___

• KAYNAKLAR 1- Kim D,Zeng MY et al. The interplay between host immune cells and gut micorbiota in chronic inflammatory diseases. Experimental and molecular medicine 2017;49.
• 2- Konturek P C,Hazırı D ,Brzozowskı T et al. Emerging role of fecal microbiota therapy in the treatment of gastrointestinal and extragastrointestinal diseases. Journal of physiology and pharmacology 2015,66,4,483-491.
• 3- EckburgPB, et al. Diversity of the human intestinal micorbial flora. Science 2005;308:1635-38.
• 4- Frank DN et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatroy bowel diseases. Proc Natl Acad Sci. USA. 2007;104:13780-85.
• 5- Stout MJ et al. Identification of intracelluler bacterial in the basal plate of human placenta in term and preterm gestations. Am J Obstet. Gynecol. 2013;208-226.
• 6- Jimenez E et al. Is meconium from healty newborns actual sterile? Res microbiol 2008;159:187-9.
• 7- Gueimonde M, Sakata S,et al. Effect of maternal consumption of lactobacillus GG on transfer and establishment of fecal bifidobacterial microbiota in neonates. J Pediatr Gastroenterol Nutr 2006; 42:166–70.
• 8- Vaishampayan PA, Kuehl JV, et al.Comparative metagenomics and population dynamics of the gut microbiota in mother and infant. Genome Biol Evol 2010; 2:53–66.
• 9- Penders J, Thijs C, Vink C et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006; 118:511–21.
• 10- Dominguez-Bello MG, Costello EK, Contreras M et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 2010; 107:11971–5.
• 11- Nelun Barfod M, Magnusson K,et al. Oral microflora in infants delivered vaginally and by caesarean section. Int J Paediatr Dent 2011; 21:401–6.
• 12- Kinross J, Nicholson JK. Gut microbiota: dietary and social modulation of gut microbiota in the elderly. Nat Rev Gastroenterol Hepatol 2012; 9:563–4.
• 13- Claesson MJ, Cusack S, O’Sullivan O et al. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci USA 2011; 108 (Suppl. 1):4586–91.
• 14- Toward R, Montandon S, Walton G, Gibson GR. Effect of prebiotics on the human gut microbiota of elderly persons. Gut Microbes 2012; 3:57–60.
• 15- CT Peterson,V Sharma et al. Immune homeostasis,dysbiosis and therapotic modulation of gut microbiata. Clinical Exp Immunology 2014; 363-77.
• 16- Altuntaş Y,Batman A. Mikrobiata ve metabolik sendrom.Türk Kardiyoloji Derneği Ars 2017;45(3): 286-96.
• 17- Al-lahhamSH, Peppelenbosch MP et al. Biological effects of propionic acid in humans;metabolism potential applications and underlying mechanisms.Biochim Biophys Acta 2010;1801:1175-83
• 18- Heerdt BG et al. Short chain fatty acid initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function. Cell Growth Differ 1997;8:523-532
• 19- Bercik P collins Sm et al. Microbes and the gut-brain axis. Neurogastroenterol Motil 2012;24:405-13.
• 20- Konturek PC et al. Stress and the gut:pathophysiology clinical consequences,diagnostic approach and treatment options.Jphysiol Pharmacol 2011;62:591-99.
• 21- Szabo G. Gut liver axis in alcoholic liver disease.Gastroenterology 2015;148:30-36
• 22- Czepiel J, Biesiada G, Brzozowski T, et al. The role of local and systemic cytokines in patients infected with Clostridium difficile. J Physiol Pharmacol 2014; 65: 695-703.
• 23- Bouza E. Consequences of Clostridium difficile infection: understanding the healthcare burden. Clin Microbiol Infect 2012; 18 (Suppl. 6): 5-12.
• 24- Tacke D, Wisplinghoff H, Kretzschmar A, et al. First implementation of frozen, capsulized faecal microbiota transplantation for recurrent Clostridium difficile infection into clinical practice in Europe. Clin Microbiol Infect 2015; Jul 7: S1198-743X(15)00689-8.
• 25- Eiseman B, Silen W, Bascom CS, Kauvar AJ. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery 1958; 44: 854-859.
