İBRAHİM DEMİRKAN, TOLGA ERTEKİN, MUSA KORKMAZ, İBRAHİM KILIÇ, AYSUN ÇEVİK DEMİRKAN, MEHMET FATİH BOZKURT, Ahmet KONUKTÜRK

Antitumorigenic Activity of the Herbal Mixture-AK27 on Ehrlich Ascites Carcinoma in Mice

Kanser sağaltımı oldukça zor ve hastanın sağlığı üzerine olumsuz etkileri olan cerrahi, kemoterapi ve radyoterapinin tek başına veya kombinasyonlarını kapsar. Bu çalışmanın amacı antep fıstığı reçinesi, sumak reçinesi, polen, çörek otu tohumu, nar kabuğu ve zeytinyağı kombinasyonundan oluşan AK27-bitkisel karışımın muhtemel antineoplaistik etkinliğini fare modelinde deneysel oluşturulan Ehrlich asites karsinomunda (EAK) göstermektir. EAK'lı fareler tümör hücre sayısı (canlı ve ölü), ortalama yaşam süresi, yaşam süresinde yüzde artış ve canlı ağırlık değişimi yönünden değerlendirildi. En yüksek canlı hücre sayısı (ortalama 15.5x107/mL/fare) ve EAK hacmi (ortalama 12 mL/fare) kanser grubunda ölçüldü. AK27 karışımının tümör oluşturulmasından önce verilmesi EAK gelişimini engellerken aynı anda veya tümör oluştuktan sonra verilmesi kanser kontrol grubu ile karşılaştırıldığında canlı EAK hücre sayısını anlamlı düzeyde azalttığı gözlendi. Dördüncü günden itibaren 12. güne kadar canlı ağırlık artışı bakımında gruplararasında anlamlı farklar tespit edildi (P

Farelerde AK27 Bitkisel Karışımının Ehrlich Ascites Karsinoma Üzerine Antitümorijenik Etkisi

The treatment of cancer is highly challenging and contains surgery, chemotherapy and radiotherapy alone or combinations which have various side effects on the patient health. This study aimed at observing the possible antineoplastic activity of AK27-herbal mixture, a combination of pistachio resin, rhus resin, pollen, Nigella sativa seed, pomegranate skin and olive oil, on experimentally induced Ehrlich ascites carcinoma (EAC) in a mouse model. EAC-bearing mice were evaluated by tumor cell count (viable and non-viable), median survival time, percentage increase in the life span and live body weight changes up to 30 days of EAC inoculation. Volume of EAC cells and viable cell count were found to be significantly decreased in AK27 treated groups when compared to EAC control group (P

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