KADİR BOZUKLUHAN, OĞUZ MERHAN, HALİL İBRAHİM GÖKCE, METİN ÖĞÜN, EMİNE ATAKİŞİ, Şemistan KIZILTEPE, Gürbüz GÖKÇE

Determination of Some Acute Phase Proteins, Biochemical Parameters and Oxidative Stress in Sheep with Naturally Infected Sheeppox Virus

The aim of the present study was to determine oxidative stress and acute phase response in naturally infected sheep with poxvirus. For this purpose, 20 poxvirus infected and 10 clinically healthy sheep were used in the study. In these animals, alkaline phosphatase (ALP), aspartate aminotransferase (AST) activity, haptoglobin, ceruloplasmin, urea, creatinine, albumin, iron (Fe), malondialdehyde (MDA) and reduced glutathione (GSH) concentrations were determined. The present study determined that the concentrations of haptoglobin, ceruloplasmin, urea, creatinine, MDA and ALP, AST activity were significantly increased, and albumin, Fe and GSH concentrations were significantly decreased in the sheeppox virus infected group compared to the control group. Results of this study indicated that oxidative stress and acute phase response develop in sheep infected with poxvirus.

Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi

Çalışma poksvirüs ile doğal enfekte koyunlarda, oksidatif stres ve akut faz cevabı belirlemek amacıyla yapıldı. Çalışmada 20 adet çiçek hastalığı ile enfekte ve 10 adet klinik olarak sağlıklı koyun kullanıldı. Hayvanlarda alkalen fosfataz (ALP), aspartat aminotransferaz (AST) aktivitesi, haptoglobin, seruloplazmin, üre, kreatinin, albümin, demir (Fe), malondialdehit (MDA) ve redükte glutatyon (GSH) konsantrasyonları belirlendi. Çalışmada, poksvirus ile enfekte koyunlar ile kontrol grubundaki hayvanlar karşılaştırıldığında haptoglobin, seruloplazmin, üre, kreatinin, MDA değerleri ile ALP ve AST aktivitelerinin yükseldiği, albümin, Fe ve GSH konsantrasyonunun ise kontrol grubuna göre düştüğü belirlendi. Bu çalışmada poksvirus ile enfekte koyunlarda akut faz yanıtın oluştuğu ve oksidatif stresin geliştiği kanısına varıldı.

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