Electrochemical Study of 17β-Estradiol and its Determination in Pharmaceutical Preparations using Square Wave Voltammetry

Electrochemical Study of 17β-Estradiol and its Determination in Pharmaceutical Preparations using Square Wave Voltammetry

In the present study, the electroanalytical behavior of 17β-estradiol was investigated using cyclic voltammetry. The procedure was based on 17β-estradiol being electrochemically oxidized at a platinum electrode in non-aqueous solutions. At 1.47 V, the oxidation peak was noted. It was discovered that 17β-estradiol's oxidation was diffusion-controlled. Additionally, a quick and easy square wave voltammetry method was developed and validated in this work to determine 17β-estradiol in pharmaceutical preparations. The calibration curve was linear at 5 and 30 µg/mL concentrations. The precision was given by relative standard deviation and was less than 3.36%. Accuracy was given with relative error and did not exceed 2.54%. In pharmaceutical preparations, 17β-estradiol had an average recovery of 100.3%. Under the chosen experimental conditions, no interference was found. The suggested method is highly accurate and precise. Therefore, the method applies to measuring 17β-estradiol in pharmaceutical formulations.


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Vancouver Yılmaz B. , Kadıoğlu Y. Electrochemical Study of 17β-Estradiol and its Determination in Pharmaceutical Preparations using Square Wave Voltammetry. Journal of the Turkish Chemical Society Section A: Chemistry. 2023; 10(3): 589-598.
Journal of the Turkish Chemical Society Section A: Chemistry
  • Yayın Aralığı: Yılda Yılda 4 Sayı
  • Yayıncı: Türkiye Kimya Derneği


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