Papiller renal hücreli karsinomun berrak hücreli renal hücreli karsinomlardan ayrımında yeni proteinler; DARS2, Reelin ve Enkurin'in Önemi

Amaç: Bu çalışma ile berrak hücreli böbrek hücreli karsinomlardan (BHK), papiller böbrek hücreli karsinom (BHK)’un ayırmında yeni proteinler olan DARS2, reelin ve enkurinin rollerinin incelenmesi amaçlandı. Berrak hücreli BHK, böbreğin en yaygın, papiller BHK ise ikinci sıklıkta görülen malign neoplazmları olup bazı durumlarda histolojik ve morfolojik olarak birbirleri ile benzerlik göstermektedir. Tedavi yaklaşımları ve prognozları farklı olduğu için ayırıcı tanıları önemlidir. Dikkatli histopatolojik inceleme ve spesifik immünohistokimyasal belirteçler tanı için önemli olmasına rağmen güvenilir bir şekilde kullanılabilecek spesifik antikorlar yoktur ve biyobelirteç arayışları devam etmektedir. Gereç ve Yöntem: Bu çalışmaya 30 adet berrak hücreli BHK ve 30 adet de papiller BHK olgusu dahil edildi. Hastalar, patolojik bir veri tabanının gözden geçirilmesiyle geriye dönük olarak tanımlandı. Patolojik veriler hastane tıbbi arşivlerinden ve patoloji raporlarından elde edildi. Bulgular: DARS2, reelin ve enkurin proteinleri papiller BHK da berrak hücreli BHK ya kıyasla anlamlı derecede yüksek bulundu. Sonuç: DARS2, reelin ve enkurin proteinlerinin papiller BHK ve berrak hücreli BHK ayrımı için potansiyel birer biyobelirleyiciler olabileceği sonucuna varılmıştır.

Anahtar Kelimeler:

DARS, Reelin, Enkurin, Papiller böbrek hücreli karsinom, Berrak hücreli böbrek hücreli karsinom, biyobelirteç, immunohistokimya

New proteins in the differentiation of papillary renal cell carcinoma from clear cell renal cell carcinomas; Importance of DARS2, Reelin and Enkurin

Purpose: The purpose of the present study was to examine the roles of new proteins DARS2, Reelin, and Encurin in the differentiation of Clear-Cell Renal Cell Carcinoma (RCC) and Papillary Renal Cell Carcinoma (RCC). Clear-cell RCC is the most common malignancy of the kidney, and papillary RCC is the second most common malignant malignancy in this respect. They are neoplasms and show similarity to each other, both histologically and morphologically, in some cases. Differential diagnosis is important because treatment approaches and prognoses are different. Although careful histopathological examination and specific immunohistochemical markers are important for diagnosis, there are no specific antibodies that can be used reliably and the search for biomarkers continues in this regard. Materials and Methods: A total of 30 Clear-Cell RCC and 30 Papillary RCC cases were included in the present study. Patients were identified retrospectively by reviewing the hospital database and pathological reports. Pathological data were obtained from hospital medical archives and pathology reports. Results: It was found that DARS2, Reelin, and Encurin proteins were significantly higher in papillary RCC when compared to clear-cell RCC. Conclusion: It was concluded that DARS2, Reelin, and Encurin proteins may be potential biomarkers for the differentiation of Papillary RCC and Clear-Cell RCC.

Keywords:

DARS, Reelin, Encurin, Papillary Renal Cell Carcinoma, Clear-cell Renal Cell Carcinoma, biomarker, immunohistochemistry,

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