İlk trimester hemoglobin değerinin olumsuz gebelik sonuçları üzerine etkileri

Amaç: Literatürde yapılan çalışmalarda farklı hemoglobin (Hb) düzeylerinin postpartum hemoraji, gebelik ile indüklenen hipertansiyon, intrauterin gelişme geriliği, gestasyonel diabetes mellitus ve perinatal mortalite gibi olumsuz gebelik sonuçları ile ilişkisi gösterilmiştir. Bu çalışmanın amacı gebeliğin ilk üç ayında ölçülen hemoglobin (Hb) düzeylerinin gebelik sonuçları üzerindeki etkilerini araştırmak ve Hb'nin olumsuz gebelik sonuçları üzerindeki prediktif değerini belirlemektir. Yöntemler: Bu tek merkezli, retrospektif çalışma, kadın hastalıkları ve jinekoloji kliniğimizde teşhis, takip ve doğumları yapılan toplam 8.916 gebeyi kapsamaktadır. Hastalar Hb düzeylerine göre anemik (Hb0,05). Sonuç: Çalışmamızda ilk trimesterde ölçülen Hb konsantrasyonlarına göre ayrılan gruplar arasında olumsuz gebelik sonuçları açısından anlamlı bir farklılık saptanmadı.

The effects of first-trimester hemoglobin on adverse pregnancy outcomes

Aim: Previous studies have demonstrated that variable hemoglobin levels are associated with adverse pregnancy outcomes such as postpartum hemorrhage, pregnancy-induced hypertension, intrauterine growth restriction, gestational diabetes mellitus and perinatal mortality. Here, we aimed to investigate the effects of hemoglobin (Hb) levels measured in the first trimester of pregnancy on pregnancy outcomes and identify the predictive value of Hb on adverse pregnancy outcomes. Methods: This single-center, retrospective study included a total of 8,916 pregnant women who were diagnosed, followed, and delivered their babies in our Obstetrics and Gynecology clinic. The patients were divided into three groups according to their Hb levels as anemic (Hb 0.05 for all). Conclusion: Our study results showed no significant differences between the three groups categorized by Hb concentrations measured in the first trimester in terms of adverse pregnancy outcomes.

