Diferansiye tiroid kanserlerinde nötrofil/lenfosit oranı ve monosit/yüksek dansiteli lipoprotein kolesterol oranının araştırılması

ÖZ Amaç: Tiroid kanserleri endokrin kökenli en yaygın malign tümörlerdir. Tiroid kanserleri histopatolojik ve klinik davranışlara göre sınıflandırılır. Papiller ve foliküler kanserler diferansiye tiroid kanserleri (DTK) olarak sınıflandırılırlar. Son zamanlarda nötrofil/lenfosit oranı (NLO) ve monosit/yüksek dansiteli lipoprotein kolesterol oranı (MHO) oksidatif stres ve sistemik inflamasyonun güçlü göstergeleri olduğu ve MHO’ nun koroner ateroskleroz ile ilişkili koroner kalp hastalığında mortalitenin güçlü göstergeleri olduğu ortaya konuldu. Bu çalışmamızda DTK tanısı konulmuş olan hastalarımızda bu belirteçleri değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmamıza DTK tanısı yeni konulan 125 hasta ve tamamen sağlıklı kişilerden oluşan 75 kişi kontrol grubu olarak dahil edildi. Hasta ve kontrol grubunun 12 saatlik açlık sonrası kolesterol parametreleri ve hematolojik parametreleri çalışılarak değerlendirmeye alındı. NLO ve MHO değerleri SPSS kullanılarak manuel olarak hesaplandı. Bulgular: Hasta ve sağlıklı grubun sırası ile NLO ortalaması (3,2±2,8 ve 2,4±1,3 p=0,013) ve MHO (0,038±0,052 ve 0,102±0,079 p=0,0000) şeklinde tespit edildi ve aralarında istatistiki açıdan anlamlı bir fark olduğu tespit edildi. Yapılan korelasyon analizinde ise NLO ile sırası ile beyaz küre (r=0,530, p<0,001), nötrofil ( r=0,293, p<0,001) ve CRP (r=0,371, p=0,005) arasında pozitif korelasyon tespit edilirken NLO ile lenfosit arasında (r=-0,271, p=0,001) negatif korelasyon tespit edildi. Sonuç: Bu çalışma ile elde edilen verilere göre diferansiye tiroid kanserlerinin sistemik inflamasyonu artırdığı gözlenmektedir.

Investigation of the neutrophil/lymphocyte and monocyte to high-density lipoprotein cholesterol ratios in differentiated thyroid cancers

ABSTRACT Introduction: Thyroid cancers are the most common malignant tumors of endocrine origin. They are classified depending on their histopathological and clinical behaviors. Papillary and follicular cancers are classified as differentiated thyroid carcinomas (DTCs). The neutrophil/lymphocyte ratio (NLR) and the monocyte to high-density lipoprotein cholesterol ratio (MHR) have recently been shown to be powerful markers of oxidative stress and systemic inflammation, and the MHR has been revealed as a potent marker of mortality in coronary heart disease associated with coronary atherosclerosis. The aim of this study was to evaluate these markers in patients diagnosed with DTC. Material and Method: One hundred twenty-five patients newly diagnosed with DTC and a 75-member control group consisting of entirely healthy individuals were included in the study. The patient and control groups were evaluated by investigation of cholesterol and hematological parameters following 12-h fasting. MHR and NLR values were calculated manually on SPSS software. Results: Significant differences were determined between the patient and control groups in terms of mean NLR (3.2±2.8 vs 2.4±1.3, respectively, p=0.013) and MHR (0.038±0.052 vs 0.102±0.079, respectively, p=0.0000) values. In the correlation analysis, positive correlation was determined between the NLR and white cell count (r=0.530, p<0.001), neutrophil count (r=0.293, p<0.001) and CRP (r=0.371, p=0.005), while negative correlation was determined between the NLR and lymphocyte count (r=-0.271, p=0.001). Conclusion: The study data show that DTCs increase systemic inflammation.

Keywords:

Differentiated thyroid carcinoma, neutrophil/lymphocyte ratio, monocyte to high-density lipoprotein cholesterol ratio,

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