• 26- Van Nood E et al .Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013;368:407–415.
• 27- Kelly CR, Ihunnah C, Fischer M, et al. Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients. Am J Gastroenterol 2014;109: 1065-1071.
• 28- Çelebi G, Uygun A. İntestinal mikrobata ve fekal transplantasyon. Güncel Gastroenteroloji 2017 ;2:148-157.
• 29- Matsuoka K,Kanai T. The gut mikrobiota and inflammatory bowel disease. Semin İmmunopathol. 2015;37:47-55.
• 30- Takaishi H et al (2008) Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease. Int J Med Microbiol 298:463–472.
• 31- Pitcher MC et al .The contribution of sulphate reducing bac- teria and 5-aminosalicylic acid to faecal sulphide in patients with ulcerative colitis. Gut 2000; 46:64–72.
• 32- Colman RJ, Rubin DT. Fecal microbiota transplantation as therapy for inflammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis 2014; 8: 1569-1581.
• 33- Gevers D et al The treatment-naive microbiome in new-onset Crohn’s disease. Cell Host Microbe 2014; 15:382–392.
• 34- Dylag K, Hubalewska-Mazgaj M,et al. Probiotics in the mechanism of protection against gut inflammation and therapy of gastrointestinal disorders. Curr Pharm Des 2014; 20: 1149-1155.
• 35- Shanahan F, Quigley EM. Manipulation of the microbiota for treatment of IBS and IBD-challenges and controversies. Gastroenterology 2014; 146: 1554-1563.
• 36- Ringel Y, Maharshak N. Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2013; 305: G529-G541.
• 37- Festi D,Schiumerini R et al. Gut microbiota and metabolic syndrome.World Journal of Gastroenterology 2014:21;20(43):16079-94.
• 38- Harststra AV,Bouter K. Et al .Insights in to The Role of The Microbioma in Obesity and Type 2 Diabetes .Diabetes Care 2015;38:159-165.
• 39- Sanacruz A,Collado MC et al. Gut microbiota composition is associated with body weight gain and bipochemical parameters in pregnant women. Br J Nutr 2010;104:83-92.
• 40- Penders J, Thijs C et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006;118:511-21.
• 41- Turnbaugh PJ,Backhed F et al . Diet induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome.Cell Host Microbe 2008;3:213-223.
• 42- Hildebrandt MA,Hoffmann C et al. High fat diet determines the composition of the murine gut micorbiome independently of obesity. Gastroenterology 2009;137:1716-24.
• 43- De Filippo C, Cavalieri D et al. Impact of diet in shaping gut micorbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 2010;107:14691-96.
• 44- Brinkworth GD,Noakes M et al Comparative effects of very low charbonhydrate ,high fat and high carbonhydrate,low fat weight loss diets on bowel habit and faecal short chain fatty acids and bacterial populations. Br J Nutr. 2009;101:1493-1502.
• 45- Cani PD,amar J et al .Metabolic endotoxemia initiates obesity and insülin resistance. Diabetes 2007;56:1761-1772
• 46- Lam YY,Ha CW et al. Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfonction in diet induced obese mice. PLoS One 2012;7:e34233
• 47- Liou AP, Paziuk M, Luevano J-M,et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med 2013; 5:178ra41
• 48- Furet J-P, Kong L-C, Tap J, et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with meta- bolic and low-grade inflammation markers. Diabetes 2010;59:3049–3057.
• 49- Zhang H, DiBaise JK, Zuccolo A, et al. Human gut microbiota in obesity and after gastric by- pass. Proc Natl Acad Sci U S A 2009;106:2365– 2370.
• 50- Fei N,Zhao L. An opportunistic pathogen isolated from the gut of an obese human causes obesity in germ free mice. ISME J 2013;7:880-84.
• 51- Backhed F,Ding H et al. The gut microbiata as an environmental factor that regülates fat storage. Proc Natl Acad Sci USA 2004;101:15718-23.
• 52- Le Chatelier E,Nielsen T,Qin J et al. Richness of human gut microbiome correlates with metabolic markers. Nature 2013;500:541-46.
• 53- Kalliomaki M,Collado MC et al. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr 2008;87:534-38.
