Govind ARORA, Inderbir SINGH, Bhawna SHARMA

Application of SeDeM expert system in formulation and development of fast disintegrating tablets using starchglycine conjugates as superdisintegrant

In the present study, microwave assisted synthesis of starch and glycine (1:1, 1:3, 1:5) conjugates was performed for its application as tablet superdisintegrant. Chemical interactions between starch and glycine were studied by FTIR analysis. Scanning electron microscopy (SEM) was performed to study the surface morphology of conjugates. An innovative tool, SeDeM expert system, was employed to provide index for good compressibility (IGCD) and dispersibility (IGD) against the parameters for the powder under study. IGCD mainly comprises of six main factors (derived from 15 practical pharmaceutical range factors) they initially indicate whether powder has the ability to undergo the process direct compression. IGD (derived from 3 factors) indicates whether the tablets formulated using the given powders are suitable to be used fast disintegrating tablet formulations. SeDeM expert system is an innovative tool for assessing direct compression suitability materials and disintegration potential of the tablets. Optimum ratio of starch and glycine was found to be 1:5 with the IGCD score of 6.4 which was comparatively much better than the other selected ratio’s.

PDF

___

Sipos E, Oltean AR, Szabó ZI, Rédai EM, Nagy GD. Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets. Acta Pharm. 2017; 67(2): 237-246. [CrossRef]
Aguilar JE, Garcia E, Suñe JM, Perez P, Miñarro M, Tico JR. Predicting orally disintegrating tablets formulations of ibuprophen tablets: An application of the new SeDeM-ODT expert system. Eur J Pharm Biopharm. 2012; 80(3): 638648. [CrossRef]
Singh I, Kumar P. Preformulation studies for direct compression suitability of cefuroxime axetil and paracetamol: A graphical representation using SeDeM diagram. Acta Pol Pharm. 2012; 69(1): 87-93.
Juneja P, Kaur B, Odeku OA, Singh I. Development of corn Starch-Neusilin UFL2 conjugates as tablet superdisintegrant: Formulation & evaluation of fast disintegrating tablets. J Drug Deliv. 2014; 827035. [CrossRef]
Rashid M, Al-Remawi, Leharne SA, Chowdhry BZ, Badwan A. A novel multifunctional pharmaceutical excipient: modification of the permeability of starch by processing with magnesium silicate. Int J Pharm. 2011; 411(1-2): 18-26. [CrossRef]
Singh A, Singh A, Nath LK. Microwave assisted synthesis and evaluation of modified pea starch as tablet superdisintegrant. Curr Drug Del. 2011; 8(2): 203-207. [CrossRef]
Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EM, McCallum R, Leidy NK, Farup C, Liu Y, Joslyn A. Domperidone in the management of symptoms of diabetic gastroparesis: Efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. Clin Ther. 1998; 20: 438-453. [CrossRef]
Khan A, Iqbal Z, Rehman Z, Nasir F, Khan A, Ismail M, RoohullahMohammad A. Application of SeDeM expert system in formulation development of effervescent tablets by direct compression. Saudi Pharm J. 2014; 22(5): 433444. [CrossRef]
Goel H, Vora N, Tiwary AK, Rana V. Formulation of orodispersible tablets of ondansetron HCl: Investigations using glycine-chitosan mixture as superdisintegrant. YakugakuZasshi. 2009; 129(5): 513-521. [CrossRef]
Singh I, Kaur B, Juneja P. Preparation and characterization of starch-metal silicate Co-precipitates--evaluation as tablet superdisintegrant. Polim Med. 2014; 44(3): 157-166.
Nagpal M, Goyal A, Kumar S, Singh I. Starch-silicon dioxide coprecipitate as superdisintegrant: Formulation and evaluation of fast disintegrating tablets. Int J Drug Delivery. 2012; 4(2): 164-174.
Fini V, Bergamante GC, Ceschel C, Ronchi, Moraes CA. Fast dispersible/slow releasing ibuprofen tablets. Eur J Pharm Biopharm. 2008; 69(1): 335-341. [CrossRef]
Patel DM, Patel SP, Patel CN. Formulation and evaluation of fast dissolving tablet containing domperidone ternary solid dispersion. Int J Pharm Investig. 2014; 4(4): 174-182.