Derya ŞAHİN, Semih BAŞÇI, Ayşe TEMİZEL, Hikmetullah BATGİ, Bahar UNCU ULU, Nuran Ahu BAYSAL, Dicle İSKENDER, Merih KIZIL ÇAKIR, Sinan DAL, Fevzi ALTUNTAŞ

The relationship between blood groups and acute myeloid leukemia

Aim: Acute myeloid leukemia is an aggressive disease caused by a heterogeneous clonal disorder of hematopoietic progenitor cells that normally lose their ability to respond to differentiation and proliferation regulators. The main purpose is to identify and prevent the causes of acute leukemia. Although the etiology of acute leukemia has been investigated for many years, the exact cause is still unknown. Both ABO and Rh blood group systems have been associated with a number of diseases. The aim of this study was to investigate the relationship between AML and blood group types. Material and Method: Between February 2014 and February 2018 The blood types of 163 AML patients treated in Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital were analyzed retrospectively. Age, sex, and blood group data of healthy platelet donors were used as a control group. Results: The most common blood type in both men and women was A Rh-positive, no statistically significant difference was found between the control group and AML patients in terms of ABO blood group distribution. Rh positivity rate was similar between the patient group and healthy control group. Discussion: We found that there is no relation between AML and ABO and Rh blood groups. Although there are larger studies confirming the relationship between solid tumors and ABO blood groups, studies on hematologic malignancies are fewer. Cunclusion: A relationship between AML and ABO and Rh blood groups has not yet been clarified, more studies with more patients are needed.

Keywords:

Blood group types, acute myeloid leukemia, leukemogenesis,

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1. Mohty M. Indications for HSCT in adults: acute myeloid leukaemia. In: Appertley J, Carreras E, Gluckan E, Masszi T, editors. The EBMT handbook – haematopoietic stem cell transplantation. 6. ed. Paris: ESH – European School of Haematology; 2012: 317-29.
2. Fey MF, Buske C. ESMO Guidelines Working Group. Acute myeloblastic leukaemias in adult patients: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013; 24: 38-43.
3. De Kouchkovsky I, Abdul-Hay M. Acute myeloid leukemia: a comprehensive review and 2016 update. Blood Cancer J 2016; 6: e441.
4. Merdin A, Dal MS, Çakar MK, et al. Analysis of pre-chemotherapy WBC, PLT, monocyte, hemoglobin and MPV levels in acute myeloid leukemia patients with WT1, FLT3 or NPM gene mutations . Medicine 2020; 99: 14(e19627).
5. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci 2012; 49: 137–49.
6. Weisbrod AB, Nilubol N, Weinstein LS, et al. Association of type-O blood with neuroendocrine tumors in multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 2013; 98: 109–14.
7. Aird I, Bentall HH, Roberts JF. Relationship between cancer of stomach and the ABO bloodgroups. Br Med J. 1953; 1: 799.
8. Huang JY, Wang R, Gao YT, Yuan JM. ABO blood type and the risk of cancer – findings from the Shanghai Cohort study. PLoS One 2017; 12: e0184295.
9. Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB. ABO blood group and cancer. Eur J Cancer 2010; 46: 3345-50.
10. Novaretti M, Domingues A, Manhani R, Pinto E, Dorlhiac-Llacer P, Chamone D. ABO genotyping in leukemia patients reveals new ABO variant alleles. Genet Mol Res 2008; 7: 87-94.
11. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nature genetics. 2009; 41: 986- 90.
12. Nagy P, Jako J, Kiss A, Tamas E, Telek B, Rak K. Sex‐lınked dıfference ın blood‐group dıstrıbutıon among patients suffering from acute leukaemias. British journal of haematology. 1981; 48: 507-12.
13. Mustacchi P, Shonfeld EM, Lucia S. Survival in acute leukemia: the influence of blood groups, sex, and age at onset Ann Intern Med 1960; 52: 1099-107.
14. Sadeghian MH, Ebrahimzadeh S. Frequency of ABO and Rh blood groups in patients with acute leukemia. J Gorgan Uni Med Sci 2011; 13: 121-6.
15. Alavi S, Ashraf H, Rashidi A, Hosseini N, Abouzari M, Naderifar M. Distribution of ABO blood groups in childhood acute leukemia. Pediatr Hematol Oncol 2006; 23: 611–7.
16. Vadivelu MK, Damodaran S, Solomon J, Rajaseharan A. Distribution of ABO blood groups in acute leukaemias and lymphomas. Ann Hematol 2004; 83: 584–7.
17. Kar F, Andıç N,Kiraz Z, et al. Distribution of blood groups in different types of leukemia patients in Eskişehir, Turkey. Turkish J Life Sciences. 2018; 3: 214-7.