effcts of dietary vitamin E and C supplementation on heart failure in fast growing commercial broiler chickens. Br Poult Sci, 49 (6): 697-704, 2008. DOI: 10.1080/00071660802415658
  • Ladmakhi MH, Buys N, Dewil E, Rahimi G, Decuypere E: The prophylactic effect of vitamin C supplementation on broiler ascites incidence and plasma thyroid hormone concentration. Avian Pathol, 26 (1): 33-44, 1997. DOI: 10.1080/03079459708419191
  • Tekeli A: Effct of rosehip fruit (Rosa canina l.) supplementation to rations of broilers grown under cold stress conditions on some performance, blood, morphological, carcass and meat quality characteristics. Europ Poult Sci, 78, 1612-9199, 2014. DOI: 10.1399/eps.2014.19
  • Julian RJ: The response of the heart and pulmonary arteries to hypoxia, pressure, and volume. A short review. Poult Sci, 86 (5): 1006-1011, 2007. DOI: 10.1093/PS/86.5.1006
  • Seevers PM, Daly JM: Studies on wheat stem rust resistance controlled at the Sr6 locus. II. Peroxidase activities. Phytopathology 60 (11): 1642-1647, 1970. DOI: 10.1094/Phyto-60-1642
  • Chapman ME, Wideman Jr RF: Evaluation of total plasma nitric oxide concentrations in broilers infused intravenously with sodium nitrite, lipopolysaccharide, aminoguanidine, and sodium nitroprusside. Poult Sci, 85 (2): 312-320, 2006. DOI: 10.1093/ps/85.2.312
  • Nair V, Turner GA: The thiobarbituric acid test for lipid peroxidation: Structure of the adduct with malondialdehyde. Lipids, 19 (10): 804-805, 1984. DOI: 10.1007/bf02534475
  • Saedi M, Khajali F: Blood gas values and pulmonary hypertension as affcted by dietary sodium source in broiler chickens reared at cool temperature in a high-altitude area. Acta Vet Hung, 58 (3): 379-388, 2010. DOI: 10.1556/AVet.58.2010.3.10
  • Rehman ZU, Worku T, Davis JS, Talpur HS, Bhattarai D, Kadariya I, Hua G, Cao J, Dad R, Farmanullah, Hussain T, Yang L: Role and mechanism of AMH in the regulation of Sertoli cells in mice. J Steroid Biochem Mol Biol, 174, 133-140, 2017. DOI: 10.1016/j.jsbmb.2017.08.011
  • Ruijter JM1, Ramakers C, Hoogaars WM, Karlen Y, Bakker O, van den Hof MJ, Moorman AF: Amplification efficiency: Linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res, 37 (6): e45, 2009. DOI: 10.1093/nar/gkp045
  • Dorak M: Real Time PCR. Taylor & Francis, Oxford, UK, 2006.
  • Surai PF: Polyphenol compounds in the chicken/animal diet: From the past to the future. J Anim Physiol Anim Nutr, 98 (1): 19-31, 2014. DOI: 10.1111/jpn.12070
  • Belge C, Massion PB, Pelat M, Balligand JL: Nitric oxide and the heart: Update on new paradigms. Ann N Y Acad Sci, 1047 (1): 173-182, 2005. DOI: 10.1196/annals.1341.016
  • Hassanpour H, Yazdani A, Khabir Soreshjani K, Asgharzadeh S: Evaluation of endothelial and inducible nitric oxide synthase genes expression in the heart of broiler chickens with experimental pulmonary hypertension. Br Poult Sci, 50 (6): 725-732, 2009. DOI: 10.1080/ 00071660903141005
  • Munshi-South J, Wilkinson GS: Bats and birds: Exceptional longevity despite high metabolic rates. Ageing Res Rev, 9 (1): 12-19, 2010. DOI: 10.1016/j.arr.2009.07.006
  • Sohal RS, Weindruch R: Oxidative stress, caloric restriction, and aging. Science, 273 (5271): 59-63, 1996. DOI: 10.1126/science.273.5271.59
  • Nagy KA: Field metabolic rate and body size. J Exp Biol, 208: 1621- 1625, 2005. DOI: 10.1242/jeb.01553
  • Braun EJ, Sweazea KL: Glucose regulation in birds. Comp Biochem Physiol B Biochem Mol Biol, 151 (1): 1-9, 2008. DOI: 10.1016/j.cbpb. 2008.05.007
