Formulation and in vitro evaluation of superporous hydrogel based gastroretentive drug delivery system of vildagliptin
Formulation and in vitro evaluation of superporous hydrogel based gastroretentive drug delivery system of vildagliptin
Numerous medications, which have a tight restorative window and are consumed predominantly in thestomach have been created as a gastroretentive conveyance framework. Vildagliptin, an antidiabetic, is exceedinglytemperamental at fundamental pH and is widely retained from the stomach. Henceforth there is a need to build up agastroretentive framework. In this investigation a superporous hydrogel was created as a gastroretentive medicationconveyance framework. Superporous hydrogels were readied utilizing a gas forming method utilizing N', N'- BIS asthe crosslinking operator and polyvinyl Alcohol as a composite specialist. Swelling practices of the superporoushydrogel in acidic arrangement were concentrated to explore their applications for gastric maintenance gadget. Theideal arrangement state of superporous hydrogels was gotten from the swelling and in vitro medication discharge thinksabout. FT-IR, SEM and DSC contemplates were utilized to portray the similarity between polymers. As the grouping ofcrosslinker expanded from 0.5 to 3% the porosities diminished. In reenacted gastric liquid superporous hydrogelsdemonstrated a decent increment in harmony swelling limit. Checking electron infinitesimal pictures plainly showedthe arrangement of interconnected pore and slim channels. Portrayal thinks about uncovered that the expansion incrosslinker focus is beneficial from the swelling proportion, and yet the decline in porosity may prompt abatement inmedication discharge rate by dispersion through these narrow channels. The medication discharge from superporoushydrogels appeared for a drawn out timeframe. Structure the discharge energy it uncovered that sedate pursues theNon – Fickian mechanism. FTIR and DSC ponders uncovered that there were no critical collaborations between thedrug and polymers. In light of the portrayal thinks about, it was uncovered that superporous hydrogels could be utilizedas a gastroretentive medication conveyance framework for vildagliptin in perspective on their swelling and delayedmedication discharge qualities in acidic pH.
___
- [1] Ichikawa M, Kato T, Kawahara M, Watanabe S, Kayano M. A New Multiple-Unit Oral Floating Dosage System - In- Vivo Evaluation of Floating and Sustained-Release Characteristics with P-Amino Benzoic Acid and Isosorbide Dinitrate as Model Drugs. J Pharm Sci. 1991; 80(12): 1153-1156. [CrossRef]
- [2] Leung SH, Trans BK, Robinson JR. Polyanionic Hydrogel as A Gastric Retention System. J Biomater Sci Polym Ed. 1993; 4(5): 483-492. [CrossRef]
- [3] Stops F, Fell JT, Collett JH, Martini LG. Floating Dosage Forms to Prolong Gastro-RetentionThe Characterisation of Calcium Alginate Beads. Int J Pharm. 2008; 350(12): 301-311. [CrossRef]
- [4] Praveen K S, Gayathri S A, Abhay A. Formulation development and Evaluation of Hydrogel Based Gastroretentive Drug Delivery System of AntiHypertensive Drug. In J Pharm Clin Res. 2016; 8(10): 1396-1401.
- [5] Pratley RE, Afshin S, Glenn M. Review: Inhibition of dipeptidyl peptidase-4 with vildagliptin: a potential new treatment for type 2diabetes. Br J Diabetes Vasc Dis 2006; 6(4): 150-156.
- [6] https://www.aace.com/files/dm-guidelines-ccp.pdf. (accessed December 9, 2018)
- [7] Priyanka S, Shiva Kumar B, Ashraful Islam SM, Selim Raza Md, Santosh Adhikari. Design and Development of Immediate and Sustained Release tablets of Vildagliptin. Res J Pharm Biol Chem Sci. 2014; 5(4): 811-825.
- [8] Vergnaud JM. Controlled drug release from oral dosage forms, Ellis Horwood Limited, London, 1993.
- [9] Chien YW. Novel drug delivery systems, Second ed., Marcel Dekker, Inc., New York, 1992.
- [10] Ahrén, B; Landin-Olsson, M, Jansson, PA, Svensson, M, Holmes, D, Schweizer, A. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. J. Clin. Endocrinol. Metab. 2004; 89(5): 2078–84. [CrossRef]
- [11] Mentlein, R; Gallwitz, B; Schmidt, WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur. J. Biochem. 1993; 214(3): 829–35. [CrossRef]
- [12] Manish Kumar Singh, Pramod Kumar Sharma, Nitin Sharma. Gastroretentive Drug Delivery System based On Natural Mucoadhesive Polymer. J Pharm Res. 2011; 4(2): 519-21.
- [13] Desu PK, Rao PV and Kotra V. Synthesis and characterization of PVA based poly (acrylic acid-co-acrylamide) superporous hydrogels composites. Int J Pharm Sci Res. 2018; 9(10): 4361-67. [CrossRef]
- [14] Dorkoosh FA, Brussee J, Verhoef JC, Borchard G, RafieeTehrani M, Junginger HE. Preparation and NMR characterization of superporous hydrogels and Superporous hydrogel composites. Polymer. 2000; 41(23): 8213–8220. [CrossRef]
- [15] Kumar KA, Reddy MS, Manohara P, Babu PS. A review on gastro-retentive superporous hydrogels and its generations. Journal of Chemical and Pharmaceutical Sciences. 2012; 5(2): 78-81.
- [16] Chavda HV, Patel CN, Karen HD. Preparation and characterization of chitosan-based superporous hydrogel composite. J Young Pharm. 2009; 1(3): 199-204.
- [17] Bagadiya A, Kapadiya M, Mehta K. Superporous hydrogel: a promising tool for gastro retentive drug delivery system. In J pharm Tech. 2011; 3(4): 1556-1571. [CrossRef]
- [18] Pati NB, Velivela S, Mayasa V, Gupta VRM. Gastroretentive superporous hydrogel tablets of dexlansoprazole. Int J Pharm Sci Res 2016; 7(11): 4678-4685. [CrossRef]
- [19] S. Dineshmohan, G. Roja, Y. Harika, R. Harika, V. R. M. Gupta. Effect of Hydrophilic and Hydrophobic Polymer Combinations in Vildagliptin Sustained Release Tablets: Fabrication and In Vitro Characterization. Asian J. Pharm 2015; 9(4): 298-306.
- [20] Hixon AW, Crowell JH. Dependence of reaction velocity upon surface and Agitation. Indus Eng Chem. 1931; 23(10): 923-31. [CrossRef]
- [21] Korsmeyer RW, Gurny R, Doelker E. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983; 15(1): 25-35. [CrossRef]
- [22] Gupta VN, Shiva Kumar GH. Investigation of swelling behaviour and mechanical properties of a pH-sensitive superporous hydrogel composite. Iran J Pharm Res. 2012; 11(2): 481-493.
- [23] Ray D, Sahoo PK, Mohanta GP. Designing of superporous cross-linked hydrogels containing acrylic-based polymer network. Asian J. Pharm. 2008; 2(2):123127.
- [24] Santosh R. Tambe1, Leena P. Deore Devidas G. Bachhav. Formulation Development and Characterization of Superporous Hydrogel of Itopride Hydrochloride for Gastroretentive Drug Delivery System. W J Pharm Res. 2015; 4(2): 1552-1573.