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  • 1. Horowitz KM, Ingardia CJ, Borgida AF. Anemia in Pregnancy. Clin Lab Med. 2013;33(2):281-91.
  • 2. Moeller SL, Schmiegelow C, Larsen LG, Nielsen K, Msemo OA, Lusingu JPA, et al. Anemia in Late Pregnancy Induces an Adaptive Response in Fetoplacental Vascularization. Placenta. 2019;80:49-58.
  • 3. Tran K, Mc Cormack S. Screening and Treatment of Obstetric Anemia: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines. Ottawa (ON): CADTH. 2019
  • 4. Global Health Observatory Data Repository. Prevalence of anemia in pregnant women. Estimates by WHO region2018.
  • 5. Smith C, Teng F, Branch E, Chu S, Joseph KS. Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy. Obstet Gynecol. 2019;134:1234–44.
  • 6. Scanlon KS, Yip R, Schieve LA, Cogswell ME. High and low hemoglobin levels during pregnancy: differential risks for preterm birth and SGA. Obstet Gynecol. 2000;96:741–7.
  • 7. Kumar KJ, Asha N, Murthy DS, Sujatha MS, Manjunath VG. Maternal anemia in various trimesters and its effect on newborn weight and maturity: an observational study. Int J Preven Med. 2013;4(2):193-9.
  • 8. Badfar G, Shohani M, SoleymanA, Azami M. Maternal anemia during pregnancy and small for gestational age: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2019;32(10):1728-34.
  • 9. Pena Rozas JB, De-Regil LM, Malave HG, Flores-Urrutia MC, Dowswell T. Intermittent Oral Iron Supplementation During Pregnancy Cochrane Database Syst Rev. 2015;19;2015(10):CD009997.
  • 10. Vural T, Toz E, Ozcan A, Biler A, İleri A, Inan AH. Can anemia predict perinatal outcomes in different stages of pregnancy? Pak J Med Sci. 2016;32:1354-9.
  • 11. Suryanarayana R, Chandrappa M, Santhuram AN, Prathima S, Sheela S R. Prospective study on prevalence of anemia of pregnan two menandits outcome: A community based study. J Family Med Prim Care. 2017;6:739-43.
  • 12. Sacks BD, Arnold B, Bakris GL, Brunns DE, Horward AE, Kirkman SE, et al. Guidelines and recommendations for labaratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem. 2011,57(6):1-47.
  • 13. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, et al. 2013 ESC/ESC guidelines for the management of arteriel hypertension of the European Society of Hpertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34:2159-219.
  • 14. Asıcıoğlu O, Sahbaz A, Gungorduk K, Yıldırım G, Asıcıoğlu BB, Ülker V. Maternal and perinatal outcomes in women with placenta praevia and accreta in teaching hospitals in Western Turkey. J Obstet Gynaecol. 2014;34:462–6.
  • 15. Bencaiova G,Breymann C. Mild Anemia and Pregnancy Outcome in a Swiss Collective. J Pregnancy. 2014;2014:307535.
  • 16. Çakmak BD, Türker ÜA, Öztaş S, Arık M, Üstünyurt E. The effect of first trimester hemoglobin levels on pregnancy outcomes. Turk J Obstet Gynecol. .2018;15:165-70.
  • 17. Randall DA, Patterson JA, Gallimore F, Morris JM, McGee TM, Ford JB, et al. The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes. PLoS ONE. 2019;14(11):e0225123.
  • 18. Hamalainen H, Hakkarainen, K and Heinonen S. Anaemia in the first but not in these condor third trimester is a risk factor for low birth weight. Clinic Nutr. 2003;22(3):271–5.
  • 19. Hercberg S, Preziosi P and Galan P. Iron deficiency in Europe. Public Health Nutr. 2001;4(2B):537–45.
  • 20. Levy A, Fraser D, Katz M, Mazor M, Sheiner E. Maternal anemia during pregnancy is an independent risk factor for low birth weight and preterm delivery. Eur J Obstet Gynecol Reprod Biol. 2005;122:182-6.
  • 21. Sehgal R, Kriplani A, Vanamail P, Maiti L, Kandpal S, Kumar N. Assessment and comparison of pregnancy outcome among anaemic and nonanaemic primigravida mothers. Indian J Public Health. 2016;60:188-94.
  • 22. Wang C, Lin L, Su R, Zhu W, Wei Y, Yan J, et al. Hemoglobin levels during the first trimester of pregnancy are associated with the risk of gestational diabetes mellitus, pre-eclampsia and preterm birth in Chinese women: retrospective study. BMC Pregnancy and Childbirth. 2018;18(1):263.
  • 23. Aghamohammadi A, Zafari M, Tofighi M. High maternal hemoglobin concentration in first trimester as risk factor for pregnancy induced hypertension. Caspian J Intern Med. 2011;2:194-7.
  • 24. Zhu B, Liang C, Xia X, Huang K, Yan S, Hao J et al. Iron-Related Factors in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus: the Ma’anshan Birth Cohort (MABC) Biol Trace Elem Res. 2019;191(1):45-53.
  • 25. Casanueva E, Viteri FE. Iron and oxidative stress in pregnancy. J Nutr 2003;133(2):1700-8.
  • 26. Fernandez-Real JM, Penarroja G, Castro A, Garcia-Bragado F, Hernandez-Aguado I, Ricart W. Blood letting in high ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function. Diabetes. 2002;51(4):1000–4.
  • 27. Gao CJ, Huang XM, Chen ZP, Sheng L, Xu J, Li Y, et al. High Level of Hemoglobin During the First Trimester of Pregnancy Associated With the Risk of Gestational Diabetes Mellitus. Zhonghua Fu Chan KeZaZhi. 2019;54(10):654-9.
  • 28. Pena-Rosas JP, De-Regil LM, Garcia-Casal MN, Dowswell T. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2015;(7).
  • 29. Bakacak M, Avci F,Ercan Ö, Köstü B, Serin S, Kiran G, et al. The effect of maternal hemoglobin concentration on fetal birth weight according to trimesters. J Matern Fetal Neonatal Med. 2015;28(17):2106-10.
Journal of Surgery and Medicine-Cover
  • Başlangıç: 2017
  • Yayıncı: Selçuk BAŞAK
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