Abstract: Background: Coronavirus Disease-2019 (Covid-19) is the cause of a pandemic that has high mortality and global effects. The liver damage in Covid-19 cases in mechanical ventilation was investigated in this study. Materials and Methods: A total of 60 patients (the Study Group) who were diagnosed with Covid-19 pneumonia, and 65 individuals (the Control Group) were included prospectively in the study. The cases were divided into 3 groups as those who were intubated (severe), those who were not intubated (mild), and the healthy Control Group. The lung tomography results of those who were diagnosed with Covid-19 were examined in the study. The cases with positive RT-PCR (Real Time Polymerized Chain Reaction) test results were recorded from the system. The liver tests of the patients were compared with those of the Control Group. The two groups with and without intubation were also compared. The results were evaluated and analyzed statistically. Results: When all the data were evaluated, it was found that LDH, GGT, AST, and aPTT levels were significantly higher in the mild and severe patient group compared to the Control Group, and the T. Protein and albumin levels were low (p0.05). Conclusions: Increased D-dimer, GGT, D. Bil, LDH, NLR, and AST levels in Covid-19 patients in invasive mechanical ventilation are associated with mortality.