The relationship between myocardial viability and plasma NT-proBNP levels

Aim: There is no biochemical marker that indicates myocardial viability in the late phase after myocardial infarction. The aim of our study was to identify whether plasma NT-proBNP levels indicate the presence of viable myocardium after myocardial infarction. Material and Methods: Patients with myocardial infarction and left ventricular ejection fraction of less than 45% were included in the study. Exercise or pharmacological myocardial perfusion scintigraphy was performed to investigate viability in the infarction region. The left ventricle was divided into 19 segments where the necrotic area and viable myocardium within it was measured. Blood samples for NT-proBNP measurement were obtained from all patients on the same day scintigraphy performed. Results: A total of 60 patients were included in the study (10 females, 50 males, mean age 62 ± 9 years). 48 (80%) patients underwent exercise scintigraphy. The mean exercise time was 7.1 ± 2.3 minutes. The infarct area was located in anterior segments in 16 patients, inferior in 25, and in both locations in 19 patients. The mean left ventricular ejection fraction was 36 ± 8%. There was a negative correlation between left ventricular ejection fraction and serum NT-proBNP levels (r = -0.03 p <0.01). On the other hand, there was no correlation between plasma NT-proBNP levels and the presence or extent of viable myocardium within the necrotic area (P = 0.8). Conclusion: There was no correlation between plasma NT-proBNP levels and the presence of viable myocardium in the infarct zone in patients with myocardial infarction

Keywords:

myocardial infarction, viable myocardium NT-proBNP,

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