Effects of calcium channel blocker verapamil on spinal reflexes were studied. Verapamil 5, 50, (iM locally. 10,20 mg/kg was administradet intraperitoneally and 10, 50, 100 (iM localyy. Experiments on adult spinal cats (n=10) were conducted. Animals weighing 1,5-3 kg were anesthetized with ketamine (45 mg/kg intramuscular) and artiflcally ventilated. Animals were spinalized at Cj level and a laminectomy was performed in the lumbosacral region. The ventral and dorsal roots of segment Lg were isolated. A polyethylene cannule was int¬roduced into the carotid artery to monitor blood pressure, which was kept above 100 mmHg. The dorsal root of segment L5 placed on a silver-silver chloride wire electrod for electrical stimulation. The reflex potentials were recorded from the ipsilateral L5 ventral root, mounted on a silver-silver chloride wire electrode. Both systemic and local applica¬tion of verapamil inhibited reflexes (p