KOMUR OCAGINDA ÇALIŞAN İŞÇiLERDE BAZI TUMOR MARKER DUZEYLERiNiN DEGERLENDiRiLMESi

Bu calisma, Kiitahya, Tuncbilek-Omerler yeraltt komurocagtnda caltsan 36-45 yaslart arastnda (x =36,27) 29 erkek isci ilesigara ve alkol kullanmayan 23-53 yaslart arastnda (x =36,52) 36sagltkl: erkek buro memurlart uzerinde gerceklestirildi. lkinci grupkontrol grubu olarak degerlendirildi.CEA ve AFP duzeylerinin tayini RIA metoduyla, diger tayinlerise (ALP, ACP, Total protein ve albumin) spektroJotometrik metotlarlayapildt. Butun analizler hem isci hem de memurlartn serum numunelerindegerceklestirildi.Sonuc olarak; ACP, AFP, ALP ve CEA (tumor markerleri)duzeyleri iscilerde kontrollerinkinden onemli derecede yuksek bulundu(strastyla p< 0.0001 ve p< 0.005). Diger taraftan iscilerde total proteinduzeyleri dusuk (p< O.025) fakat albumin duzeyleri kontro/ grubunagore bilakis yuksek bulundu. Bu sonuclardan komur ocagtndakikomur tozlart, kimyasal maddeler ve ortamtn iscilerin organ/art uzerindeolumsuz etkilere sahip oldugu dusunuldu.

Anahtar Kelimeler:

Tumor markerleri, isciler, komur madeni

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