Verapamil Zehirlenmesi, İntravenöz Lipid Tedavisinin Önemi: Olgu Sunumu

İntravenöz lipid emülsiyon (İLE) tedavisi son yıllarda başta lokal anestezik ilaç toksisistesi olmak üzere lipofilik olan ilaç zehirlenmelerinde etkin bir antidot olarak kullanılmaktadır. Aşırı doz verapamil alımı, multi organ yetmezliğine yol açabilecek ve kanıtlanmış antidot tedavisi olmayan, ölümcül olabilen zehirlenmelere yol açabilir. Kalsiyum kanal blokörlerine (KKB) bağlı zehirlenmelerin tedavisinde dekontaminasyon, sıvı replasmanı, vasopressör ajanlar, glukagon yer almaktadır. Biz agresif tedaviye rağmen hipotansiyonları devam eden intravenöz lipid desteği sonucu başarı ile resüsite ettiğimiz hastamızı sunuyoruz.

Anahtar Kelimeler:

Verapamil, intravenöz lipid tedavisi, zehirlenme

Verapamil Poisoning, the Importance of Intravenous Lipid Therapy: Case Report

In recent years, intravenous lipid emulsions (ILE) have been used as an effective antidote to lipophilic drug poisonings, especially to local anaesthetic drug intoxication. Massive intentional verapamil overdose is a toxic ingestion that can cause multiorgan failure and currently has no known antidote, which can lead to fatal poisoning. Treatments for calcium channel blocker (CCB) intoxications include decontamination, fluid replacement, vasopressors and glucagon. Here, we present a patient who showed continued hypotension despite aggressive treatment but was successfully resuscitated following intravenous lipid support

Keywords:

Verapamil, intra-venous lipid therapy, intoxication,

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