• 54- Karlsson CL, Onnerfalt J et al.The microbiota of the gut in preschool children with normal and excessive body weight. Obesity (silver Spring) 2012;20:2257-2261.
• 55- Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with nor- mal, impaired and diabetic glucose control. Na- ture 2013;498:99–103.
• 56- Qin J, Li Y, Cai Z, et al. A metagenome wide association study of gut microbiota in type 2 diabetes. Nature 2012;490:55–60.
• 57- Zhang X,Shen D,Fang Z et al. Human gut microbiota changesreveal te progression of glucose intolerance. Plos One 2013;8:e71108.
• 58- Wu X,Ma C et al.molecular characterisationfo the faecalmicrobiota in patients with type 2 diabetes. Curr Microbiol 2010;61:69-78.
• 59- Vrieze A,Van Nood E et al.Transfer of intestinal microbiota from lean donors increases insulin sensitivity iin indivituals with metabolic syndrome.Gastroenterology 2012;143:913-16.
• 60- Membrez M,Blancher F et al gut microbiota modulation with norfloksaxin and ampicillin enhances glucose tolerance in mice. FASEB J 2008;22:2416-26.
• 61- Amar J,Serino M et al. Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept.Diabetologia 2011;54:3055-61.
• 62- Creely SJ,McTernan PG et al.Lipopolisaccaride activates an innate immune system response in human adipose tissuein obesity and type 2 diabetes. Am JPhysiol Endocrinol Metab 2007;292:E740-47.
• 63- Rivera CA, Adegboyega P,Van Rooijen N et al.Toll like receptor 4 signaling and Kuppfer cellsplay pivotal roles inthe pathogenesis of non-alcoholic steatohepatitis.J Hepatology 2007;47:571-79.
• 64- Karlsson FH, Tremaroli V et al.Gut metagenomein eutropean womenwith normal,impaired and diabetic glucose control.Nature 2013;498:99-103.
• 65- Spruss A,Kanuri G et alToll like receptor 4 is involved in the develpment of fructose –induced hepatic steatosis in mice. Hepatology 2009;50:1094-1104.
• 66- Miele L,Valenza V et al increased intestinal permeability and tight junction alterations in nonlcoholic fatty liver disease. Hepatology 2009;49:1877-87.
• 67- Mouzaki M,Comelli EM et al intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology 2013;58:120-7.
• 68- Zhu L,Baker SS et al.Characterisation of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients:a connection between endogenous alcohol and NASH. Hepatology 2013;57:601-9.
• 69- Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299: 1259–1260
• 70- Ownby DR, Johnson C, Peterson EL. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA 2002; 288: 963–972.
• 71- Riedler J, Braun-Fahrlander C, Eder W, Schreuer M, Waser M, Maisch S et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358: 1129–1133.
• 72- Guaraldi F, Salvatori G. Effect of breast and formula feeding on gut microbiota shaping in newborns. Front Cell Infect Microbiol 2012; 2: 94
• 73- Abrahamsson TR, Jakobsson HE, et al.Jenmalm MC. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy 2014; 44: 842–850
• 74- Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 2010; 107: 11971–11975.
• 75- Renz-Polster H, David MR, et al. Caesarean section delivery and the risk of allergic disorders in childhood. Clin Exp Allergy 2005; 35: 1466–1472.
• 76- Russell SL, Gold MJ, Hartmann M, et al. Early life antibiotic-driven changes in microbiota enhance suscept- ibility to allergic asthma. EMBO Rep 2012; 13: 440–447.
• 77- Stensballe LG, Simonsen J,et al. Use of antibiotics during pregnancy increases the risk of asthma in early child- hood. J Pediatr 2013; 162: 832–838.e833.
• 78- Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014; 20: 159–166.
• 79- Chen J, Wright K, Davis JM, et al. An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. Genome Med 2016; 8: 43.
• 80- Zhang X, Zhang D, Jia H. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med 2015; 21: 895–905.
• 81- Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife 2013; 2: e01202.
• 82- Gill T,Asquitf M et al. The intestinal microbiome in spondyloarthritis. Curr Opin Rheumatol.2015 July;27(4):319-25.
• 83- Nagalingam NA, Kao JY, Young VB. Microbial ecology of the murine gut associated with the development of dextran sodium sulfate induced colitis. Inflamm Bowel Dis. 2011; 17:917–926.