  • Jorge VG, Angel JR, Adrian TS, Francisco AC, Anuar SG, Samuel ES, Angel SO, Emmanuel HN: Vasorelaxant activity of extracts obtained from Apium graveolens: possible source for vasorelaxant molecules isolation with potential antihypertensive effct. Asian Pac J Trop Biomed, 3 (10): 776-779, 2013. DOI: 10.1016/s2221-1691(13)60154-9
  • Barros L, Carvalho AM, Ferreira ICFR: Comparing the composition and bioactivity of Crataegus Monogyna flwers and fruits used in folk medicine. Phytochem Anal, 22 (2): 181-188, 2011. DOI: 10.1002/pca.1267
  • Liu J: Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol, 49 (2): 57-68, 1995. DOI: 10.1016/0378-8741(95)90032-2
  • Sajjadi SE, Shokoohinia Y, Moayedi NS: Isolation and identifiation of ferulic acid from aerial parts of Kelussia odoratissima Mozaff Jundishapur J Nat Pharm Prod, 7 (4): 159-162, 2012.
  • Mills S, Bone K: Principles and practice of phytotherapy. Modern Herbal Medicine. Churchill Livingstone, 2000.
  • Özcan M, Hacıseferoğulları H, Marakoğlu T, Arslan D: Hawthorn (Crataegus spp.) fruit: Some physical and chemical properties. J Food Eng, 69 (4): 409-413, 2005. DOI: 10.1016/j.jfoodeng.2004.08.032
  • Zulkifli I, Che Norma MT, Chong CH, Loh TC: Heterophil to lymphocyte ratio and tonic immobility reactions to preslaughter handling in broiler chickens treated with ascorbic acid. Poult Sci, 79 (3): 402-406, 2000. DOI: 10.1093/ps/79.3.402
  • Rajendran S, Deepalakshmi PD, Parasakthy K, Devaraj H, Devaraj SN: Effct of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis, 123 (1- 2): 235-241, 1996.
  • Zhang Z, Ho WKK, Huang Y, James AE, Lam LW, Chen ZY: Hawthorn fruit is hypolipidemic in rabbits fed a high cholesterol diet. J Nutr, 132 (1): 5-10, 2002. DOI: 10.1093/JN/132.1.5
  • Long SR, Carey RA, Crofoot KM, Proteau PJ, Filtz TM: Effct of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay. Phytomedicine, 13 (9-10): 643-650, 2006. DOI: 10.1016/J.PHYMED.2006.01.005
  • Chen JJ, Li XR: Hypolipidemic effct of flvonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice. Asia Pac J Clin Nutr, 16 (Suppl. 1): 290-294, 2007.
  • Kouba M, Catheline D, Leclercq B: Lipogenesis in turkeys and chickens: A study of body composition and liver lipogenic enzyme activities. Br Poult Sci, 33 (5): 1003-1014, 1992. DOI: 10.1080/00071669208417543
  • Chu Y, Iida S, Lund DD, Weiss RM, DiBona GF, Watanabe Y, Faraci FM, Heistad DD: Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats. Circ Res, 92 (4): 461-468, 2003. DOI: 10.1161/01.RES.0000057755.02845.F9
  • Brixius K, Willms S, Napp A, Tossios P, Ladage D, Bloch W, Mehlhorn U, Schwinger RHG: Crataegus special extract WS® 1442 induces an endothelium-dependent, NO-mediated vasorelaxation via eNOSphosphorylation at serine 1177. Cardiovasc Drugs Ther, 20 (3): 177-184, 2006. DOI: 10.1007/s10557-006-8723-7
  • Lu Q, Qiu TQ, Yang H: Ligustilide inhibits vascular smooth muscle cells proliferation. Eur J Pharmacol, 542 (1-3): 136-140, 2006. DOI: 10.1016/j. ejphar.2006.04.023
  • Mladěnka P, Zatloukalová L, Filipský T, Hrdina R: Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic Biol Med, 49 (6): 963-975, 2010. DOI: 10.1016/j.freeradbiomed. 2010.06.010
Kafkas Üniversitesi Veteriner Fakültesi Dergisi-Cover
  • ISSN: 1300-6045
  • Yayın Aralığı: 6
  • Başlangıç: 1995
  • Yayıncı: Kafkas Üniv. Veteriner Fak.
Sayıdaki Diğer Makaleler

