Successful salvage treatment of Lecythophora mutabilis keratitis with topical voriconazole
Successful salvage treatment of Lecythophora mutabilis keratitis with topical voriconazole
Fungal keratitis is an important ophthalmic problem in the developing world. Filamentous fungi are the most frequently reported pathogens in fungal keratitis. This report aimed to present a case with Lecythophora mutabilis keratitis that treatment failure was seen with topical and systemic amphotericin B lipid complex. Then she was treated successfully topical voriconazole.
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- Al-Badriyeh D, Neoh CF, Stewart K, Kong DC.. Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis. Clin Ophthalmol 2010; 4: 391-405.
- Hariprasad SM, Mieler WF, Lin TK, Sponsel WE, Graybill JR. Voriconazole in the treatment of fungal eye infections: A review of current literature. Br J Ophthalmol 2008; 92:871– 878.
- Fintelmann RE, Gilmer W, Bloomer MM, Jeng BH. Recur- rent Lecythophora mutabilis keratitis and endophthalmitis after deep anterior lamellar keratoplasty. Arch Ophthalmol. 2011;129:108-110.
- Marcus DM, Hull DS, Rubin RM, Newman CL. Lecythophora mutabilis endophthalmitis after long-term corneal cyanoacry- late. Retina. 1999;19:351-353.
- Scott IU, Cruz-Villegas V, Flynn HW Jr, Miller D. Delayed-on- set, bleb-associated endophthalmitis caused by Lecythopho- ra mutabilis. Am J Ophthalmol 2004;137:583-585.
- Riddell J, Comer GM, Kauffman CA. Treatment of endogenous fungal endophthalmitis: focus on new antifungal agents. Clin Infect Dis 2011; 52:648-653.
- Goldblum D, Frueh BE, Zimmerli S, Böhnke M. Treatment of post-keratitis Fusarium endophthalmitis with amphotericin B lipid complex. Cornea 2000; 19:853-857.
- Virata SR, Kylstra JA, Brown JC, Wohl DA, Cohen MS. Wors- ening of endogenous Candida albicans endophthalmitis dur- ing therapy with intravenous lipid complex amphotericin B. Clin Infect Dis 1999; 28:1177-1178.
- Al-Badriyeh D, Leung L, Davies GE, Stewart K, Kong D. Suc- cessful use of topical voriconazole 1% alone as first-line antifungal therapy against Candida albicans keratitis. Ann Pharmacother 2009;43: 2103-2107.
- Dupuis A, Tournier N, Le Moal G, Venisse N. Preparation and stability of voriconazole eye drop solution. Antimicrob Agents Chemother. 2009; 53:798–799.
- Lau D, Ferdinands M, Leung L, et al. Penetration of voricon- azole 1% eyedrops into human aqueous humor. A prospec- tive open label study. Arch Ophthalmol 2008; 126: 343-346.