Yeliz BİLİR, Türker TAŞLIYURT, Faruk KUTLUTÜRK, Şafak ŞAHİN, Banu ÖZTÜRK, Göknur KALKAN, Süheyla UZUN KAYA, Abdulkerim YILMAZ

Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis

Aim: Recently, it has been proposed that chronic inflammation in psoriasis lead to metabolic syndrome (MetS) development. There is limited data about the relationship between psoriasis and IR. Aim of the present study was to investigate the prevalence of IR and MetS in psoriasis patients and the association between the severities of illnesses.Material and Method: The study consisted of 48 psoriasis patients and 45 healthy individuals. IR was estimated using homeostasis model assessment (HOMA) of IR formula. The psoriasis activity was evaluated by the psoriasis area and severity index (PASI). Patients were divided into 3 groups according to PASI scores.Results: MetS was observed in 21 patients (43.75%) and 8 controls (17.77%) (p=0.007). IR was observed in 16 patients (33.33%) and 5 controls (11.11%) (p=0.01). The frequencies of MetS and IR increased in psoriasis patients compared to healthy controls. According to linear regression analysis, PASI was independent risk factor for IR development (p=0.003).Conclusion: The incidences of MetS and IR were found to be higher in patients with psoriasis compared to control group. Especially there was a strong association between severe psoriasis and IR risk. Therefore, psoriasis needs to be considered as not only a skin disorder, but also a metabolic and cardiovascular disease.

Anahtar Kelimeler:

metabolik sendrom, psoriasis, insülin direnci, inflamasyon

Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis

Keywords:

metabolic syndrome, psoriasis, insulin resistance, inflammation,

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