Pakistan’ın Barani Bölgesi’nde Koyunlarda Mide-Bağırsak Nematodlarına Karşı Bazı Antelmintiklerin Etkisi ve Direncin İzlenmesi

Shahzad ALI, Ali MUHAMMAD, Muhammad SAQLAIN, Mazhar QAYYUM, Haroon AHMED, Sami ŞİMŞEK

Associations Between Forkhead Box L2 Expression and Ovary Development in Laying Hens

Shouping ZHANG, Xiaojing XIA, Lirong WANG, Renfeng LI, Meng YANG, Sanhu WANG

Evaluation of Intramammary Platelet Concentrate Efficacy as a Subclinical Mastitis Treatment in Dairy Cows Based on Somatic Cell Count and Milk Amyloid A Levels

GAMZE EVKURAN DAL, AHMET SABUNCU, SİNEM ÖZLEM ENGİNLER, Ali Can ÇETİN, BARAN ÇELİK, ÖMÜR KOÇAK

Köpeklerde Mekanik Hasar ve Alkali Yakma İle Oluşturulan Derin Korneal Ülserde Amniyon Sıvısı Süpernatantı Göz Damlası İle Birlikte Kullanılan Konjuktiva Örtüsünün Etkinliği

Zheng WANG, Renyue WEI, Jiaren ZHANG, Hongri RUAN, Tingtig ZHU, Jun SONG, Jiasan ZHENG

Efficacy of Probiotics on Health Status and Growth Performance of Eimeria tenella Infected Broiler Chickens

S. Zerrin ERDOĞMUŞ, Nurhayat GÜLMEZ YECAN, Ayfer FINDIK, Hüseyin ŞAH, Murat GÜLMEZ

Buzağılarda Sıcak Koter İle Boynuzsuzlaştırmanın Tiyol-Disülfit Homeostazı Üzerine Etkisi

Songül ERDOĞAN, Hasan ERDOĞAN, İlker ÇAMKERTEN, Güzin ÇAMKERTEN, Kerem URAL, İsmail GÜNAL, Özcan EREL

Protective Effct of Ozone Against Gentamicin-Induced Neprotoxicity and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels: An Experimental Study

SEFER ÜSTEBAY, Döndü Ülker ÜSTEBAY, Ömür ÖZTÜRK, Ömer ERTEKİN, YASEMEN ADALI

Chinchilla (Chinchilla lanigera) Tarsus’unda Üç Boyutlu Rekontrüksiyon Görüntülerine Dayalı Biyometrik Oranlar

Sema ÖZKADİF, Ayşe HALIGÜR, Emrullah EKEN

Yumurtacı Tavuklarda Ovaryum Gelişimi İle Forkhead Box L2 Ekspresyonu Arasındaki İlişki

Sanhu WANG, Meng YANG, Xiaojing XIA, Renfeng LI, Shouping ZHANG, Lirong WANG

Erken Osteojenik Farklılaşma (In Vitro) Süresince Wistar Sıçanlarda (Rattus novergicus) Gingival Medicinal Signaling Hücrelere Post Trombositten Zengin Fibrin Uygulamasının Agrekan Ekspresyonuna Etkisi

Fedik Abdul RANTAM, Wibi RIAWAN, Ida Bagus NARMADA, Diah Savitri ERNAWATI, Igo Syaiful IHSAN, Aristia DINARYANTI, Alexander Patera NUGRAHA, Eryk HENDRIANTO