The virus diffusion in a ventilated room with the droplets produced by coughing and breathing are presented by the Lagrangian model. When the human body is located in the middle of the room with two locations of AC, in front of and behind the human body, three angles of Air Conditioning (AC) gate are applied 0°, 30°, and 60° to show droplet particle diffusion in the room in these cases. Three types of coughing velocity profiles were selected, real human coughing, sinusoidal cough, and cough jet with one velocity profile of breathing as a step function to cover the inhaling and exhaling cycle. The simulation results show that the uncovered standing in the middle of the room, are more susceptible to infection for the bouncy and forced flow around the human body. Droplet particle moves in the room as a random diffusion and it is very sensitive to the thermal load inside the room, generally depends on the bouncy force and pressure force due to convection heat transfer. when the AC location at the opposite direction of coughing flow, the droplet travels a distance of about 3 m, 2.85 m, and 2.75 m for real cough, sinusoidal cough, and cough jet respectively. While the droplet travel distance is about 3.1 m, 3.2 m, and 2.9 m when the AC location is at the same direction of coughing flow. Finally, the adopted CFD modeling was also used to show the effects of different AC locations on coughing, breathing particle droplets distribution in different indoor spaces, such as buildings, hospitals, and public transports, Also, showed good visual demonstration and representation of the real physical processes.