• 84- Ebringer R, Cooke D, Cawdell DR et al. Ankylosing spondylitis: klebsiella and HL-A B27. Rheumatol Rehabil. 1977; 16:190–196.
• 85- Tani Y, Tiwana H, Hukuda S et al. A. Antibodies to Klebsiella, Proteus, and HLA-B27 peptides in Japanese patients with ankylosing spondylitis and rheumatoid arthritis. J Rheumatol. 1997; 24:109–114.
• 86- Stoll ML, Kumar R, et al.Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis. Arthritis Res Ther. 2014; 16:486.
• 87- Stebbings S, Munro K, et al. Comparison of the faecal microflora of patients with ankylosing spondylitis and controls using molecular methods of analysis. Rheumatology (Oxford). 2002; 41:1395–1401.
• 88- Willing BP, Dicksved J et al.A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology. 2010; 139:1844– 1854. e1841.
• 89- de Silva HJ, Millard PR, Soper N, Kettlewell M, Mortensen N, Jewell DP. Effects of the faecal stream and stasis on the ileal pouch mucosa. Gut 1991; 32: 1166-1169
• 90- Mangiola F,Ianiro G, et al. Gut microbiota in autizm and mood disorders.World Gastroenterol 2016; J 7;22(1):361-68.
• 91- Rhee SH, Pothoulakis C, Mayer EA. Principles and clinical implications of the brain-gut-enteric Nat Rev Gastroenterol Hepatol microbiota axis. 2009; 6: 306-314.
• 92- Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012; 13: 701-712.
• 93- O’Mahony SM, Marchesi JR,et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry 2009; 65: 263-267 [PMID: 1872316
• 94- Finegold SM, Molitoris D, Song Yet al.Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis 2002; 35: S6-S16 .
• 95- Song Y, Liu C, Finegold SM. Real-time PCR quantitation of clostridia in feces of autistic children. Appl Environ Microbiol 2004; 70: 6459-6465.
• 96- Parracho HM, Bingham MO, Gibson GR, McCartney AL. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol 2005; 54: 987-991 [PMID: 16157555
• 97- Bolte ER. Autism and Clostridium tetani. Med Hypotheses 1998; 51: 133-144.
• 98- Sandler RH, Finegold SM, et al.Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol 2000; 15: 429-435
• 99- Emanuele E, Orsi P,et al. Low-grade endotoxemia in patients with severe autism. Neurosci Lett 2010; 471: 162-165.
• 100- Evrensel A,Ceylan ME. Fecal microbiata transplantation and its usage in neurophysiatric disorders. Clinical phychopharmacology and neuroscience 2016;14(3):231-37.
• 101- Aroniadis OC, Brandt LJ. Fecal microbiota transplantation: past, present and future. Curr Opin Gastroenterol 2013;29:79-84
• 102- Gondalia SV,Palombo EA ,Knowles SR et al. Molecular characterization of gastrointestinal microbiota of children with autism (with or without gastrointestinal dysfunction) and their nörotypical siblings.Autism Res 2012;5:419427.
• 103- Schab DW, Trinh NH. Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta-analysis of double-blind placebo-controlled trials. J Dev Behav Pediatr. 2004; 25(6):423–434.
• 104- Jiang H, Ling Z, Zhang Y et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun 2015; 48: 186-194. 105- Khanna S, Pardi DS. The growing incidence and severity of Clostridium difficile infection in inpatient and outpatient settings. Expert Rev Gastroenterol Hepatol 2010; 4: 409-416.
• 106- Ait-Belgnaoui A, Durand H, Cartier C,et al. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats.Physchoneuroendocrinology 2012:37:1885-95.
• 107- Desbonnet L, Clarke G,et al. Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour. Brain Behav Immun 2015; 48: 165-173. 108- Soczynska JK, Mansur RB, et al.Novel therapeutic targets in depression: minocycline as a candidate treatment. Behav Brain Res 2012; 235: 302-317.
• 109- Miyaoka T, Wake R, Furuya M,et al. Minocycline as adjunctive therapy for patients with unipolar psychotic depression: an open-label study. Prog Neuropsychopharmacol Biol Psychiatry 2012; 37: 222-226.
