Diagnosis of Transient Brain Lesion in the Corpus Callosum Splenium in Emergency Service and Elucidation of Accompanying Conditions

Corpus Callosum Cytotoxic Lesion (CLOCCs) once rarely seen in the literature has been more often diagnosed in emergency services nowadays with widespread use of cranial magnetic resonance imaging (MRI). CLOCCs is defined as a clinical and radiological spectrum disorder. Patient’s neurological symptoms usually improve completely within 1 month after the onset of the disease without any sequel. This is generally associated with cytotoxic edema of the splenium corpus callosum. It is important investigate the primary causes that lead to this condition and start the appropriate treatment according to the real diagnosis. We present a case diagnosed as CLOCCs secondary to pneumonia upon admission to our emergency service.

Keywords:

Corpus Callosum Splenium, Transient Brain Lesion,

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REFERENCES 1. Knyazeva MG. Splenium of corpus callosum: patterns of interhemispheric interaction in children and adults. Neural Plasticity. 2013, Article 639430. https://doi.org/10.1155/2013/639430
2. Bloom JS, Hynd GW. The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition? Neuropsychology Review. 2005;15:59-71.
3. Tada H, Takanashi J, Barkovich AJ, Oba H, Maeda M, Tsukahara H, et al. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology. 2004;63: 1854-8.
4. Galnares-Olalde, JA, Vázquez-Mézquita AJ, Gómez-Garza G, Reyes-Vázquez D, Higuera-Ortiz V, Alegría-Loyola MA, et al. Cytotoxic lesions of the corpus callosum caused by thermogenic dietary supplements. American Journal of Neuroradiology. 2019;40:1304-8.
5. Tetsuka S. Reversible lesion in the splenium of the corpus callosum. Brain And Behavior. 2019;9:e01440.
6. Starkey J, Kobayashi N, Numaguchi Y, Moritani T. Cytotoxic lesions of the corpus callosum that show restricted diffusion: mechanisms, causes, and manifestations. Radiographics. 2017;37:562-76.
7. EREN F, ÖNGÜN G, ÖZTÜRK Ş. Clinical and Radiological Significance of Transient Brain Lesion in the Corpus Callosum Splenium: 2 Case Reports. Kafkas Journal of Medical Sciences. 2018;8:133-6.
8. Xing C, Li W, Deng W, Ning M, Lo EH. A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes. Journal of Neuroinflammation. 2018;15:1-11.
9. Zhou Y, Danbolt NC. Glutamate as a neurotransmitter in the healthy brain. Journal of Neural Transmission. 2014;121:799-817.
10. ŞIMŞEK YURT N, ÇUBUKÇU M, YURT YC. Transient Brain Lesion in the Corpus Callosum Splenium: A Case Report. Ankara Medical Journal. 2020;20:749-54.