Levels of serum copeptin in preeclampsia and association with maternal echocardiographic and doppler ultrasound parameters

Copeptin is a peptide, which has been reported as a valuable tool in the monitoring of major cardiovascular diseases such as myocardial infarction and heart failure. Echographic examinations are useful in assessment of alterations in cardiovascular structure and function during pregnancy. Having in mind the role of copeptin in the cardiovascular abnormalities and the subtle changes in heart and spiral arteries which can be detected by echography, the aim of the present study was to evaluate copeptin concentrations in preeclampsia (PE) and to investigate the existence of association between copeptin and maternal echocardiographic and Doppler ultrasound parameters. The current research was a case-control study. Fifty-five women with PE were examined. The mean age of patients was 24.9±6 years; and the mean age of the control group of 35 women with normal pregnancies was 24.7±5.4 years. The enzyme-linked immunosorbent assay (ELISA) was used to determine concentrations of copeptin. Echocardiographic assessment of all subjects was performed. In addition, uterine (UtA) artery pulsatility indices (PI) were evaluated. Levels of serum copeptin in preeclamptic women were statistically insignificantly lower than these in women with normal pregnancy: 142.2 (131.4÷146.7) vs. 144.8 (138.5÷ 149.4) ng/l (p>0.05). Copeptin correlated with systolic blood pressure (r=-0.41; p=0.0001), diastolic blood pressure (r=-0.30; p=0.004), UtA PI (r=-0.36; p=0.0005), IVS (r=-0.23; p=0.03) and LVPWD (r=-0.21; p=0.05). We report the existence of a relationship between serum copeptin and maternal echocardiographic and Doppler ultrasound parameters in preeclampsia. The present study give arguments for a potential copeptin implication on maternal cardiac structures and spiral arteries. Our results also confirm that copeptin is associated with increase of blood pressure in preeclampsia.

Keywords:

copeptin, blood pressure, echography preeclampsia, serum levels,

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