• 110- Nigg JT, Lewis K, Edinger T, Falk M. Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry. 2012; 51(1):86–97.
• 111- Grigoleit JS, Kullmann JS, Wolf OT,et al. Dose-dependent effects of endotoxin on neurobehavioral functions in humans. PLoS One 2011; 6: e28330 .
• 112- Naseribafrouei A, Hestad K, Avershina E, et al.Between the human fecal microbiota and depression. Neurogastroenterol Motil 2014; 26: 1155-1162.
• 113- Jiang H,Ling Z,Zhang Y et al.altered fecal microbiata composition in patients with major depressive disorder.Brain Behav Immun 2015;48:186-194.
• 114- Neufeld KM, Kang N, Bienenstock J, Foster JA. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 2011; 23: 255-264.
• 115- Clarke G, Grenham S, Scully P, et al.The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 2013; 18: 666-673.
• 116- Logan AC, Katzman M. Major depressive disorder: probiotics maybe an adjuvant therapy. Med Hypotheses 2005; 64: 533-538.
• 117- Berer K, Mues M, Koutrolos M, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011; 479(7374):538–541.
• 118- Theoharides TC, Enakuaa S, Sismanopoulos N, et al. Contribution of stress to asthma worsening through mast cell activation. Ann Allergy Asthma Immunol. 2012; 109(1):14–19.
• 119- Chandler N, Jacobson S, Connolly R, Esposito P, Theoharides TC. Acute stress shortens the time of onset of experimental allergic encephalomyelitis (EAE) in SJL/J mice. Brain Behav Immun. 2002; 16:757–763.
• 120- Tache Y, Martinez V, Million M, Wang L. Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am J Physiol Gastrointest Liver Physiol. 2001; 280(2):G173–G177.
• 121- Gur TL, Worly BL, Bailey MT. Stress and the commensal microbiota: importance in parturition and infant neurodevelopment. Front Psychiatry. 2015; 6:5.
• 122- Piccio L, Stark JL, Cross AH. Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis. J Leukoc Biol. 2008; 84(4):940–948.
• 123- Mulak A,Bonaz B et al;Brain-gut microbiata axis in Parkinson’s Disease. World J Gastroenterol. 2015 oct 7;21(37):10609-620.
• 124- Xu MQ, Cao HL, Wang WQ, Wang S, Cao XC, Yan F, et al. Fecal microbiota transplantation broadening its applica- tion beyond intestinal disorders. World J Gastroenterol 2015;21:102-111.
• 125- Vizcarra JA, Wilson-Perez HE, Espay AJ. The power in numbers: gut microbiota in Parkinson’s disease. Mov Disord 2015; 30: 296-298.
• 126- Sui YT, Bullock KM, Erickson MA, Zhang J, Banks WA. Alpha synuclein is transported into and out of the brain by the blood-brain barrier. Peptides 2014; 62: 197-202.
• 127- Ananthaswamy A. Faecal transplant eases symptoms of Parkinson’s disease. New Sci 2011;209:8-9.
• 128- Scheperjans F, Aho V, Pereira PA, et al.Gut microbiota are related to Parkinson’ s disease and clinical phenotype. Mov Disord 2015; 30: 350-358.
• 129- Hill J M,Bhattacharjee S et al . The Gastrointestinal tract microbiome and potential link to Alzheimer’s Disease.Frontiers in Neurology 2014 .4;5:43.
• 130- Albenberg LG, Wu GD. Diet and the intestinal microbiome: associations, functions, and impli- cations for health and disease. Gastroenterology (2014). doi:10.1053/j.gastro.2014.01.058
• 131- Schwartz K, Boles BR. Microbial amyloids-functions and interactions within the host. Curr Opin Microbiol (2013) 16:93–9
• 132- Asti A, Gioglio L. Can a bacterial endotoxin be a key factor in the kinetics of amyloid fibril formation? J Alzheimers Dis (2014) 39:169–79.
• 133- Li J,Lee DS et al Evolving bacterial envelopes and plasticity of TLR-2-dependent responses: Basic research and translational opportunities. Front Immunol 4,347. 134- Smith MA, Perry G et al Oxidative damage in Alzheimer’s. Nature 382,120-121.